{"id":"https://openalex.org/W2374822997","doi":null,"title":"Influence of raloxifene on expression of TNF-\u03b1 in cancellous bone and bone mineral density in ovariectomized rats","display_name":"Influence of raloxifene on expression of TNF-\u03b1 in cancellous bone and bone mineral density in ovariectomized rats","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2374822997","mag":"2374822997"},"language":"en","primary_location":{"id":"mag:2374822997","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-DSJY200710010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764924667","display_name":"Di-Si Junyi Daxue xuebao","issn_l":"1000-2790","issn":["1000-2790"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322632808","host_organization_name":"Fourth Military University","host_organization_lineage":["https://openalex.org/P4322632808"],"host_organization_lineage_names":["Fourth Military University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-Si Junyi Daxue xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yong Duan","orcid":"https://orcid.org/0000-0003-3410-0504","observed_orcids":["https://orcid.org/0000-0003-3410-0504"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yong Duan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3410-0504","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39787549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.3407999873161316,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0658000037074089,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":1.0},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8809999823570251},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.984000027179718},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.953000009059906},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.906000018119812},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.9766823053359985},{"id":"https://openalex.org/C2776350087","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cancellous bone","level":2,"score":0.8393409252166748},{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.7609548568725586},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7500123977661133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7352168560028076},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.7071282863616943},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6339099407196045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5444452166557312},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4476378560066223},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.2738252282142639},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20651811361312866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2374822997","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-DSJY200710010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764924667","display_name":"Di-Si Junyi Daxue xuebao","issn_l":"1000-2790","issn":["1000-2790"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322632808","host_organization_name":"Fourth Military University","host_organization_lineage":["https://openalex.org/P4322632808"],"host_organization_lineage_names":["Fourth Military University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-Si Junyi Daxue xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2375000263","https://openalex.org/W2364035367","https://openalex.org/W3017907638","https://openalex.org/W2376601668","https://openalex.org/W2048753003","https://openalex.org/W2372745384","https://openalex.org/W2370443829","https://openalex.org/W2384409582","https://openalex.org/W2098094434","https://openalex.org/W1017845997"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"discuss":[2],"the":[3,12,112,156,195,211,218,228,240],"influence":[4],"of":[5,14,88,114,120,128,158,181,189,209,220,230,235,242],"selective":[6],"estrogen":[7],"receptor":[8],"modulator(SERM)":[9],"raloxifene(RAL)":[10],"on":[11,55,66],"expression":[13,113,157,229],"TNF-\u03b1":[15,115,129,159,231],"in":[16,25,116,130,133,140,149,160,163,232,244],"cancellous":[17,131,161,233],"bone":[18,20,119,132,162,197,234],"and":[19,47,58,105,144,169,194,200,238],"mineral":[21],"density":[22],"(BMD)":[23],"loss":[24],"ovariectomized":[26,45,190,236,245],"rats.":[27,246],"METHODS:":[28],"Thirty":[29],"8-month":[30],"nulliparous":[31],"female":[32],"SD":[33],"rats":[34,40,85,191,237],"were":[35,53,86,96,108,214],"divided":[36],"into":[37],"3":[38],"groups(10":[39],"per":[41],"group):sham":[42],"operation":[43,63],"(SHAM)group,":[44],"(OVX)group":[46],"therapeutic":[48],"(OVX+":[49],"RAL)group.":[50],"Bilateral":[51],"ovariectomies":[52],"done":[54],"OVX":[56,134,164],"group":[57,71,135,142,152,165,222],"OVX+":[59,69,150],"RAL":[60,70,75,151,173,225],"group.":[61,68,122],"Sham":[62],"was":[64,72,136],"performed":[65],"SHAM":[67,141,205,221],"treated":[73],"with":[74,204],"2":[76],"d":[77],"after":[78,82,167,172,178],"operation.":[79],"Twenty":[80,176],"weeks":[81,177],"operation,":[83],"all":[84],"sacrificed.BMD":[87],"L3-L5":[89,182],"vertebrae,":[90,183],"proximal":[91,184],"femoral":[92,94,185,187],"segment,":[93,186],"body":[95,188],"measured":[97],"by":[98],"dual":[99],"energy":[100],"X-ray":[101],"absorptiometry(DEXA).":[102],"SABC":[103],"immunohistochemistry":[104],"image":[106],"analysis":[107],"used":[109],"to":[110,217],"detect":[111],"L2":[117],"vertebral":[118],"every":[121],"RESULTS:":[123],"\u2460":[124],"The":[125],"gray":[126],"scale":[127],"lower":[137,146],"than":[138,147],"that":[139,148,155],"(P0.01),":[143,153],"also":[145],"indicating":[154],"increased":[166],"ovariectomy,":[168,179],"became":[170,198],"weak":[171],"treatment.":[174],"\u2461":[175],"BMD":[180],"decreased":[192],"significantly":[193],"trabecular":[196],"thinner":[199],"irregular":[201],"as":[202],"compared":[203],"group(P0.01).":[206],"After":[207],"treatment":[208],"RAL,":[210],"above":[212],"parameters":[213],"maintained":[215],"close":[216],"level":[219],"(P0.05).":[223],"CONCLUSION:":[224],"could":[226],"inhibit":[227],"depress":[239],"occurrence":[241],"osteoporosis":[243]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}