{"id":"https://openalex.org/W2374724670","doi":"https://doi.org/10.1111/jam.13154","title":"Functional characterization of a novel \u03b2-fructofuranosidase from Bifidobacterium longum subsp. infantis ATCC 15697 on structurally diverse fructans","display_name":"Functional characterization of a novel \u03b2-fructofuranosidase from Bifidobacterium longum subsp. infantis ATCC 15697 on structurally diverse fructans","publication_year":2016,"publication_date":"2016-04-18","ids":{"openalex":"https://openalex.org/W2374724670","doi":"https://doi.org/10.1111/jam.13154","mag":"2374724670","pmid":"https://pubmed.ncbi.nlm.nih.gov/27086652"},"language":"en","primary_location":{"id":"doi:10.1111/jam.13154","doi":"https://doi.org/10.1111/jam.13154","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jam.13154","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064156747","display_name":"\u00c1ngela \u00c1vila-Fern\u00e1ndez","orcid":"https://orcid.org/0000-0001-6432-4715","observed_orcids":["https://orcid.org/0000-0001-6432-4715"]},"institutions":[{"id":"https://openalex.org/I93173995","display_name":"Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco","ror":"https://ror.org/04ee58018","country_code":"MX","type":"education","lineage":["https://openalex.org/I93173995"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"\u00c1. \u00c1vila-Fern\u00e1ndez","raw_affiliation_strings":["Centro de Investigaci\u00f3n; DACS-Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco; Tabasco M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n; DACS-Universidad Ju\u00e1rez Aut\u00f3noma de Tabasco; Tabasco M\u00e9xico","institution_ids":["https://openalex.org/I93173995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076756225","display_name":"Esmeralda Cuevas\u2010Ju\u00e1rez","orcid":"https://orcid.org/0000-0003-4200-685X","observed_orcids":["https://orcid.org/0000-0003-4200-685X"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"E. Cuevas-Ju\u00e1rez","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062747560","display_name":"Maria Elena Rodr\u00edguez-Alegr\u00eda","orcid":"https://orcid.org/0000-0001-6789-705X","observed_orcids":["https://orcid.org/0000-0001-6789-705X"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M.E. Rodr\u00edguez-Alegr\u00eda","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060002378","display_name":"Clarita Olvera","orcid":"https://orcid.org/0000-0002-8364-5845","observed_orcids":["https://orcid.org/0000-0002-8364-5845"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"C. Olvera","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026832226","display_name":"Agust\u00edn L\u00f3pez-Mungu\u00eda","orcid":"https://orcid.org/0000-0003-4204-4936","observed_orcids":["https://orcid.org/0000-0003-4204-4936"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"A. L\u00f3pez-Mungu\u00eda","raw_affiliation_strings":["Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda; Universidad Nacional Aut\u00f3noma de M\u00e9xico; Cuernavaca Morelos M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026832226"],"corresponding_institution_ids":["https://openalex.org/I8961855"],"apc_list":{"value":2864,"currency":"GBP","value_usd":3777},"apc_paid":null,"fwci":2.1441,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.84526171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"121","issue":"1","first_page":"263","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.03319999948143959,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invertase","display_name":"invertase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bifidobacterium-longum-subsp-infantis","display_name":"Bifidobacterium longum subsp. infantis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fructan-hydrolysis","display_name":"fructan hydrolysis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/inulin","display_name":"inulin","score":0.7120000123977661},{"id":"https://openalex.org/keywords/agave-fructans","display_name":"agave fructans","score":0.8700000047683716},{"id":"https://openalex.org/keywords/enzyme-substrate-specificity","display_name":"enzyme substrate specificity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/enzyme-thermostability","display_name":"enzyme thermostability","score":0.7570000290870667},{"id":"https://openalex.org/keywords/recombinant-enzyme-production","display_name":"recombinant enzyme expression","score":0.8149999976158142},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5210000276565552},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2776996202","wikidata":"https://www.wikidata.org/wiki/Q4904768","display_name":"Bifidobacterium longum","level":5,"score":0.952651858329773},{"id":"https://openalex.org/C2779742124","wikidata":"https://www.wikidata.org/wiki/Q201552","display_name":"Inulin","level":2,"score":0.9279828071594238},{"id":"https://openalex.org/C73583747","wikidata":"https://www.wikidata.org/wiki/Q421961","display_name":"Fructan","level":3,"score":0.9183493256568909},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4766272306442261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4745098948478699},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.47352170944213867},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4471292793750763},{"id":"https://openalex.org/C2779001512","wikidata":"https://www.wikidata.org/wiki/Q877696","display_name":"Actinomycetaceae","level":5,"score":0.44120272994041443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42199188470840454},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.39281532168388367},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.3857460916042328},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.33573079109191895},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.1925887167453766}],"mesh":[{"descriptor_ui":"D000070236","descriptor_name":"Bifidobacterium longum subspecies infantis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000070236","descriptor_name":"Bifidobacterium longum subspecies infantis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000070236","descriptor_name":"Bifidobacterium longum subspecies infantis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005630","descriptor_name":"Fructans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005630","descriptor_name":"Fructans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043324","descriptor_name":"beta-Fructofuranosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043324","descriptor_name":"beta-Fructofuranosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043324","descriptor_name":"beta-Fructofuranosidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jam.13154","doi":"https://doi.org/10.1111/jam.13154","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jam.13154","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},{"id":"pmid:27086652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27086652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1875934521","https://openalex.org/W1983742464","https://openalex.org/W1999605325","https://openalex.org/W2000804003","https://openalex.org/W2009145554","https://openalex.org/W2009674410","https://openalex.org/W2013107815","https://openalex.org/W2018965759","https://openalex.org/W2036585959","https://openalex.org/W2045065731","https://openalex.org/W2048550695","https://openalex.org/W2052969143","https://openalex.org/W2060074044","https://openalex.org/W2063563625","https://openalex.org/W2067314615","https://openalex.org/W2067871824","https://openalex.org/W2068330668","https://openalex.org/W2072397581","https://openalex.org/W2073486553","https://openalex.org/W2083658593","https://openalex.org/W2086230737","https://openalex.org/W2098278200","https://openalex.org/W2110205241","https://openalex.org/W2111337712","https://openalex.org/W2117065897","https://openalex.org/W2122678166","https://openalex.org/W2133884639","https://openalex.org/W2141313834","https://openalex.org/W2150326634","https://openalex.org/W2157274363","https://openalex.org/W2158447557","https://openalex.org/W2160255949","https://openalex.org/W2166522721","https://openalex.org/W2167489922","https://openalex.org/W2168595823","https://openalex.org/W2271437264","https://openalex.org/W2316109761","https://openalex.org/W2511265541"],"related_works":["https://openalex.org/W2083658593","https://openalex.org/W2045065731","https://openalex.org/W2060074044","https://openalex.org/W2003030077","https://openalex.org/W2160255949","https://openalex.org/W2316109761","https://openalex.org/W2621225372","https://openalex.org/W7100288536","https://openalex.org/W2073486553","https://openalex.org/W2015190581"],"abstract_inverted_index":{"AIM:":[0],"In":[1],"this":[2,33,223],"study,":[3],"we":[4],"describe":[5],"the":[6,23,26,28,41,149,164,202,218,226,270],"isolation":[7],"of":[8,25,68,85,163,187,194,222,244,272],"a":[9,12,65,79,83,92,184,209,241],"gene":[10],"encoding":[11],"novel":[13],"\u03b2-fructofuranosidase":[14,236],"from":[15],"Bifidobacterium":[16],"longum":[17],"subsp.":[18],"infantis":[19],"ATCC":[20],"15697,":[21],"and":[22,78,129,141,153,169,177,189,220,252,267],"characterization":[24],"enzyme,":[27,213],"second":[29],"one":[30],"found":[31,51,156,173],"in":[32,37,56,225],"strain,":[34],"significantly":[35],"different":[36],"primary":[38],"sequence":[39],"to":[40,174,217,269],"already":[42],"reported":[43],"bifidobacterial":[44,235],"\u03b2-fructofuranosidases.":[45],"METHODS":[46],"AND":[47,229],"RESULTS:":[48],"The":[49,60,160,234],"gene,":[50],"through":[52,100],"genome-mining":[53],"was":[54,172,238],"expressed":[55],"Escherichia":[57],"coli":[58],"C41(DE3).":[59],"recombinant":[61],"enzyme":[62,165],"(B.longum_l1)":[63],"has":[64,91],"molecular":[66],"weight":[67],"75":[69],"kDa,":[70],"with":[71,82,148,183,240],"optimal":[72],"activity":[73,152,186,203,237,257],"at":[74,88],"50\u00b0C,":[75],"pH":[76],"6\u00b70-6\u00b75,":[77],"remarkable":[80],"stability":[81],"half-life":[84],"75\u00b75":[86],"h":[87],"50\u00b0C.":[89],"B.longum_l1":[90,207],"wide":[93,210,242],"specificity":[94,212],"for":[95,157,166,204],"fructans,":[96,138,248],"hydrolysing":[97],"all":[98],"substrates":[99,245,260],"an":[101],"exo-type":[102],"mechanism,":[103],"including":[104,246],"Oligofructose":[105,170],"P95":[106,171],"(\u03b22-1":[107],"fructooligosaccharides":[108],"(FOS),":[109],"DP":[110,118,123,139,146],"2-8),":[111,147],"Raftilose":[112],"Synergy":[113],"1(\u03b22-1":[114],"FOS":[115,143,168],"&":[116,132],"inulin,":[117],"2-60),":[119,124],"Raftiline":[120],"HP":[121],"(inulin,":[122],"bacterial":[125],"inulin":[126],"(3000":[127],"kDa)":[128],"levan":[130],"(8\u00b73":[131],"3500":[133],"kDa),":[134],"Agave":[135],"fructans":[136],"(mixed":[137],"3-29)":[140],"levan-type":[142,158,167,251],"(\u03b22-6":[144],"FOS,":[145],"highest":[150],"relative":[151],"turnover":[154],"number":[155],"FOS.":[159],"apparent":[161],"affinity":[162],"be":[175],"9\u00b72":[176],"4\u00b76":[178],"mmol":[179],"l(-1)":[180],"(Km":[181],")":[182],"specific":[185],"908":[188],"725":[190],"\u03bcmol":[191],"min(-1)":[192],"mg(-1)":[193],"protein":[195],"(k2":[196],"),":[197],"respectively,":[198],"more":[199],"than":[200],"twice":[201],"sucrose.":[205],"CONCLUSION:":[206],"is":[208],"substrate":[211],"which":[214],"may":[215],"contribute":[216],"competitiveness":[219],"persistence":[221],"strain":[224],"colon.":[227],"SIGNIFICANCE":[228],"IMPACT":[230],"OF":[231],"THE":[232],"STUDY:":[233],"evaluated":[239],"variety":[243],"noncommercial":[247],"such":[249],"as":[250],"mixed":[253],"agave":[254],"fructans.":[255,278],"Its":[256],"on":[258],"these":[259],"certainly":[261],"strengthens":[262],"their":[263],"commercial":[264],"prebiotic":[265],"character":[266],"contributes":[268],"understanding":[271],"bifidobacteria":[273],"stimulation":[274],"by":[275],"structurally":[276],"diverse":[277]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}