{"id":"https://openalex.org/W237465452","doi":null,"title":"Evaluation of neuroprotective effects of natural extracts obtained from portuguese agro-food residues","display_name":"Evaluation of neuroprotective effects of natural extracts obtained from portuguese agro-food residues","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W237465452","mag":"237465452"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/14856","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14856","pdf_url":"https://run.unl.pt/bitstreams/31addc78-8a4b-4f1e-9bc6-58113340fc2e/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://run.unl.pt/bitstreams/31addc78-8a4b-4f1e-9bc6-58113340fc2e/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046784845","display_name":"Rita Jo\u00e3o Rosado Serranito Ramos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rita Jo\u00e3o Rosado Serranito Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046784845"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.3959999978542328,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12330","display_name":"Botanical Research and Applications","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9670000076293945},{"id":"https://openalex.org/keywords/fruit-by-products","display_name":"fruit by-products","score":0.8230000138282776},{"id":"https://openalex.org/keywords/opuntia-ficus-indica","display_name":"Opuntia ficus-indica","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sweet-cherry","display_name":"sweet cherry","score":0.9919999837875366},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8840000033378601},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/hydrogen-peroxide-induced-cell-death","display_name":"hydrogen peroxide-induced cell death","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.75},{"id":"https://openalex.org/keywords/pressurized-liquid-extraction","display_name":"accelerated solvent extraction","score":0.8849999904632568},{"id":"https://openalex.org/keywords/solvent-extraction","display_name":"solvent extraction","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.737837553024292},{"id":"https://openalex.org/C2993572104","wikidata":"https://www.wikidata.org/wiki/Q6980681","display_name":"Natural food","level":2,"score":0.6374946236610413},{"id":"https://openalex.org/C35219183","wikidata":"https://www.wikidata.org/wiki/Q5146","display_name":"Portuguese","level":2,"score":0.599456250667572},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38639551401138306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3395116925239563},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3191419243812561},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29780489206314087},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.23313093185424805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20009097456932068},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.11396706104278564},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.060588687658309937}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/14856","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14856","pdf_url":"https://run.unl.pt/bitstreams/31addc78-8a4b-4f1e-9bc6-58113340fc2e/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:237465452","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/14856/1/Ramos_2012.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/14856","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/14856","pdf_url":"https://run.unl.pt/bitstreams/31addc78-8a4b-4f1e-9bc6-58113340fc2e/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W237465452.pdf","grobid_xml":"https://content.openalex.org/works/W237465452.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W1493373324","https://openalex.org/W1963838380","https://openalex.org/W1964209473","https://openalex.org/W1964210926","https://openalex.org/W1968212965","https://openalex.org/W1969570348","https://openalex.org/W1973058491","https://openalex.org/W1973455163","https://openalex.org/W1974407542","https://openalex.org/W1975643870","https://openalex.org/W1977371315","https://openalex.org/W1977955039","https://openalex.org/W1980974610","https://openalex.org/W1984632761","https://openalex.org/W1985091566","https://openalex.org/W1986524172","https://openalex.org/W1986951130","https://openalex.org/W1989526706","https://openalex.org/W1996129544","https://openalex.org/W1996170441","https://openalex.org/W1999582366","https://openalex.org/W2001785324","https://openalex.org/W2005952102","https://openalex.org/W2007994035","https://openalex.org/W2015235246","https://openalex.org/W2021301578","https://openalex.org/W2021460489","https://openalex.org/W2023212325","https://openalex.org/W2023536393","https://openalex.org/W2024412670","https://openalex.org/W2026304334","https://openalex.org/W2027063851","https://openalex.org/W2029117284","https://openalex.org/W2036471655","https://openalex.org/W2039730018","https://openalex.org/W2040278300","https://openalex.org/W2040569675","https://openalex.org/W2041300408","https://openalex.org/W2046067264","https://openalex.org/W2046499757","https://openalex.org/W2047273027","https://openalex.org/W2047472097","https://openalex.org/W2047626527","https://openalex.org/W2050866571","https://openalex.org/W2051421916","https://openalex.org/W2052411694","https://openalex.org/W2053058287","https://openalex.org/W2053877056","https://openalex.org/W2056978008","https://openalex.org/W2058016732","https://openalex.org/W2061455471","https://openalex.org/W2064926938","https://openalex.org/W2066421513","https://openalex.org/W2067773691","https://openalex.org/W2069575624","https://openalex.org/W2070895853","https://openalex.org/W2071765776","https://openalex.org/W2075041427","https://openalex.org/W2077344864","https://openalex.org/W2077752599","https://openalex.org/W2078962576","https://openalex.org/W2080084871","https://openalex.org/W2080164215","https://openalex.org/W2082271081","https://openalex.org/W2089363473","https://openalex.org/W2089977716","https://openalex.org/W2093979148","https://openalex.org/W2095142150","https://openalex.org/W2095404602","https://openalex.org/W2096997867","https://openalex.org/W2103338237","https://openalex.org/W2110857736","https://openalex.org/W2119260493","https://openalex.org/W2119331100","https://openalex.org/W2123122317","https://openalex.org/W2126075942","https://openalex.org/W2127676938","https://openalex.org/W2131655927","https://openalex.org/W2133465841","https://openalex.org/W2133919202","https://openalex.org/W2135225310","https://openalex.org/W2136579586","https://openalex.org/W2138189025","https://openalex.org/W2144781766","https://openalex.org/W2154105741","https://openalex.org/W2154131110","https://openalex.org/W2155953889","https://openalex.org/W2162518284","https://openalex.org/W2163726983","https://openalex.org/W2168024298","https://openalex.org/W2170667061","https://openalex.org/W2187683320","https://openalex.org/W2258078429","https://openalex.org/W2289097248","https://openalex.org/W2289494623","https://openalex.org/W2319826091"],"related_works":["https://openalex.org/W2557291634","https://openalex.org/W4318261323","https://openalex.org/W2373584551","https://openalex.org/W2015333763","https://openalex.org/W3041902025","https://openalex.org/W2108874795","https://openalex.org/W2514617609","https://openalex.org/W7220758760","https://openalex.org/W2913087820","https://openalex.org/W2315260042"],"abstract_inverted_index":{"Countries":[0],"are":[1,26,45,246,256],"currently":[2],"faced":[3],"with":[4,47,54,200,266,270],"problems":[5],"derived":[6],"from":[7,34,219,286],"changes":[8],"in":[9,14,30,77,90,114,132,169,208,259,263],"lifespan":[10],"and":[11,22,59,92,102,129,152,172,194,204,268],"an":[12,27],"increase":[13],"lifestyle-related":[15],"diseases.":[16,79],"Neurodegenerative":[17],"disorders":[18],"such":[19,100],"Parkinson\u2019s":[20],"(PD)":[21],"Alzheimer\u2019s":[23],"(AD)":[24],"diseases":[25,99],"increasing":[28],"problem":[29],"aged":[31],"societies.":[32],"Data":[33],"World":[35],"Alzheimer":[36],"Report":[37],"2011":[38],"indicate":[39],"that":[40],"36":[41],"million":[42],"people":[43],"worldwide":[44],"living":[46],"dementia.":[48],"Oxidative":[49],"stress":[50],"has":[51,164,235],"been":[52],"associated":[53],"the":[55,74,95,115,142,146,150,189],"development":[56],"of":[57,86,97,107,111,117,145,161,184,191,243],"AD":[58,101],"PD.":[60,103],"Therefore":[61],"there":[62,255],"is":[63,126,138],"interest":[64],"to":[65,72,94,149,166,173,179,228,277,280,291],"search":[66],"for":[67],"effective":[68],"compounds":[69,88,171],"or":[70],"therapies":[71],"combat":[73],"oxidative":[75],"damage":[76],"these":[78],"Current":[80],"evidence":[81],"strongly":[82],"supports":[83],"a":[84,108,209,236,250,281],"contribution":[85],"phenolic":[87,170],"present":[89],"fruits":[91,112,147,154],"vegetables":[93],"prevention":[96],"neurodegenerative":[98],"The":[104,182,240],"industrial":[105],"processing":[106],"wide":[109],"variety":[110],"results":[113],"accumulation":[116],"by-products":[118,197],"without":[119],"commercial":[120,157],"value.":[121,158],"Opuntia":[122,244],"ficus-indica":[123,193],"(cactus":[124],"pear)":[125],"consumed":[127,139],"fresh":[128,140],"processed":[130],"like":[131],"juice.":[133],"Prunnus":[134],"avium":[135,196],"(sweet":[136],"cherry)":[137],"but":[141],"organoleptics":[143],"characteristics":[144],"leads":[148],"smaller":[151],"ragged":[153],"have":[155,174,215],"no":[156],"Fruit":[159],"extracts":[160,198,214,245,267],"both":[162],"species":[163],"described":[165],"be":[167,278],"rich":[168],"high":[175],"antioxidant":[176,252],"activities":[177],"due":[178,279],"its":[180],"composition.":[181],"aim":[183],"this":[185],"work":[186],"was":[187],"assessing":[188],"efficacy":[190],"O.":[192],"P.":[195],"obtained":[199],"conventional":[201],"solvent":[202],"extraction":[203,207],"pressurized":[205],"liquid":[206],"neurodegeneration":[210],"cell":[211,264],"model.":[212],"All":[213],"protected":[216],"neuroblastoma":[217],"cells":[218,294],"H2O2-induced":[220],"death":[221],"at":[222],"low,":[223],"non-toxic":[224],"levels,":[225],"which":[226],"approach":[227],"physiologically-relevant":[229],"serum":[230],"concentration.":[231],"However,":[232],"cherry":[233,273],"extract":[234,274],"slighter":[237],"neuroprotective":[238],"activity.":[239,284],"protective":[241],"effect":[242],"not":[247,257],"conducted":[248],"by":[249],"direct":[251,282],"activity":[253],"since":[254],"decreases":[258],"intracellular":[260],"ROS":[261],"levels":[262],"treated":[265],"challenged":[269],"H2O2,":[271],"while":[272],"neuroprotection":[275],"seems":[276,290],"scavenging":[283],"Extracts":[285],"different":[287,296],"biological":[288],"matrixes":[289],"protect":[292],"neuronal":[293],"trough":[295],"cellular":[297],"mechanisms.":[298]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}