{"id":"https://openalex.org/W2374594512","doi":null,"title":"EFFECTS OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR ON THE EXPRESSION OF p-Akt IN SPINAL CORD IN A RAT MODEL OF NEUROPATHIC PAIN","display_name":"EFFECTS OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR ON THE EXPRESSION OF p-Akt IN SPINAL CORD IN A RAT MODEL OF NEUROPATHIC PAIN","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2374594512","mag":"2374594512"},"language":"en","primary_location":{"id":"mag:2374594512","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZTYZ201404007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765072277","display_name":"Zhongguo tengtong yixue zazhi","issn_l":"1006-9852","issn":["1006-9852"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo tengtong yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100736174","display_name":"Cun Wang","orcid":"https://orcid.org/0000-0001-6413-4786","observed_orcids":["https://orcid.org/0000-0001-6413-4786"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4405272752","display_name":"Jiangsu Province Key Laboratory of Anesthesiology","ror":"https://ror.org/04ns96806","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272752"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cun Wang","raw_affiliation_strings":["Key Laboratory of Anesthesiology in Jiangsu Province,Key Laboratory of Anesthesia and Analgesia Application Technology in Jiangsu Province,Xuzhou Medical College"],"raw_orcid":"https://orcid.org/0000-0001-6413-4786","affiliations":[{"raw_affiliation_string":"Key Laboratory of Anesthesiology in Jiangsu Province,Key Laboratory of Anesthesia and Analgesia Application Technology in Jiangsu Province,Xuzhou Medical College","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100736174"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4405272752"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29763573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/p-akt","display_name":"pAKT","score":0.7400000095367432},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9729999899864197},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.859000027179718},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.8410000205039978},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.8859999775886536},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.8982301950454712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8248341083526611},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.7850766181945801},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6984009742736816},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6267876625061035},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5713539123535156},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.4388737380504608},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4374850392341614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.412457138299942},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3861766457557678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2100631296634674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07212704420089722},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2374594512","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZTYZ201404007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765072277","display_name":"Zhongguo tengtong yixue zazhi","issn_l":"1006-9852","issn":["1006-9852"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo tengtong yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588240518","https://openalex.org/W2024948844","https://openalex.org/W2355945934","https://openalex.org/W2390291681","https://openalex.org/W3088937785","https://openalex.org/W2391827726","https://openalex.org/W3029032607","https://openalex.org/W2171291498","https://openalex.org/W2157024275","https://openalex.org/W2068682087"],"abstract_inverted_index":{"Objective:To":[0],"investigate":[1],"the":[2,7,19,24,87,93,130,135,139,145,149,236,241],"expression":[3,20,184],"of":[4,9,12,21,31,89,113,122,148,164,177,186,211,219,238,243,249,256],"p-Akt":[5,22,187,209,257],"and":[6,42,63,82,117,138,157,173,197,222],"effect":[8],"intrathecal":[10,247],"injection":[11],"glial":[13],"cell":[14],"line-derived":[15],"neurotrophic":[16],"factor(GDNF)":[17],"on":[18],"in":[23,27,188,229,235,259],"spinal":[25,94,150,230,260],"cord":[26,151,231],"a":[28,200,254],"rat":[29],"model":[30],"neuropathic":[32,239,244],"pain.Methods:Experiment":[33],"1:Male":[34],"Sprague-Dawley":[35,103],"rats":[36,104,140],"were":[37,91,105,141],"divided":[38,49,106],"into":[39,50,107],"control":[40,108,161],"group":[41,46,166,171,174,178,190,213,221],"CCI":[43,45,165,189],"group.The":[44],"was":[47,71,97,127,152,180],"further":[48],"1":[51,78,137],"d":[52,56,65,81,84,196],"postoperative":[53,57,60,66],"group(group":[54,58,61,67],"D1),3":[55],"D3),7d":[59],"D7)":[62],"14":[64,83,204],"D14).The":[68],"thermal":[69,74],"hyperalgesia":[70],"assessed":[72],"with":[73,111,120,160,170,253],"withdrawal":[75],"latency(TWL)":[76],"at":[77,129,143,194,199],"d,3":[79],"d,7":[80],"after":[85,206],"CCI.After":[86],"determination":[88],"TWL,rats":[90],"sacrificed,and":[92],"dorsal":[95,146],"horn":[96,147],"collected":[98,153],"for":[99,154],"Western":[100,155],"blot.Experiment":[101],"2:Male":[102],"group,groupD14',D14'":[109],"combined":[110,119],"treatment":[112,121],"PBS":[114],"group(D14'+PBS":[115],"group)":[116],"D14'":[118,172,220],"GDNF":[123,250],"group(D14'+GDNF":[124],"group).The":[125],"TWL":[126,163,176],"determined":[128],"same":[131],"time":[132],"point":[133],"as":[134],"experiment":[136],"sacrificed":[142],"14d,then":[144],"blot":[156],"immunohistochemistry":[158],"analysis.Results:Compared":[159],"group,the":[162],"decreased":[167,214],"significantly(P":[168],"0.01).Compared":[169],"D14'+PBS,the":[175],"D14'+GDNF":[179,212],"significantly":[181,215],"increased(P":[182],"0.01).The":[183],"level":[185,202,210,258],"began":[191],"to":[192,217],"increase":[193],"3":[195],"sustained":[198],"high":[201],"until":[203],"days":[205],"operation(P":[207],"0.01),the":[208],"compared":[216],"that":[218],"D14'+PBS":[223],"group(P":[224],"0.05).Conclusion:The":[225],"Akt":[226],"signaling":[227],"pathway":[228],"may":[232],"be":[233],"involved":[234],"mechanism":[237],"pain,and":[240],"alleviation":[242],"pain":[245],"by":[246],"administration":[248],"is":[251],"associated":[252],"decrease":[255],"cord.":[261]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
