{"id":"https://openalex.org/W2374479875","doi":null,"title":"Study on expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation","display_name":"Study on expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2374479875","mag":"2374479875"},"language":"en","primary_location":{"id":"mag:2374479875","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHXX200403004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764975887","display_name":"Zhonghua xinxueguanbing zazhi","issn_l":"0253-3758","issn":["0253-3758"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua xinxueguanbing zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103589581","display_name":"Wang Xiang","orcid":"https://orcid.org/0000-0001-9815-1277","observed_orcids":["https://orcid.org/0000-0001-9815-1277"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wang Xiang","raw_affiliation_strings":["*, DAI You  ping,YANG Miao, WU Tang  chun, CAO Lin  sheng, DAI Gui  zhu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*, DAI You  ping,YANG Miao, WU Tang  chun, CAO Lin  sheng, DAI Gui  zhu","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103589581"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33629018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.996999979019165},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase","display_name":"extracellular signal-regulated kinase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/extracellular-signal-regulated-kinase-1-2","display_name":"ERK1/ERK2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9629999995231628},{"id":"https://openalex.org/keywords/atrial-fibrosis","display_name":"atrial fibrosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/rheumatic-heart-disease","display_name":"rheumatic heart disease","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chronic-atrial-fibrillation","display_name":"chronic atrial fibrillation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/paroxysmal-atrial-fibrillation","display_name":"paroxysmal atrial fibrillation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8158589601516724},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.7164211273193359},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.697157084941864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6108989715576172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6072449684143066},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5787160396575928},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5235871076583862},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4563977122306824},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4446295499801636},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.41551434993743896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26197487115859985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10729533433914185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0901356041431427},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2374479875","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHXX200403004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764975887","display_name":"Zhonghua xinxueguanbing zazhi","issn_l":"0253-3758","issn":["0253-3758"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua xinxueguanbing zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2038843437","https://openalex.org/W2367970726","https://openalex.org/W2387517887","https://openalex.org/W2352435349","https://openalex.org/W2390388244","https://openalex.org/W800803417","https://openalex.org/W2375352160","https://openalex.org/W2091614961","https://openalex.org/W3028640666","https://openalex.org/W2391722662"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"whether":[3],"atrial":[4,26,178,187,201,213],"expression":[5,53,148,172],"of":[6,16,31,95,149,173,195,212,230],"the":[7,17,45,66,193,210,228],"extracellular":[8],"signal":[9],"regulated":[10],"kinase":[11],"(ERK":[12],"1/ERK":[13,175,198],"2)":[14],"and":[15,72,84,121,142,181],"angiotensin":[18],"converting":[19],"enzyme(ACE)":[20],"is":[21],"altered":[22],"in":[23,101,127,155,177,192,200,215],"patients":[24,33,102,128,133,156,162,216],"with":[25,34,103,129,134,157,163,167,217],"fibrillation(AF).":[27],"Methods":[28],"A":[29],"total":[30],"52":[32],"rheumatic":[35],"heart":[36,50],"disease":[37],"were":[38,86,99,124],"examined.":[39],"Atrial":[40],"tissue":[41,75,188],"was":[42,54,145,151],"obtained":[43],"from":[44],"right":[46],"appendage":[47],"during":[48],"open":[49],"surgery.":[51],"ERK":[52,79,96,118,174,197],"analyzed":[55,87],"at":[56,73],"mRNA":[57,98],"level":[58,68,76],"by":[59,69,77,88],"reverse":[60],"transcription":[61],"polymerase":[62],"chain":[63],"reaction(RT":[64],"PCR),at":[65],"protein":[67],"Western":[70,89],"blotting":[71,90],"artial":[74],"immunohistochemistry.":[78],"activating":[80],"kinase(MEK":[81],"1\u30012":[82,123],")":[83],"ACE":[85,150,189],"techniques.":[91],"Results":[92],"Increased":[93],"amounts":[94,194],"2":[97,120,176,199],"found":[100],"chronic":[104,140,158],"AF[":[105],"(76.1\u00b119":[106],"7)U":[107],"vs":[108],"sinus":[109,135,164],"rhythm:":[110],"(30":[111],"9\u00b124":[112],"0)U;":[113],"P":[114],"0":[115],"05].":[116],"Activated":[117],"1\u3001ERK":[119],"MEK":[122],"significantly":[125],"increased":[126,154,171],"AF":[130,141,144,159,168,218],"compared":[131,160],"to":[132,161],"rhythm.":[136,165],"No":[137],"difference":[138],"between":[139],"paroxymal":[143],"found.":[146],"The":[147],"three":[152],"fold":[153],"Patients":[166],"showed":[169],"an":[170,224],"interstitial":[179,202],"cells":[180,203],"marked":[182],"fibrotic":[183],"tissues.":[184],"Conclusions":[185],"An":[186],"dependent":[190],"increase":[191],"activated":[196],"may":[204,222],"be":[205],"a":[206],"molecular":[207],"mechanism":[208],"for":[209],"development":[211],"fibrosis":[214],".":[219],"These":[220],"findings":[221],"have":[223],"important":[225],"impact":[226],"on":[227],"treatment":[229],"AF.":[231]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}