{"id":"https://openalex.org/W2374439693","doi":null,"title":"[Morphologic diagnosis and onset characteristics of acute leukemia: a retrospective analysis of 233 cases in 10 years].","display_name":"[Morphologic diagnosis and onset characteristics of acute leukemia: a retrospective analysis of 233 cases in 10 years].","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2374439693","mag":"2374439693","pmid":"https://pubmed.ncbi.nlm.nih.gov/22931636"},"language":"zh","primary_location":{"id":"pmid:22931636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22931636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063328758","display_name":"Yi Liu","orcid":"https://orcid.org/0000-0003-0169-1125","observed_orcids":["https://orcid.org/0000-0003-0169-1125","https://orcid.org/0000-0002-4998-5547","https://orcid.org/0009-0009-4812-6968"]},"institutions":[{"id":"https://openalex.org/I4210140386","display_name":"PLA Navy General Hospital","ror":"https://ror.org/036dyz052","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140386"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["Department of Hematology, Navy General Hospital of Chinese PLA, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Navy General Hospital of Chinese PLA, Beijing, China","institution_ids":["https://openalex.org/I4210140386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106223151","display_name":"You-Zhang Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"You-Zhang Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Zhong Gong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Zhong Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109319742","display_name":"Jian Nong Cen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Cen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040712843","display_name":"Lixin Wang","orcid":"https://orcid.org/0000-0002-1379-3906","observed_orcids":["https://orcid.org/0000-0002-1379-3906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Xin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Xiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Xiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020026766","display_name":"Weina Ma","orcid":"https://orcid.org/0000-0002-6077-904X","observed_orcids":["https://orcid.org/0000-0002-6077-904X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Na Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010851719","display_name":"Xiangfeng Tang","orcid":"https://orcid.org/0000-0002-0672-6983","observed_orcids":["https://orcid.org/0000-0002-0672-6983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang-Feng Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110784440","display_name":"Nan-Hai Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan-Hai Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103896839","display_name":"Xiaojun Gong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Jun Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043233892","display_name":"Wenjie Yin","orcid":"https://orcid.org/0000-0003-2601-5895","observed_orcids":["https://orcid.org/0000-0003-2601-5895"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Jie Yin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112081415","display_name":"Defeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De-Feng Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100633302","display_name":"Xiaopeng Liu","orcid":"https://orcid.org/0000-0001-9856-0150","observed_orcids":["https://orcid.org/0000-0001-9856-0150","https://orcid.org/0009-0006-1570-4512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Peng Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062014376","display_name":"Xiaoshan Hu","orcid":"https://orcid.org/0009-0008-6896-3782","observed_orcids":["https://orcid.org/0009-0008-6896-3782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Shan Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021864129","display_name":"Jianliang Shen","orcid":"https://orcid.org/0000-0001-7899-0137","observed_orcids":["https://orcid.org/0000-0001-7899-0137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Liang Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26468015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"4","first_page":"823","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":1.0},{"id":"https://openalex.org/keywords/morphological-diagnosis","display_name":"morphological diagnosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.550000011920929},{"id":"https://openalex.org/keywords/misdiagnosis","display_name":"misdiagnosis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"immunophenotyping","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/blast-percentage","display_name":"blast percentage","score":0.5049999952316284},{"id":"https://openalex.org/keywords/age-and-sex-distribution","display_name":"age and sex distribution","score":0.6700000166893005},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.6470000147819519},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.5756940245628357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5424214005470276},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.47761672735214233},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.46335744857788086},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44298121333122253},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4138632118701935},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4048137068748474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39305394887924194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2349223494529724},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0685628354549408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008967","descriptor_name":"Molecular Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020732","descriptor_name":"Cytogenetic Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22931636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22931636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"},{"id":"mag:2374439693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22931636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3013776237","https://openalex.org/W3031203270","https://openalex.org/W7115688132","https://openalex.org/W7213656124","https://openalex.org/W1639849294","https://openalex.org/W2111789585","https://openalex.org/W2348204884","https://openalex.org/W7196945212","https://openalex.org/W2810816327","https://openalex.org/W2373976258"],"abstract_inverted_index":{"The":[0,44,95,114,206,248],"objective":[1],"of":[2,10,21,31,39,46,57,80,91,103,116,165,176,250,295,307],"this":[3],"study":[4],"was":[5,86,93,112,119,167,178,209,259],"to":[6,17,34,203,299],"evaluate":[7],"the":[8,19,36,64,78,88,100,162,173,253,265,272,292,300,311],"value":[9,290],"morphologic":[11,22,65,81,110,285],"diagnosis":[12,23,30,82,85,108,111,286,294],"for":[13,211,214,217,220,223,226,229,232,235,238,241,245],"acute":[14],"leukemia":[15],"(AL),":[16],"explore":[18],"relation":[20],"with":[24,83,109,274],"immunology,":[25,104],"cytogenetics":[26],"and":[27,33,49,67,70,149,156,243,279,304],"molecular":[28,71,106],"biology":[29,107],"AL":[32,40,58,92,184,196,308],"analyze":[35],"onset":[37,89,305],"characteristics":[38,90,306],"in":[41,169,180,188,192,198,252,264,291],"10":[42],"years.":[43,205],"samples":[45],"bone":[47],"marrow":[48],"peripheral":[50],"blood":[51],"from":[52,201],"233":[53,160],"newly":[54],"diagnosed":[55],"cases":[56],"were":[59,75],"collected":[60],"during":[61],"2001-2011":[62],"years;":[63],"examination":[66,73],"immunologic,":[68],"cytogenetic":[69],"biologic":[72],"(ICM)":[74],"carried":[76],"out,":[77],"consistency":[79],"ICM":[84],"compared,":[87],"analyzed.":[94],"results":[96],"showed":[97],"that:":[98],"(1)":[99],"consistent":[101,117],"rate":[102],"cytogenetics,":[105],"84.3%.":[113],"order":[115],"rat":[118],"AUL,":[120,145,212],"M0":[121],"<":[122,124,126,128,130,132,134,136],"M1":[123,170],"HAL":[125,150],"M4":[127,155],"M2":[129,181],"M3":[131],"M5":[133],"ALL":[135,148,242],"M6,":[137,233],"M7,":[138,236],"AP;":[139],"(2)":[140],"Misdiagnosis":[141],"always":[142],"occurred":[143,185,197],"among":[144,152],"M0,":[146,215],"M1,":[147,218,275],"or":[151],"M2a,":[153],"M3v,":[154],"M5.":[157,280],"(3)":[158],"In":[159],"cases,":[161],"highest":[163],"ratio":[164,175],"blast":[166,177],"observed":[168,179],"(92.5%),":[171],"while":[172],"lowest":[174],"(49.5%).":[182],"(4)":[183],"more":[186],"frequently":[187],"males":[189],"than":[190,262],"that":[191,263,284],"female":[193],"(147:86).":[194],"(5)":[195],"patients":[199,251,273],"aged":[200],"1":[202],"88":[204],"median":[207],"age":[208],"41.5":[210],"40.8":[213],"43.4":[216],"46.3":[219],"M2,":[221,276],"33.8":[222],"M3,":[224,277],"42.6":[225],"M4,":[227,278],"48.8":[228],"M5,":[230],"77.3":[231],"2.5":[234],"65.0":[237],"AP,":[239],"29.1":[240],"40.3":[244],"HAL.":[246],"(6)":[247],"number":[249],"later":[254],"five":[255,267],"years":[256,268],"(139":[257],"cases)":[258],"significantly":[260],"greater":[261],"first":[266],"(94":[269],"cases),":[270],"especially":[271],"It":[281],"is":[282],"concluded":[283],"has":[287],"important":[288],"clinical":[289],"MICM":[293],"AL.":[296],"Attaching":[297],"importance":[298],"confusing":[301],"cell":[302],"morphology":[303],"can":[309],"improve":[310],"diagnostic":[312],"accuracy.":[313]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}