{"id":"https://openalex.org/W2374040219","doi":null,"title":"Determination of valproic acid in serum by reversed-phase high-performance liquid chromatography","display_name":"Determination of valproic acid in serum by reversed-phase high-performance liquid chromatography","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2374040219","mag":"2374040219"},"language":"en","primary_location":{"id":"mag:2374040219","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYZ200108003.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764621253","display_name":"Chinese Journal of Hospital Pharmacy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323237960","host_organization_name":"Chinese Journal of Hospital Pharmacy editorial department","host_organization_lineage":["https://openalex.org/P4323237960"],"host_organization_lineage_names":["Chinese Journal of Hospital Pharmacy editorial department"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Hospital Pharmacy","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhan Chen","orcid":"https://orcid.org/0000-0001-8687-8348","observed_orcids":["https://orcid.org/0000-0001-8687-8348"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhan Chen","raw_affiliation_strings":["Fang, HU Chao  Xin, WANG Zhi  Yan, et al"],"raw_orcid":"https://orcid.org/0000-0001-8687-8348","affiliations":[{"raw_affiliation_string":"Fang, HU Chao  Xin, WANG Zhi  Yan, et al","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.35549423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":1.0},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9010000228881836},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/reversed-phase-hplc","display_name":"reversed-phase HPLC","score":0.8859999775886536},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5139999985694885},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.9397228956222534},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7743287086486816},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.771930456161499},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.6850875616073608},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6506783962249756},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5323771834373474},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.3235072195529938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1484076976776123},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07004645466804504},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2374040219","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYZ200108003.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764621253","display_name":"Chinese Journal of Hospital Pharmacy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323237960","host_organization_name":"Chinese Journal of Hospital Pharmacy editorial department","host_organization_lineage":["https://openalex.org/P4323237960"],"host_organization_lineage_names":["Chinese Journal of Hospital Pharmacy editorial department"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Hospital Pharmacy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2390703164","https://openalex.org/W161863289","https://openalex.org/W2391346053","https://openalex.org/W2350966111","https://openalex.org/W2378588282","https://openalex.org/W1992597784","https://openalex.org/W2350247948","https://openalex.org/W2354742956","https://openalex.org/W2054986857","https://openalex.org/W2364659887"],"abstract_inverted_index":{"OBJECTIVE":[0],"To":[1],"establish":[2],"a":[3],"reversed":[4,18],"phase":[5,19],"HPLC":[6,20],"method":[7,21,74,94],"for":[8,78,104],"routine":[9],"analysis":[10],"of":[11,45,52,82],"valproic":[12,34,53],"acid":[13,35,54],"in":[14],"human":[15],"serum.METHODS":[16],"A":[17],"is":[22,70,91,95],"applied":[23],"with":[24,40,50,85],"4":[25],"bromomethyl":[26],"7":[27],"ethoxycoumain":[28],"as":[29],"derivative":[30],"reagent":[31],"which":[32],"transformed":[33],"into":[36],"an":[37],"ester":[38],"detectable":[39],"UV":[41],"detector.RESULTS":[42],"The":[43,67,73,93],"ratio":[44],"peak":[46],"heights":[47],"correlated":[48],"linearly":[49],"concentration":[51],"ranging":[55],"from":[56],"15":[57],"to":[58],"200":[59],"\u03bcg\u00b7ml":[60],"-1":[61],",":[62],"r":[63],"=":[64],"0.9991":[65],".":[66,72],"mean":[68],"recovery":[69],"100.9%":[71],"has":[75],"been":[76],"used":[77],"therapeutic":[79],"drug":[80],"monitoring":[81],"34":[83],"patients":[84],"epilepsy":[86],"and":[87,100,102,108],"satisfied":[88],"clinical":[89,106],"effects":[90],"acquired.CONCLUSIONS":[92],"sensitive,":[96],"accurate,":[97],"selective,":[98],"simple":[99],"fast,":[101],"suitable":[103],"the":[105],"research":[107],"application.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}