{"id":"https://openalex.org/W2373943464","doi":null,"title":"Receptors,synapses and memories","display_name":"Receptors,synapses and memories","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2373943464","mag":"2373943464"},"language":"en","primary_location":{"id":"mag:2373943464","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SMKX200805006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764901949","display_name":"Shengming kexue","issn_l":"1004-0374","issn":["1004-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4360969379","host_organization_name":"National Natural Science Foundation of China","host_organization_lineage":["https://openalex.org/P4360969379"],"host_organization_lineage_names":["National Natural Science Foundation of China"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shengming kexue","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065713713","display_name":"Richard L. Huganir","orcid":"https://orcid.org/0000-0001-9783-5183","observed_orcids":["https://orcid.org/0000-0001-9783-5183"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Huganir Richard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065713713"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28315772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":1.0},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.8550000190734863},{"id":"https://openalex.org/keywords/glua2-subunit","display_name":"GluR2 subunit","score":0.7889999747276306},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":1.0},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.972000002861023},{"id":"https://openalex.org/keywords/spatial-memory","display_name":"spatial memory","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pick1","display_name":"PICK1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nsf","display_name":"NSF","score":0.5669999718666077},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.6660000085830688},{"id":"https://openalex.org/keywords/motor-learning","display_name":"motor learning","score":0.8199999928474426},{"id":"https://openalex.org/keywords/neurotransmitter-receptors","display_name":"neurotransmitter receptors","score":0.5350000262260437},{"id":"https://openalex.org/keywords/synapses","display_name":"synapses","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.8596339225769043},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.8465890884399414},{"id":"https://openalex.org/C154559735","wikidata":"https://www.wikidata.org/wiki/Q7514768","display_name":"Silent synapse","level":5,"score":0.7857460975646973},{"id":"https://openalex.org/C88272193","wikidata":"https://www.wikidata.org/wiki/Q418536","display_name":"Ion channel linked receptors","level":5,"score":0.7527667284011841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5746260285377502},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5528138875961304},{"id":"https://openalex.org/C203270574","wikidata":"https://www.wikidata.org/wiki/Q24725121","display_name":"Class C GPCR","level":5,"score":0.5378406047821045},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5347470641136169},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.534561276435852},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.5225983262062073},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49859166145324707},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.4967837631702423},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4795001149177551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4789995849132538},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.37471985816955566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2576711177825928}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2373943464","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SMKX200805006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764901949","display_name":"Shengming kexue","issn_l":"1004-0374","issn":["1004-0374"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4360969379","host_organization_name":"National Natural Science Foundation of China","host_organization_lineage":["https://openalex.org/P4360969379"],"host_organization_lineage_names":["National Natural Science Foundation of China"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shengming kexue","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165278449","https://openalex.org/W2298260555","https://openalex.org/W1997276312","https://openalex.org/W4388310408","https://openalex.org/W3087305404","https://openalex.org/W2176816948","https://openalex.org/W2151444391","https://openalex.org/W2059146082","https://openalex.org/W2049926325","https://openalex.org/W4251814690"],"abstract_inverted_index":{"Neurotransmitter":[0],"receptors":[1,39,43,64,81,98,153],"mediate":[2],"signal":[3],"transduction":[4],"at":[5,154,222],"the":[6,15,21,25,41,94,116,124,133,143,146,190,193,203,210,230,236,249,263,278,292,296,316,322],"postsynaptic":[7],"membrane":[8,85,239,251],"of":[9,27,72,79,96,104,115,126,129,135,145,151,161,178,192,196,205,213,238,256,265,275,298,307,318,331],"synaptic":[10,254,319],"connections":[11],"between":[12],"neurons":[13],"in":[14,24,40,54,88,235,248,277,321],"nervous":[16,323],"system.We":[17],"have":[18,32,57,91,139,156,173,200,259,290,303],"been":[19,141],"studying":[20],"molecular":[22,293],"mechanisms":[23,144,294],"regulation":[26,237,297,306,317],"neurotransmitter":[28,299],"receptor":[29,118,243,300,308],"function.Recently":[30],"we":[31,181],"focused":[33],"on":[34],"glutamate":[35,152],"receptors,the":[36],"major":[37,49,313],"excitatory":[38,223],"brain.Glutamate":[42],"can":[44],"be":[45,311,327],"divided":[46],"into":[47],"two":[48],"classes:AMPA":[50],"and":[51,62,84,106,131,149,170,253,267,325],"NMDA":[52,63,171],"receptors.Studies":[53],"our":[55,89],"laboratory":[56],"found":[58,174,201,221],"that":[59,93,163,180,202,219,262,280,305],"both":[60],"AMPA":[61,97,117,169,197,242],"are":[65,246],"multiply":[66],"phosphory-":[67],"lated":[68],"by":[69],"a":[70,159,175,272,282,312],"variety":[71,160],"protein":[73,215,218,233],"kinases.Phosphorylation":[74],"regulates":[75],"several":[76],"functional":[77],"properties":[78],"these":[80,127,257],"including":[82],"conductance":[83],"targeting.Recent":[86],"studies":[87,302],"lab":[90],"demonstrated":[92],"phosphorylation":[95],"is":[99,121,220,269,281],"regulated":[100],"during":[101],"cellular":[102,283],"models":[103],"learning":[105],"memory":[107],"such":[108],"as":[109],"long-":[110],"term":[111],"potentiation(LTP)and":[112],"long-term":[113],"depression(LTD).Moreover,phosphorylation":[114],"GluRI":[119],"subunit":[120,226],"required":[122,270],"for":[123,132,271,285,315],"expression":[125],"forms":[128],"plasticity":[130,320],"retention":[134],"spatial":[136],"memory.":[137],"We":[138],"also":[140,207,227],"examining":[142],"subcellular":[147],"targeting":[148,255],"clustering":[150],"synapses.We":[155],"recently":[157,260],"identified":[158],"proteins":[162,179,245],"directly":[164,187],"or":[165],"indirectly":[166],"interact":[167,208],"with":[168,209,229],"receptors.We":[172,258],"novel":[176],"family":[177],"call":[182],"GRIPs(Glutamate":[183],"Receptor":[184],"Interacting":[185],"Proteins)that":[186],"bind":[188],"to":[189],"C-termini":[191,204],"GluR2/3":[194],"subunits":[195],"receptors.In":[198],"addition,we":[199],"GluR2":[206,225],"PDZ":[211],"domain":[212],"PICK1,a":[214],"kinase":[216],"C-binding":[217],"synapses.The":[224],"interacts":[228],"NSF":[231],"protein,a":[232],"involved":[234],"fusion":[240],"events.These":[241],"interacting":[244],"critical":[247],"proper":[250],"trafficking":[252],"shown":[261],"binding":[264],"PICK1":[266],"GRIP":[268],"specific":[273],"form":[274],"LTD":[276],"cerebellum":[279],"model":[284],"motor":[286],"learning.":[287],"In":[288],"summary,we":[289],"examined":[291],"underlying":[295],"function.Our":[301],"suggested":[304],"function":[309],"may":[310,326],"mechanism":[314],"system":[324],"an":[328],"important":[329],"determinant":[330],"animal":[332],"behavior.":[333]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
