{"id":"https://openalex.org/W2373671367","doi":null,"title":"Effects of allitridin on the expression of cell cycle related genes in human cytomegalovirus infected cells","display_name":"Effects of allitridin on the expression of cell cycle related genes in human cytomegalovirus infected cells","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2373671367","mag":"2373671367"},"language":"en","primary_location":{"id":"mag:2373671367","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHWS200309026.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2756093131","display_name":"Zhonghua weishengwuxue he mianyixue zazhi","issn_l":"0254-5101","issn":["0254-5101"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua weishengwuxue he mianyixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107073478","display_name":"Li G","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Li G","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5107073478"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2123,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60428948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.746999979019165},{"id":"https://openalex.org/keywords/cell-cycle-dysregulation","display_name":"cell cycle dysregulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/hel-cells","display_name":"HEL cells","score":0.671999990940094},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.8149710297584534},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.7843279242515564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7287954092025757},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6616308689117432},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5515562891960144},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5489826202392578},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4446302354335785},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3630499243736267},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20545804500579834}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2373671367","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHWS200309026.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2756093131","display_name":"Zhonghua weishengwuxue he mianyixue zazhi","issn_l":"0254-5101","issn":["0254-5101"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua weishengwuxue he mianyixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2352499414","https://openalex.org/W2054554509","https://openalex.org/W2383974515","https://openalex.org/W2371985017","https://openalex.org/W2042947858","https://openalex.org/W2385885905","https://openalex.org/W2370259812","https://openalex.org/W3026021230","https://openalex.org/W2075774744","https://openalex.org/W2315163354"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,19,25,102,110,117,174,177,187],"expressing":[4,133,152],"profile":[5],"of":[6,22,27,37,105,112,119,153,163,190],"cell":[7,42,165,178],"cycle":[8,43,166,179],"related":[9,41,167],"genes":[10,29,82,91,107,115,122,131,144,155,168,192],"induced":[11,129,156,193],"by":[12,46,157,182,194],"human":[13],"cytomegalovirus":[14],"(HCMV)":[15],"and":[16,70,72,94,116,138],"to":[17],"determine":[18],"interfering":[20],"effects":[21],"allitridin":[23,64,128,149],"on":[24],"expression":[26,36,104,162,189],"these":[28],"in":[30,51,86,123,134,145,169],"drug-treated":[31],"infectious":[32],"cells.":[33,147],"Methods":[34],"The":[35],"239":[38],"gene":[39,48],"mRNAs":[40],"was":[44],"detected":[45],"using":[47],"chip":[49],"assay":[50],"normal":[52,73,139,146],"or":[53],"infected":[54,71,87,124,136,170],"(MOI=2.5)":[55],"HEL":[56,74],"(human":[57],"embryonic":[58],"lung":[59],"fibroblost)":[60],"cells":[61,75,88,125,137,171],"treated":[62],"with":[63],"at":[65],"72?h":[66],"after":[67],"drug":[68,100],"treatment,":[69,101],"as":[76],"controls.":[77],"Results":[78],"There":[79],"were":[80,92,97],"24":[81],"that":[83],"differentially":[84,132],"expressed":[85],"(10.04%).":[89],"Nine":[90],"up-regulated":[93],"15":[95],"ones":[96],"down-regulated.":[98],"After":[99],"differential":[103,151,161,188],"11":[106,114],"remained,":[108],"but":[109,141],"down-regulation":[111],"another":[113],"up-regulation":[118],"other":[120],"two":[121],"disappeared.":[126],"Moreover,":[127],"2":[130],"both":[135],"cells,":[140],"only":[142],"3":[143],"Altogether,":[148],"corrected":[150],"13":[154,191],"HCMV.":[158,195],"Conclusions":[159],"Significantly":[160],"some":[164],"could":[172],"be":[173],"mechanism":[175],"for":[176],"dysregulation":[180],"caused":[181],"HCMV":[183],"infection.":[184],"Allitridin,":[185],"eliminated":[186]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}