{"id":"https://openalex.org/W2373656830","doi":"https://doi.org/10.1371/journal.pone.0155104","title":"MicroRNA Regulation of Human Genes Essential for Influenza A (H7N9) Replication","display_name":"MicroRNA Regulation of Human Genes Essential for Influenza A (H7N9) Replication","publication_year":2016,"publication_date":"2016-05-11","ids":{"openalex":"https://openalex.org/W2373656830","doi":"https://doi.org/10.1371/journal.pone.0155104","mag":"2373656830","pmid":"https://pubmed.ncbi.nlm.nih.gov/27166678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4864377"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0155104","doi":"https://doi.org/10.1371/journal.pone.0155104","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0155104","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155104&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155104&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stefan Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]},{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Stefan Wolf","raw_affiliation_strings":["Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America","Institute for Glycomics, Griffith University, Gold Coast, Southport, QLD, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute for Glycomics, Griffith University, Gold Coast, Southport, QLD, Australia","institution_ids":["https://openalex.org/I11701301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357265","display_name":"Weilin Wu","orcid":"https://orcid.org/0000-0002-7517-1686","observed_orcids":["https://orcid.org/0000-0002-7517-1686"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weilin Wu","raw_affiliation_strings":["Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheryl Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Jones","raw_affiliation_strings":["Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006883539","display_name":"Olivia Perwitasari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Perwitasari","raw_affiliation_strings":["Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040747937","display_name":"Suresh Mahalingam","orcid":"https://orcid.org/0000-0003-3141-8410","observed_orcids":["https://orcid.org/0000-0003-3141-8410"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Suresh Mahalingam","raw_affiliation_strings":["Institute for Glycomics, Griffith University, Gold Coast, Southport, QLD, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Glycomics, Griffith University, Gold Coast, Southport, QLD, Australia","institution_ids":["https://openalex.org/I11701301"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053051899","display_name":"Ralph A. Tripp","orcid":"https://orcid.org/0000-0002-2924-9956","observed_orcids":["https://orcid.org/0000-0002-2924-9956"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ralph A. Tripp","raw_affiliation_strings":["Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA, United States of America","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053051899"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.2072,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.9096625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"5","first_page":"e0155104","last_page":"e0155104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h7n9-avian-influenza","display_name":"H7N9 avian influenza","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.7319999933242798},{"id":"https://openalex.org/keywords/host-gene-regulation","display_name":"host gene regulation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/lif","display_name":"LiF","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nek7","display_name":"NEK7","score":0.9940000176429749},{"id":"https://openalex.org/keywords/proinflammatory-signaling","display_name":"pro-inflammatory signaling","score":0.6370000243186951},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.7459999918937683},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6769999861717224},{"id":"https://openalex.org/keywords/influenza-h3n2","display_name":"influenza H3N2","score":0.8479999899864197},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.7250756025314331},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6628130674362183},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.6515044569969177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.626499593257904},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6058327555656433},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.5985422730445862},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5690356492996216},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5079126954078674},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5024573802947998},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.4424424171447754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3599022626876831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26376232504844666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18569514155387878},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1670636236667633},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.13605833053588867},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.13107073307037354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07185691595077515}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053605","descriptor_name":"Leukemia Inhibitory Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064766","descriptor_name":"Influenza A Virus, H7N9 Subtype","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0155104","doi":"https://doi.org/10.1371/journal.pone.0155104","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0155104","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155104&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:27166678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27166678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4864377","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4864377/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f245ac6cf0e1439a8123893aa9ea8283","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f245ac6cf0e1439a8123893aa9ea8283","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 5, p e0155104 (2016)","raw_type":"article"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/100593","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/100593","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0155104","doi":"https://doi.org/10.1371/journal.pone.0155104","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0155104","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155104&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7605218473","display_name":null,"funder_award_id":"HHSN272201400004C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8574682048","display_name":null,"funder_award_id":"HHSN272201400004C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320310224","display_name":"Georgia Research Alliance","ror":"https://ror.org/030689123"},{"id":"https://openalex.org/F4320320981","display_name":"Griffith University","ror":"https://ror.org/02sc3r913"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2373656830.pdf","grobid_xml":"https://content.openalex.org/works/W2373656830.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1603897387","https://openalex.org/W1827177868","https://openalex.org/W1911381531","https://openalex.org/W1968631483","https://openalex.org/W1968888658","https://openalex.org/W1969429069","https://openalex.org/W1978386381","https://openalex.org/W1982015385","https://openalex.org/W1982365129","https://openalex.org/W1985074341","https://openalex.org/W1997724110","https://openalex.org/W2004843657","https://openalex.org/W2008851677","https://openalex.org/W2022336933","https://openalex.org/W2028068115","https://openalex.org/W2028682409","https://openalex.org/W2035635022","https://openalex.org/W2045859246","https://openalex.org/W2065684697","https://openalex.org/W2069521996","https://openalex.org/W2070924692","https://openalex.org/W2072569775","https://openalex.org/W2091839129","https://openalex.org/W2098431098","https://openalex.org/W2106173155","https://openalex.org/W2108058168","https://openalex.org/W2118681350","https://openalex.org/W2122290210","https://openalex.org/W2128048963","https://openalex.org/W2129571206","https://openalex.org/W2129767209","https://openalex.org/W2131179865","https://openalex.org/W2138086361","https://openalex.org/W2143717515","https://openalex.org/W2147726295","https://openalex.org/W2152001527","https://openalex.org/W2153974354","https://openalex.org/W2155360970","https://openalex.org/W2172555075","https://openalex.org/W2256756668","https://openalex.org/W2318342015","https://openalex.org/W2413278624","https://openalex.org/W2520102457","https://openalex.org/W4232010119","https://openalex.org/W4366067777"],"related_works":["https://openalex.org/W6958334420","https://openalex.org/W2108058168","https://openalex.org/W2605022608","https://openalex.org/W2780228539","https://openalex.org/W2008851677","https://openalex.org/W2128048963","https://openalex.org/W7095201828","https://openalex.org/W4386084155","https://openalex.org/W3045592999","https://openalex.org/W4309436609"],"abstract_inverted_index":{"Influenza":[0],"A":[1,52,214],"viruses":[2,13,20],"are":[3],"important":[4],"pathogens":[5],"of":[6,39,44,93,101,205,211],"humans":[7,15],"and":[8,29,55,67,78,90,183,217],"animals.":[9],"While":[10],"seasonal":[11],"influenza":[12,51,142,213],"infect":[14],"every":[16],"year,":[17],"occasionally":[18],"animal-origin":[19],"emerge":[21],"to":[22,111,134,153],"cause":[23],"pandemics":[24],"with":[25,49,80,186],"significantly":[26],"higher":[27],"morbidity":[28,79],"mortality":[30,81],"rates.":[31],"In":[32,119,172,191],"March":[33],"2013,":[34],"the":[35,91,98,120,181],"public":[36],"health":[37],"authorities":[38],"China":[40],"reported":[41,62],"three":[42],"cases":[43,61],"laboratory":[45],"confirmed":[46],"human":[47,146],"infection":[48],"avian":[50],"(H7N9)":[53],"virus,":[54],"subsequently":[56],"there":[57,106],"have":[58],"been":[59],"many":[60],"across":[63],"South":[64],"East":[65],"Asia":[66],"recently":[68],"in":[69,145,163],"North":[70],"America.":[71],"Most":[72],"patients":[73],"experience":[74],"severe":[75],"respiratory":[76,147],"illness,":[77],"rates":[82],"near":[83],"40%.":[84],"No":[85],"vaccine":[86],"is":[87,95,107],"currently":[88],"available":[89],"use":[92],"antivirals":[94],"complicated":[96],"due":[97],"frequent":[99],"emergence":[100],"drug":[102,114],"resistant":[103],"strains.":[104],"Thus,":[105],"an":[108],"imminent":[109],"need":[110],"identify":[112,135],"new":[113,136],"targets":[115,139],"for":[116,201],"therapeutic":[117],"intervention.":[118],"current":[121],"study,":[122],"a":[123,154],"high-throughput":[124],"screening":[125],"(HTS)":[126],"assay":[127],"was":[128],"performed":[129],"using":[130,195],"microRNA":[131,179],"(miRNA)":[132],"inhibitors":[133],"host":[137],"miRNA":[138],"that":[140,158,177],"reduce":[141],"H7N9":[143,165],"replication":[144,166,210],"(A549)":[148],"cells.":[149],"Validation":[150],"studies":[151,194],"lead":[152],"top":[155],"hit,":[156],"hsa-miR-664a-3p,":[157],"had":[159],"potent":[160],"antiviral":[161],"effects":[162,187],"reducing":[164],"(TCID50":[167],"titers)":[168],"by":[169],"two":[170],"logs.":[171],"silico":[173],"pathway":[174],"analysis":[175],"revealed":[176],"this":[178],"targeted":[180],"LIF":[182],"NEK7":[184],"genes":[185],"on":[188],"pro-inflammatory":[189],"factors.":[190],"follow":[192],"up":[193],"siRNAs,":[196],"anti-viral":[197],"properties":[198],"were":[199],"shown":[200],"LIF.":[202],"Furthermore,":[203],"inhibition":[204],"hsa-miR-664a-3p":[206],"also":[207],"reduced":[208],"virus":[209],"pandemic":[212],"strains":[215],"H1N1":[216],"H3N2.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}