{"id":"https://openalex.org/W2373371714","doi":"https://doi.org/10.1128/msphere.00132-18","title":"Evolutionary Plasticity of AmrZ Regulation in Pseudomonas","display_name":"Evolutionary Plasticity of AmrZ Regulation in Pseudomonas","publication_year":2018,"publication_date":"2018-04-17","ids":{"openalex":"https://openalex.org/W2373371714","doi":"https://doi.org/10.1128/msphere.00132-18","mag":"2373371714","pmid":"https://pubmed.ncbi.nlm.nih.gov/29669886","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5907648"},"language":"en","primary_location":{"id":"doi:10.1128/msphere.00132-18","doi":"https://doi.org/10.1128/msphere.00132-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msphere.00132-18","pdf_url":null,"source":{"id":"https://openalex.org/S4210207018","display_name":"mSphere","issn_l":"2379-5042","issn":["2379-5042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSphere","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/msphere.00132-18","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067145615","display_name":"David A. Baltrus","orcid":"https://orcid.org/0000-0002-5166-9551","observed_orcids":["https://orcid.org/0000-0002-5166-9551"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A. Baltrus","raw_affiliation_strings":["School of Plant Sciences, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":"https://orcid.org/0000-0002-5166-9551","affiliations":[{"raw_affiliation_string":"School of Plant Sciences, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112195701","display_name":"Kevin M. Dougherty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Dougherty","raw_affiliation_strings":["School of Plant Sciences, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Plant Sciences, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112119880","display_name":"Beatriz D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatriz Diaz","raw_affiliation_strings":["School of Plant Sciences, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Plant Sciences, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014226893","display_name":"Rachel Murillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Murillo","raw_affiliation_strings":["School of Plant Sciences, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Plant Sciences, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067145615"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.073,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75023474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amrz","display_name":"AmrZ","score":0.9929999709129333},{"id":"https://openalex.org/keywords/master-regulators","display_name":"master regulators","score":0.703000009059906},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pseudomonas","display_name":"Pseudomonas","score":0.7160000205039978},{"id":"https://openalex.org/keywords/swimming-motility","display_name":"swimming motility","score":0.8270000219345093},{"id":"https://openalex.org/keywords/regulatory-evolution","display_name":"regulatory evolution","score":0.5199999809265137},{"id":"https://openalex.org/keywords/pseudomonas-stutzeri","display_name":"Pseudomonas stutzeri","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pseudomonas-syringae","display_name":"Pseudomonas syringae","score":1.0},{"id":"https://openalex.org/keywords/pseudomonas-fluorescens","display_name":"Pseudomonas fluorescens","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.8844437599182129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7389430999755859},{"id":"https://openalex.org/C2776835041","wikidata":"https://www.wikidata.org/wiki/Q135292","display_name":"Pseudomonas fluorescens","level":3,"score":0.6577131748199463},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6548871397972107},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.5914831161499023},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.515028715133667},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.5132241249084473},{"id":"https://openalex.org/C2776786877","wikidata":"https://www.wikidata.org/wiki/Q2888828","display_name":"Pseudomonas stutzeri","level":3,"score":0.5014498233795166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4891052842140198},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4805036783218384},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46896424889564514},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4668959081172943},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.4613924026489258},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4408413767814636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4114302396774292},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15954026579856873},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15233641862869263},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011549","descriptor_name":"Pseudomonas","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1128/msphere.00132-18","doi":"https://doi.org/10.1128/msphere.00132-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msphere.00132-18","pdf_url":null,"source":{"id":"https://openalex.org/S4210207018","display_name":"mSphere","issn_l":"2379-5042","issn":["2379-5042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSphere","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4850557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5907648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5907648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5907648","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSphere","raw_type":"Text"},{"id":"pmid:29669886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29669886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSphere","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/627786","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/627786","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"e00132-18","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:53a04bb6e41241dfa1127a0361e7be9f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/53a04bb6e41241dfa1127a0361e7be9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSphere, Vol 3, Iss 2, p e00132-18 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:fdc1c29b3e3b424ab87f1ea848aebd75","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fdc1c29b3e3b424ab87f1ea848aebd75","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSphere, Vol 3, Iss 2 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/msphere.00132-18","doi":"https://doi.org/10.1128/msphere.00132-18","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msphere.00132-18","pdf_url":null,"source":{"id":"https://openalex.org/S4210207018","display_name":"mSphere","issn_l":"2379-5042","issn":["2379-5042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSphere","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320313518","display_name":"University of Arizona Foundation","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1967107713","https://openalex.org/W1981183944","https://openalex.org/W1982651910","https://openalex.org/W2015483321","https://openalex.org/W2025020367","https://openalex.org/W2034598535","https://openalex.org/W2053272135","https://openalex.org/W2061578584","https://openalex.org/W2061974849","https://openalex.org/W2068872007","https://openalex.org/W2089579181","https://openalex.org/W2095033422","https://openalex.org/W2107731806","https://openalex.org/W2134412230","https://openalex.org/W2137015675","https://openalex.org/W2143415844","https://openalex.org/W2143697390","https://openalex.org/W2148698435","https://openalex.org/W2155702684","https://openalex.org/W2160253522","https://openalex.org/W2165081628","https://openalex.org/W2166017852","https://openalex.org/W2166211697","https://openalex.org/W2582743722","https://openalex.org/W2731958902","https://openalex.org/W2789284220","https://openalex.org/W2806112473","https://openalex.org/W2949374631"],"related_works":["https://openalex.org/W4241398724","https://openalex.org/W2806112473","https://openalex.org/W3185898336","https://openalex.org/W2339615184","https://openalex.org/W122028743","https://openalex.org/W2042569858","https://openalex.org/W2965654280","https://openalex.org/W7098594483","https://openalex.org/W7015443273","https://openalex.org/W2165752657"],"abstract_inverted_index":{"Microbes":[0],"often":[1],"display":[2],"finely":[3],"tuned":[4],"patterns":[5],"of":[6,21,32,49,65,67,106,133],"gene":[7,33],"regulation":[8,66],"across":[9,35],"different":[10],"environments,":[11],"with":[12],"major":[13],"regulatory":[14,109,135],"changes":[15],"controlled":[16],"by":[17,70],"a":[18,29,41,47],"small":[19],"group":[20],"\u201cmaster\u201d":[22],"regulators":[23],"within":[24],"each":[25],"cell.":[26],"AmrZ":[27,71,82,125],"is":[28],"master":[30],"regulator":[31,45,122],"expression":[34],"pseudomonads":[36],"and":[37,55,90,100],"can":[38],"be":[39],"either":[40],"positive":[42],"or":[43],"negative":[44],"for":[46,124],"variety":[48],"pathways":[50],"depending":[51],"on":[52],"the":[53,62,117,131],"strain":[54],"genomic":[56],"context.":[57],"Here,":[58],"we":[59],"demonstrate":[60],"that":[61,81],"phenotypic":[63],"outcomes":[64],"swimming":[68,85],"motility":[69,86],"have":[72],"switched":[73],"at":[74],"least":[75],"twice":[76],"independently":[77],"in":[78,87,97,108,121],"pseudomonads,":[79],"so":[80],"promotes":[83],"increased":[84],"P.":[88,91],"stutzeri":[89],"syringae":[92],"but":[93],"represses":[94],"this":[95],"phenotype":[96],"Pseudomonas":[98,101],"fluorescens":[99],"aeruginosa":[102],".":[103],"Since":[104],"examples":[105],"switches":[107],"mode":[110],"are":[111],"relatively":[112],"rare,":[113],"further":[114],"investigation":[115],"into":[116,130],"mechanisms":[118],"underlying":[119],"shifts":[120],"function":[123],"could":[126],"provide":[127],"unique":[128],"insights":[129],"evolution":[132],"bacterial":[134],"proteins.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}