{"id":"https://openalex.org/W2373127516","doi":null,"title":"The roles of CD59 gene in anti-atherosclerotic effect of C-phycocyanin","display_name":"The roles of CD59 gene in anti-atherosclerotic effect of C-phycocyanin","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2373127516","mag":"2373127516"},"language":"en","primary_location":{"id":"mag:2373127516","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-MYXZ201304007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764367629","display_name":"Immunological Journal","issn_l":"1000-8861","issn":["1000-8861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361730452","host_organization_name":"Army Medical University","host_organization_lineage":["https://openalex.org/P4361730452"],"host_organization_lineage_names":["Army Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunological Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005410786","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0003-4676-3778","observed_orcids":["https://orcid.org/0000-0003-4676-3778"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan Yang","raw_affiliation_strings":["Department of Cardiology,the Affiliated Hici Hospital of Qingdao University Medical College,Qingdao 266000,China"],"raw_orcid":"https://orcid.org/0000-0003-4676-3778","affiliations":[{"raw_affiliation_string":"Department of Cardiology,the Affiliated Hici Hospital of Qingdao University Medical College,Qingdao 266000,China","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005410786"],"corresponding_institution_ids":["https://openalex.org/I108688024"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.24597662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-phycocyanin","display_name":"C-phycocyanin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8700000047683716},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9359999895095825},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.6840000152587891},{"id":"https://openalex.org/keywords/atherosclerotic-plaque-formation","display_name":"atherosclerotic plaque formation","score":0.878000020980835},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/anti-atherosclerotic-effects","display_name":"anti-atherosclerotic effects","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C184404459","wikidata":"https://www.wikidata.org/wiki/Q5009828","display_name":"CD59","level":4,"score":0.8543429374694824},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4879126250743866},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4367883801460266},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4333907663822174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39818450808525085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3614334464073181},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35925987362861633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3371223509311676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32564055919647217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32160377502441406},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31072157621383667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27983391284942627},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1684265434741974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16607096791267395},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.06354331970214844}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2373127516","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-MYXZ201304007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764367629","display_name":"Immunological Journal","issn_l":"1000-8861","issn":["1000-8861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361730452","host_organization_name":"Army Medical University","host_organization_lineage":["https://openalex.org/P4361730452"],"host_organization_lineage_names":["Army Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunological Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089623865","https://openalex.org/W7099669024","https://openalex.org/W2538991942","https://openalex.org/W2391174756","https://openalex.org/W2534818501","https://openalex.org/W2025520104","https://openalex.org/W2133274452","https://openalex.org/W2170202743","https://openalex.org/W7139306359","https://openalex.org/W2613999293"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,50,53,84,106,119,127,133],"effects":[3],"of":[4,11,15,52,72,86,108,129,135,138],"CD59":[5,62,95,109,120],"gene":[6,20,96,110],"in":[7],"occurrence":[8],"and":[9,35,94,102,111,122],"development":[10],"atherosclerosis":[12,104],"with":[13,18,46],"presence":[14],"C-phycocyanin(CPC),40":[16],"mice":[17,39,73],"ApoE":[19],"deletion(ApoE-/-)":[21],"recruited":[22],"were":[23,44,74,79],"randomly":[24],"divided":[25],"into":[26],"four":[27],"groups:":[28],"control":[29],"group,CPC":[30],"treated":[31,33,37,45],"group,CD59":[32],"group":[34],"CPC+CD59":[36],"group.All":[38],"fed":[40],"on":[41],"high-fat":[42],"diet,and":[43],"drug":[47],"intervention":[48],"respectively.At":[49],"end":[51],"12th":[54],"week,CD59":[55],"mRNA":[56,121],"level":[57,101],"was":[58,65],"determined":[59],"by":[60,67],"RT-PCR,and":[61],"protein":[63,123],"expression":[64],"detected":[66],"Western":[68],"blot.Blood":[69],"fat":[70,100],"levels":[71],"also":[75],"determined,and":[76],"aortic":[77],"roots":[78],"taken":[80],"out":[81],"for":[82],"observing":[83],"degree":[85],"atherosclerotic":[87],"plaques":[88],"formation.We":[89],"found":[90],"that":[91],"both":[92],"CPC":[93,112],"could":[97,113,117],"lower":[98],"blood":[99],"inhibit":[103,126],"formation,and":[105],"combination":[107],"more":[114],"effective.In":[115],"addition,CPC":[116],"promote":[118],"expression,thus":[124],"further":[125],"progress":[128],"atherosclerosis,which":[130],"might":[131],"be":[132],"mechanism":[134],"anti-atherosclerosis":[136],"roles":[137],"CPC.":[139]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}