{"id":"https://openalex.org/W2372997358","doi":null,"title":"The expression of thymus and activation-regulated chemokine and the receptor in asthma mice","display_name":"The expression of thymus and activation-regulated chemokine and the receptor in asthma mice","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2372997358","mag":"2372997358"},"language":"en","primary_location":{"id":"mag:2372997358","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JJYZ200705016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764945285","display_name":"Zhonghua jizhen yixue zazhi","issn_l":"1671-0282","issn":["1671-0282"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua jizhen yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059926751","display_name":"Zheng-xia Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zheng-xia Zhang","raw_affiliation_strings":["Pediatric Respiratory Department,Yuying Children's Hospital of Wenzhou Medical College,Wenzhou 325027,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Respiratory Department,Yuying Children's Hospital of Wenzhou Medical College,Wenzhou 325027,China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059926751"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210099512"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39499092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccl17","display_name":"CCL17","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ccr4","display_name":"CCR4","score":0.9240000247955322},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ovalbumin-induced-asthma","display_name":"ovalbumin-induced asthma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.8840000033378601},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chemokine-expression","display_name":"chemokine expression","score":0.652999997138977},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pulmonary-pathology","display_name":"lung pathology","score":0.44600000977516174},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.550000011920929},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6539999842643738},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.367000013589859},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.8102966547012329},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7755706310272217},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.7152198553085327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.702130913734436},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6075610518455505},{"id":"https://openalex.org/C2775866117","wikidata":"https://www.wikidata.org/wiki/Q21102300","display_name":"CCR4","level":5,"score":0.5298839807510376},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4977767765522003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49173739552497864},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4531736969947815},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.4531668424606323},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44806963205337524},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4098086357116699},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4032849967479706},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.4009765684604645},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3454027771949768},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32895010709762573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3227829933166504},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1949062943458557},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15008863806724548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12579315900802612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05112546682357788},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2372997358","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JJYZ200705016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764945285","display_name":"Zhonghua jizhen yixue zazhi","issn_l":"1671-0282","issn":["1671-0282"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua jizhen yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161167143","https://openalex.org/W2011935189","https://openalex.org/W2352311751","https://openalex.org/W2358396218","https://openalex.org/W1986903978","https://openalex.org/W4226347943","https://openalex.org/W2032989961","https://openalex.org/W3031067714","https://openalex.org/W1999906388","https://openalex.org/W2289159109"],"abstract_inverted_index":{"Objective":[0],"To":[1],"study":[2],"the":[3,10,27,58,65,112,186,229],"role":[4],"of":[5,16,68,74,90,98,114,124,131,146,153,167,200,206,231],"thymus":[6],"and":[7,30,38,64,80,101,129,134,151,170,218],"activation-regulated":[8],"chemokine(TARC)and":[9],"chemokine":[11],"receptor":[12],"4(CCR4)on":[13],"airway":[14],"inflammation":[15],"asthma":[17,31,132,154,174,207,224],"mice.Method":[18],"Twenty":[19],"male":[20],"Balb/c":[21],"mice":[22,33,54],"were":[23,34,51,71,82,104,195],"randomly":[24],"divided":[25],"into":[26],"control":[28,141,162,181,214],"group":[29],"group.Asthma":[32],"sensitized":[35],"with":[36,42],"ovalbumin(OVA)":[37],"Al(OH)_3,and":[39],"repeatedly":[40],"challenged":[41],"aerosolized":[43],"OVA.Blood":[44],"samples,bronchoalveolar":[45],"lavage":[46],"fluid":[47],"(BALF)and":[48],"lung":[49,91,190,236],"tissues":[50,191],"collected":[52],"from":[53],"24":[55],"hours":[56],"after":[57],"last":[59],"challenge.The":[60],"total":[61],"cell":[62,66,205],"numbers":[63],"differentials":[67],"BALF":[69,79,128,150],"cells":[70],"counted.The":[72],"levels":[73,145],"TARC,and":[75],"IL-4":[76,147],"in":[77,126,140,148,161,173,180,189,202,213,222,228,235],"both":[78,127,149],"serum":[81,130,152],"measured":[83],"by":[84,106,119],"enzyme-linked":[85],"immunosorbent":[86],"assay(ELISA).The":[87],"pathological":[88],"changes":[89],"tissuewere":[92],"observed":[93],"under":[94],"light":[95],"microscopy.The":[96],"expression":[97,113,199],"TARC":[99,115,125,168,194,201,217,240],"mRNA":[100,103,169,172],"CCR4":[102,171,219],"detected":[105,118],"reverse":[107],"transcription":[108],"polymerase":[109],"chain":[110],"reaction(RT-PCR)and":[111],"protein":[116,198],"was":[117],"immunohistochemistry.":[120],"Results":[121],"The":[122],"concentrations":[123],"group[(458.36\u00b1114.98)pg/ml":[133],"(145.56\u00b128.38)pg/ml,respectively]were":[135],"markedly":[136],"higher":[137,158,177,210],"than":[138,159,178,211],"those":[139,160,179,212],"group[(5.06\u00b12.38)pg/":[142],"ml":[143],"and(73.79\u00b129.27)pg/ml,respectively],(P0.01,respectively).The":[144],"group[(35.46\u00b112.47)pg/ml":[155],"and(3.82\u00b11.12)pg/ml,respectively]were":[156],"significantly":[157,176,209],"group[(3.83\u00b11.57)pg/ml":[163],"and(0.88\u00b10.33)pg/ml,respectively](P0.01,":[164],"respectively).The":[165],"expressions":[166],"group[(1.12\u00b10.08)and(0.91\u00b10.13),respectively]were":[175],"group[(0.53\u00b10.12)and(0.62\u00b10.10),":[182],"respectively](P0.01,respectively),Immunohistochemistry":[183],"showed":[184],"that":[185,192,238],"predominant":[187,233],"ceils":[188,234],"expressed":[193,239],"epithelial":[196,204],"cells.The":[197],"bronchus":[203],"group(0.103\u00b10.015)was":[208],"group(0.045\u00b10.007)(P0.01).":[215],"Conclusions":[216],"is":[220],"up-regulated":[221],"allergic":[223],"mice,which":[225],"may":[226],"involve":[227],"development":[230],"asthma.Furthermore,the":[232],"tissue":[237],"are":[241],"bronchial":[242],"epithelium.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}