{"id":"https://openalex.org/W2372969963","doi":null,"title":"Pathophysiological function of HMGB1 as a late-acting mediator of inflammation","display_name":"Pathophysiological function of HMGB1 as a late-acting mediator of inflammation","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2372969963","mag":"2372969963"},"language":"en","primary_location":{"id":"mag:2372969963","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200507041.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo bingli shengli zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106036573","display_name":"Tang Daolin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tang Daolin","raw_affiliation_strings":["~1, KANG Rui~2, XIAO Xian-zhong~1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"~1, KANG Rui~2, XIAO Xian-zhong~1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091664811","display_name":"Rui Kang","orcid":"https://orcid.org/0000-0003-2725-1574","observed_orcids":["https://orcid.org/0000-0003-2725-1574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Kang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2725-1574","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063945649","display_name":"Xiao Xian-zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao Xian-zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23803191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"07","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.996999979019165},{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extracellular-hmgb1","display_name":"extracellular HMGB1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hmgb1-inhibition","display_name":"HMGB1 inhibition","score":0.7020000219345093},{"id":"https://openalex.org/keywords/anti-hmgb1-antibody","display_name":"anti-HMGB1 antibody","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ethyl-pyruvate","display_name":"ethyl pyruvate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/chromatin-binding-proteins","display_name":"chromatin-binding proteins","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.9799447059631348},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.8107403516769409},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8038444519042969},{"id":"https://openalex.org/C30683889","wikidata":"https://www.wikidata.org/wiki/Q926211","display_name":"High-mobility group","level":3,"score":0.7766550183296204},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6480151414871216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5739743709564209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.566800594329834},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5485294461250305},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5352516770362854},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47501716017723083},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4572273790836334},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4423849880695343},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4354499280452728},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2796117663383484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21812644600868225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15885871648788452}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2372969963","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200507041.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo bingli shengli zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079112084","https://openalex.org/W1997985212","https://openalex.org/W2352398837","https://openalex.org/W2020942709","https://openalex.org/W2016169910","https://openalex.org/W1978371085","https://openalex.org/W2133843587","https://openalex.org/W2339656438","https://openalex.org/W2018653121","https://openalex.org/W2059529139"],"abstract_inverted_index":{"High":[0],"mobility":[1],"group":[2],"box":[3],"chromosomal":[4,11],"protein":[5,20],"(HMGB1),":[6],"an":[7],"abundant":[8],"eukaryotic":[9],"nonhistone":[10],"protein,":[12],"is":[13,46],"previously":[14],"known":[15],"as":[16,38,87,134],"a":[17,39,65,96,135],"nuclear":[18],"DNA-binding":[19],"that":[21,35,91],"stabilizes":[22],"the":[23,51,121,139],"structure":[24],"and":[25,44,75,89,98,109,126],"function":[26],"of":[27,42,53,79,124,141],"chromatin,":[28],"regulates":[29],"gene":[30],"transcription.":[31],"Recent":[32],"studies":[33],"identify":[34],"extracellular":[36],"HMGB1":[37,93,107,125],"late":[40,77],"mediator":[41],"endotoxemia":[43],"sepsis.HMGB1":[45],"released":[47],"by":[48],"activated":[49],"macrophages,induces":[50],"release":[52,108],"other":[54,83],"proinflammatory":[55,84],"mediators,and":[56],"mediates":[57],"lethality":[58],"when":[59],"overexpressed.":[60],"It":[61],"may":[62,94],"also":[63],"be":[64],"key":[66],"signal":[67],"for":[68],"eliciting":[69],"immune":[70],"responses":[71],"to":[72,105],"cellular":[73],"injury":[74],"death.Moreover,the":[76],"kinetics":[78],"HMGB1,in":[80],"compared":[81],"with":[82],"cytokines":[85],"such":[86],"TNF":[88],"IL-1,suggest":[90],"targeting":[92],"provide":[95],"wide":[97],"clinically":[99],"accessible":[100],"therapeutic":[101],"window.Three":[102],"independent":[103],"strategies":[104],"inhibit":[106],"action":[110],"are":[111],"now":[112],"available:anti-HMGB1":[113],"antibodies,A":[114],"box,and":[115],"ethyl":[116],"pyruvate.":[117],"This":[118],"review":[119],"covers":[120],"general":[122],"features":[123],"progress":[127],"in":[128,138],"research":[129],"on":[130],"its":[131],"newly":[132],"role":[133],"cytokine":[136],"participating":[137],"development":[140],"sepsis.":[142]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}