{"id":"https://openalex.org/W2372962097","doi":null,"title":"Hematopoietic stem cell senescence","display_name":"Hematopoietic stem cell senescence","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2372962097","mag":"2372962097"},"language":"en","primary_location":{"id":"mag:2372962097","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YAOL200806000.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764632464","display_name":"Zhongguo yaolixue tongbao","issn_l":"1001-1978","issn":["1001-1978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4361727491","host_organization_name":"Chinese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4361727491"],"host_organization_lineage_names":["Chinese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo yaolixue tongbao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063616750","display_name":"Aimin Meng","orcid":"https://orcid.org/0000-0002-0781-1346","observed_orcids":["https://orcid.org/0000-0002-0781-1346"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aimin Meng","raw_affiliation_strings":["Peking Union Medical College,Tianjin Key Laboratory of Molecular Nuclear Medicine,Tianjin 300192,China)"],"raw_orcid":"https://orcid.org/0000-0002-0781-1346","affiliations":[{"raw_affiliation_string":"Peking Union Medical College,Tianjin Key Laboratory of Molecular Nuclear Medicine,Tianjin 300192,China)","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063616750"],"corresponding_institution_ids":["https://openalex.org/I200296433"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.28200749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9750000238418579},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hsc-exhaustion","display_name":"HSC exhaustion","score":0.8539999723434448},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7820000052452087},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.7099999785423279},{"id":"https://openalex.org/keywords/senescence-evasion","display_name":"senescence evasion","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8843767046928406},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7226795554161072},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6360946297645569},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6012117862701416},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.5887524485588074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5764858722686768},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4893342852592468},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48908883333206177},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4780624210834503},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4666350483894348},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3415793180465698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19986239075660706},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16703560948371887}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2372962097","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YAOL200806000.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764632464","display_name":"Zhongguo yaolixue tongbao","issn_l":"1001-1978","issn":["1001-1978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4361727491","host_organization_name":"Chinese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4361727491"],"host_organization_lineage_names":["Chinese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo yaolixue tongbao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7143482730","https://openalex.org/W2358097366","https://openalex.org/W4248668119","https://openalex.org/W1531414518","https://openalex.org/W2768409010","https://openalex.org/W2107768040","https://openalex.org/W2891147647","https://openalex.org/W4226066425","https://openalex.org/W4290721549","https://openalex.org/W2469412979"],"abstract_inverted_index":{"Lifelong":[0],"blood":[1],"cell":[2,70],"production":[3],"is":[4],"achieved":[5],"by":[6,61,76],"the":[7,30,41,44,64,80],"capacity":[8],"of":[9,19,33,46],"hematopoietic":[10],"stem":[11,69],"cell(HSC)":[12],"to":[13,40,51],"differentiate":[14],"and":[15,35,72],"self-renew.A":[16],"growing":[17],"body":[18],"evidence":[20],"suggest":[21],"that":[22,55],"DNA":[23],"damage":[24],"induced":[25,60],"HSC":[26,36,47,58],"senescence":[27,48],"may":[28],"be":[29],"principal":[31],"mechanism":[32],"aging":[34],"exhaustion":[37],"in":[38],"response":[39],"stress":[42],"exposure.Understanding":[43],"mechanisms":[45,66],"will":[49],"help":[50],"find":[52],"new":[53],"therapeutics":[54],"can":[56],"ameliorate":[57],"injury":[59],"chemo-and":[62],"radiotherapy,elucidate":[63],"molecular":[65,82],"whereby":[67],"leukemia/cancer":[68],"arise":[71],"evade":[73],"cancer":[74],"therapy":[75],"escaping":[77],"senescence,and":[78],"identify":[79],"novel":[81],"targets":[83],"for":[84],"intervention.":[85]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}