{"id":"https://openalex.org/W237286508","doi":null,"title":"Analgesia produced by exposure to 2450-MHz radiofrequency radiation (RFR) is mediated by brain mu- and kappa-opioid receptors","display_name":"Analgesia produced by exposure to 2450-MHz radiofrequency radiation (RFR) is mediated by brain mu- and kappa-opioid receptors","publication_year":1992,"publication_date":"1992-02-26","ids":{"openalex":"https://openalex.org/W237286508","mag":"237286508"},"language":"en","primary_location":{"id":"mag:237286508","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/7278554","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047520865","display_name":"GARY D. SALOMON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GARY D. SALOMON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079867642","display_name":"E.J. Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.J. Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015469925","display_name":"Raymond Mark Quock","orcid":"https://orcid.org/0000-0001-6616-4778","observed_orcids":["https://orcid.org/0000-0001-6616-4778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond M. Quock","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6616-4778","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01464886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiofrequency-electromagnetic-fields","display_name":"radiofrequency electromagnetic fields","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8320000171661377},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":1.0},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.8309999704360962},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9079999923706055},{"id":"https://openalex.org/keywords/beta-funaltrexamine","display_name":"beta-funaltrexamine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nor-binaltorphimine","display_name":"nor-binaltorphimine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mr-2266","display_name":"MR 2266","score":0.9190000295639038},{"id":"https://openalex.org/keywords/abdominal-constriction","display_name":"abdominal constriction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/electromagnetic-field-exposure","display_name":"electromagnetic field exposure","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C184389661","wikidata":"https://www.wikidata.org/wiki/Q14897645","display_name":"\u03ba-opioid receptor","level":4,"score":0.8344614505767822},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.7261307835578918},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6606993675231934},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.6549843549728394},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.634433388710022},{"id":"https://openalex.org/C2775962371","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Opioid antagonist","level":5,"score":0.6238520741462708},{"id":"https://openalex.org/C14397066","wikidata":"https://www.wikidata.org/wiki/Q14911924","display_name":"\u03bc-opioid receptor","level":4,"score":0.5670173764228821},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5528374910354614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5190849304199219},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.46472078561782837},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.42152461409568787},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38691839575767517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37647202610969543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27612727880477905},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.060905277729034424},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.052114635705947876}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:237286508","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/7278554","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974166955","https://openalex.org/W1556079012","https://openalex.org/W1997771816","https://openalex.org/W2954302682","https://openalex.org/W2095029167","https://openalex.org/W2066586709","https://openalex.org/W2263211806","https://openalex.org/W2013946992","https://openalex.org/W2000454681","https://openalex.org/W2277069926"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,79,107],"conducted":[3],"to":[4,22],"identify":[5],"the":[6,41,88,93,100,117],"opioid":[7,64],"receptor":[8,65],"subtype(s)":[9],"responsible":[10],"for":[11,32,69],"RFR-induced":[12,77,105,124],"analgesia.":[13],"Male":[14],"Swiss":[15],"Webster":[16],"mice,":[17],"20-25":[18],"g,":[19],"were":[20,59],"exposed":[21],"20":[23],"mW/cm{sup":[24],"2}":[25],"RFR":[26,53],"in":[27,40],"a":[28],"2,450-MHz":[29],"waveguide":[30],"system":[31],"10":[33],"min,":[34],"then":[35],"tested":[36],"15":[37],"min":[38],"later":[39],"abdominal":[42],"constriction":[43],"paradigm":[44],"which":[45],"detects":[46],"{mu}-":[47,70,131],"and":[48,98,132],"{kappa}-opioid":[49,72,102,133],"activity.":[50],"Immediately":[51],"following":[52],"exposure,":[54],"different":[55,63],"groups":[56],"of":[57,87,116],"mice":[58],"pretreated":[60],"intracerebroventricularly":[61],"with":[62,67,113],"blockers":[66],"selectivity":[68],"or":[71],"receptors.":[73],"Results":[74],"show":[75],"that":[76,123],"analgesia":[78,106,125],"attenuated":[80],"by":[81,99,110,129],"higher":[82],"but":[83,92],"not":[84],"lower":[85],"doses":[86],"non-selective":[89],"antagonist":[90,96,103],"naloxone,":[91],"selective":[94,101],"{mu}-opioid":[95],"{beta}-funaltrexamine":[97],"norbinaltorphimine.":[104],"also":[108],"reduced":[109],"subcutaneous":[111],"pretreatment":[112],"5.0":[114],"mg/kg":[115],"{mu}-/{kappa}-opioid":[118],"antagonist({minus})-5,9-diethyl-{alpha}-5,9-dialkyl-2{prime}-hydroxy-6,7-benzomorphan(MR-2266).":[119],"These":[120],"findings":[121],"suggest":[122],"may":[126],"be":[127],"mediated":[128],"both":[130],"mechanisms.":[134]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}