{"id":"https://openalex.org/W2372859404","doi":null,"title":"Decreased expression of TPH2 in median raphe nuclei of ovariectomized depression model rats","display_name":"Decreased expression of TPH2 in median raphe nuclei of ovariectomized depression model rats","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2372859404","mag":"2372859404"},"language":"en","primary_location":{"id":"mag:2372859404","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JCYL201011012.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764999633","display_name":"Basic & Clinical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4324341401","host_organization_name":"Beijing Association for Physiological Sciences","host_organization_lineage":["https://openalex.org/P4324341401"],"host_organization_lineage_names":["Beijing Association for Physiological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Basic & Clinical Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101081734","display_name":"Min Jian-xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10899854","display_name":"Jiangxi University of Traditional Chinese Medicine","ror":"https://ror.org/03jy32q83","country_code":"CN","type":"education","lineage":["https://openalex.org/I10899854"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Min Jian-xin","raw_affiliation_strings":["College of Basic Medical Science,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medical Science,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)","institution_ids":["https://openalex.org/I10899854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101081734"],"corresponding_institution_ids":["https://openalex.org/I10899854"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.2645661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.15539999306201935,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan-hydroxylase-2","display_name":"tryptophan hydroxylase 2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/depression-model","display_name":"depression model","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.949999988079071},{"id":"https://openalex.org/keywords/female-rats","display_name":"female rats","score":0.7929999828338623},{"id":"https://openalex.org/keywords/serotonin-synthesis","display_name":"serotonin synthesis","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2779999352","wikidata":"https://www.wikidata.org/wiki/Q18049432","display_name":"TPH2","level":5,"score":0.9783544540405273},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.855910062789917},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.7629481554031372},{"id":"https://openalex.org/C2777615928","wikidata":"https://www.wikidata.org/wiki/Q26261774","display_name":"Raphe","level":5,"score":0.6937522292137146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6705372333526611},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6660162210464478},{"id":"https://openalex.org/C2777865548","wikidata":"https://www.wikidata.org/wiki/Q2061493","display_name":"Raphe nuclei","level":5,"score":0.6631616950035095},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5911902189254761},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5179440379142761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36085277795791626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33534467220306396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2872624397277832},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12914839386940002},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.10329452157020569},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.06081116199493408}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2372859404","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JCYL201011012.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764999633","display_name":"Basic & Clinical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4324341401","host_organization_name":"Beijing Association for Physiological Sciences","host_organization_lineage":["https://openalex.org/P4324341401"],"host_organization_lineage_names":["Beijing Association for Physiological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Basic & Clinical Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030326564","https://openalex.org/W2356691071","https://openalex.org/W2749053427","https://openalex.org/W2074312709","https://openalex.org/W2005076717","https://openalex.org/W2012223420","https://openalex.org/W3032451024","https://openalex.org/W2094015561","https://openalex.org/W2271466033","https://openalex.org/W2940413096"],"abstract_inverted_index":{"Objective":[0],"To":[1],"identify":[2],"changes":[3],"of":[4,7,14,27,38,83,97,111,117,129,135,159,162,172,174,185],"the":[5,12,23,36,58,80,124,133,170,183],"concentration":[6,116],"5-hydroxytryptamine(5-HT)":[8,68],"in":[9,18,22,43,69,90,102,107,119,123,139,154,164,176],"hippocampus":[10,120,165],"and":[11,74,86,100,132],"expression":[13,82,128,173],"tryptophan":[15],"hydroxylase":[16],"2(TPH2)":[17],"median":[19,91,177],"raphe":[20,92,140,178],"nuclei":[21,141],"ovariectomized":[24],"depression":[25,146],"model":[26,31,103,125,147],"rats.Methods":[28],"The":[29],"animal":[30],"was":[32,54,64,114,121],"established":[33],"by":[34,152],"resecting":[35],"ovaries":[37],"female":[39],"rats,then":[40],"giving":[41],"isolation-housing":[42],"combination":[44,155],"with":[45,156],"chronic":[46],"unexpected":[47],"mild":[48],"stress(CUMS)":[49],"for":[50],"21":[51,95,157],"days.Behavioral":[52],"test":[53],"used":[55,77],"to":[56,66,78,169,181],"evaluate":[57],"model.High":[59],"performance":[60],"liquid":[61],"chromatogram-electrochemical":[62],"detection":[63],"employed":[65],"measure":[67],"hippocampus.Reverse":[70],"transcription-polymerase":[71],"chain":[72],"reaction(RT-PCR)":[73],"immunohistochemistry":[75],"were":[76,105,142],"detect":[79],"relative":[81,127],"TPH2":[84,87,130,136,175],"mRNA":[85,131],"immunoreactive":[88,137],"neurons":[89,138],"nuclei.Results":[93],"After":[94],"days":[96,158],"CUMS,both":[98],"crossing":[99],"rearing":[101],"group":[104],"reduced":[106],"Open-Field":[108],"test,and":[109],"percentage":[110],"sugar":[112],"consumption":[113],"decreased.The":[115],"5-HT":[118,163],"lowered":[122],"one,the":[126],"number":[134],"decreased":[143],"too.Conclusion":[144],"Ovariectomized":[145],"could":[148],"successfully":[149],"be":[150,167],"induced":[151],"ovariectomy,isolation-housing":[153],"CUMS.The":[160],"decrease":[161],"might":[166],"due":[168],"reducing":[171],"nuclei,which":[179],"leads":[180],"lower":[182],"synthesis":[184],"5-HT.":[186]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}