{"id":"https://openalex.org/W2372500765","doi":"https://doi.org/10.1117/12.2214474","title":"The role of membrane dynamics in electrical and infrared neural stimulation","display_name":"The role of membrane dynamics in electrical and infrared neural stimulation","publication_year":2016,"publication_date":"2016-05-13","ids":{"openalex":"https://openalex.org/W2372500765","doi":"https://doi.org/10.1117/12.2214474","mag":"2372500765"},"language":"en","primary_location":{"id":"doi:10.1117/12.2214474","doi":"https://doi.org/10.1117/12.2214474","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2214474","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089437743","display_name":"Erick Moen","orcid":"https://orcid.org/0000-0002-5947-7044","observed_orcids":["https://orcid.org/0000-0002-5947-7044"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erick K. Moen","raw_affiliation_strings":["Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021428334","display_name":"Hope T. Beier","orcid":"https://orcid.org/0000-0002-6291-118X","observed_orcids":["https://orcid.org/0000-0002-6291-118X"]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope T. Beier","raw_affiliation_strings":["Air Force Research Lab. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Lab. (United States)","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081819626","display_name":"Bennett L. Ibey","orcid":"https://orcid.org/0000-0002-7880-3837","observed_orcids":["https://orcid.org/0000-0002-7880-3837"]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett L. Ibey","raw_affiliation_strings":["Air Force Research Lab. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Lab. (United States)","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101679309","display_name":"Andrea M. Armani","orcid":"https://orcid.org/0000-0001-9890-5104","observed_orcids":["https://orcid.org/0000-0001-9890-5104"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea M. Armani","raw_affiliation_strings":["Univ. of Southern California (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Southern California (United States)","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.03552207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9719","issue":null,"first_page":"97190E","last_page":"97190E"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.14100000262260437,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.13850000500679016,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-dynamics","display_name":"membrane dynamics","score":0.7990000247955322},{"id":"https://openalex.org/keywords/infrared-neural-stimulation","display_name":"infrared neural stimulation","score":0.953000009059906},{"id":"https://openalex.org/keywords/nanosecond-pulsed-electric-fields","display_name":"nanosecond pulsed electric fields","score":0.8379999995231628},{"id":"https://openalex.org/keywords/membrane-poration","display_name":"membrane poration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/second-harmonic-generation-microscopy","display_name":"second harmonic generation microscopy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/membrane-damage","display_name":"membrane damage","score":0.5040000081062317},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cho-k1-cells","display_name":"CHO-K1 cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9549999833106995},{"id":"https://openalex.org/keywords/temperature-gradient","display_name":"temperature gradient","score":0.628000020980835},{"id":"https://openalex.org/keywords/two-photon-fluorescence","display_name":"two-photon fluorescence","score":0.5299999713897705},{"id":"https://openalex.org/keywords/optical-neural-stimulation","display_name":"optical neural stimulation","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C51141536","wikidata":"https://www.wikidata.org/wiki/Q838801","display_name":"Nanosecond","level":3,"score":0.6866904497146606},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5424424409866333},{"id":"https://openalex.org/C158355884","wikidata":"https://www.wikidata.org/wiki/Q11388","display_name":"Infrared","level":2,"score":0.5132119655609131},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4922610819339752},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.47226133942604065},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4388648271560669},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.426454097032547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39506399631500244},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34629905223846436},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3366534113883972},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.32713907957077026},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22722959518432617},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.21613949537277222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18287402391433716},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.2214474","doi":"https://doi.org/10.1117/12.2214474","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2214474","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"},{"id":"https://openalex.org/F4320337792","display_name":"Air Force Surgeon General","ror":null},{"id":"https://openalex.org/F4320338279","display_name":"Air Force Office of Scientific Research","ror":"https://ror.org/011e9bt93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1969491501","https://openalex.org/W1973526984","https://openalex.org/W1983140929","https://openalex.org/W2006022252","https://openalex.org/W2058367304","https://openalex.org/W2073162525","https://openalex.org/W2113897823","https://openalex.org/W2114144028","https://openalex.org/W2140031668","https://openalex.org/W2162969547","https://openalex.org/W2167279371","https://openalex.org/W6642638898"],"related_works":["https://openalex.org/W2073162525","https://openalex.org/W2912773903","https://openalex.org/W3165109442","https://openalex.org/W1983140929","https://openalex.org/W4221079170","https://openalex.org/W7095292590","https://openalex.org/W2293130323","https://openalex.org/W4220782359","https://openalex.org/W2085122198","https://openalex.org/W4200576450"],"abstract_inverted_index":{"We":[0,150],"recently":[1],"developed":[2],"a":[3,64,83,182,192],"nonlinear":[4],"optical":[5],"imaging":[6],"technique":[7,23,134],"based":[8],"on":[9,159],"second":[10],"harmonic":[11],"generation":[12],"(SHG)":[13],"to":[14,26,108,125,135,164,177,187,203],"identify":[15],"membrane":[16,32,111,139],"disruption":[17],"events":[18,47],"in":[19,29,82,190],"live":[20],"cells.":[21],"This":[22],"was":[24],"used":[25],"detect":[27],"nanoporation":[28],"the":[30,52,69,90,154],"plasma":[31],"following":[33],"nanosecond":[34],"pulsed":[35],"electric":[36],"field":[37],"(nsPEF)":[38],"exposure.":[39],"It":[40],"has":[41],"been":[42],"hypothesized":[43],"that":[44],"similar":[45],"poration":[46,180],"could":[48],"be":[49],"induced":[50],"by":[51,56,152],"thermal":[53,204],"gradients":[54],"generated":[55],"infrared":[57,95],"(IR)":[58],"laser":[59],"energy.":[60],"Optical":[61],"pulses":[62,158,186],"are":[63,74,99],"highly":[65,84],"desirable":[66],"stimulus":[67],"for":[68],"nervous":[70],"system,":[71],"as":[72,181],"they":[73],"capable":[75],"of":[76,105,156,170,184],"inhibiting":[77],"and":[78,113,144,196],"producing":[79],"action":[80],"potentials":[81],"localized":[85],"but":[86],"non-contact":[87],"fashion.":[88],"However,":[89],"underlying":[91],"mechanisms":[92],"involved":[93],"with":[94,147],"neural":[96],"stimulation":[97],"(INS)":[98],"not":[100],"well":[101],"understood.":[102],"The":[103,168],"ability":[104],"our":[106,133],"method":[107],"non-invasively":[109],"measure":[110],"structure":[112,140],"transmembrane":[114],"potential":[115],"via":[116],"Two":[117],"Photon":[118],"Fluorescence":[119],"(TPF)":[120],"make":[121],"it":[122,146],"uniquely":[123],"suited":[124],"neurological":[126],"research.":[127],"In":[128],"this":[129],"work,":[130],"we":[131],"leverage":[132],"understand":[136],"what":[137],"role":[138],"plays":[141],"during":[142],"INS":[143],"contrast":[145],"nsPEF":[148,188],"stimulation.":[149],"begin":[151],"examining":[153],"effect":[155],"IR":[157,185],"CHO-K1":[160],"cells":[161],"before":[162],"progressing":[163],"primary":[165],"hippocampal":[166],"neurons.":[167],"use":[169],"these":[171],"two":[172],"cell":[173,194],"lines":[174],"allows":[175],"us":[176],"directly":[178],"compare":[179],"result":[183],"exposure":[189],"both":[191],"neuron-derived":[193],"line,":[195],"one":[197],"likely":[198],"lacking":[199],"native":[200],"channels":[201],"sensitive":[202],"stimuli.":[205]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}