{"id":"https://openalex.org/W2372495443","doi":null,"title":"Experimental research of L-arginine in the treatment of acute hemorrhagic necrotizing pancreatitis in early stage","display_name":"Experimental research of L-arginine in the treatment of acute hemorrhagic necrotizing pancreatitis in early stage","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2372495443","mag":"2372495443"},"language":"en","primary_location":{"id":"mag:2372495443","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GDYW200204015.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764902613","display_name":"Journal of Hepatopancreatobiliary Surgery","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hepatopancreatobiliary Surgery","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441917","display_name":"Xiang 'Anthony' Chen","orcid":"https://orcid.org/0000-0002-2499-8261","observed_orcids":["https://orcid.org/0000-0002-2499-8261"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["jian,ZHANG Qi  yu,CHEN Bi  cheng"],"raw_orcid":"https://orcid.org/0000-0002-2499-8261","affiliations":[{"raw_affiliation_string":"jian,ZHANG Qi  yu,CHEN Bi  cheng","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100441917"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34353249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-hemorrhagic-necrotizing-pancreatitis","display_name":"acute hemorrhagic necrotizing pancreatitis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/early-treatment","display_name":"early treatment","score":0.7260000109672546},{"id":"https://openalex.org/keywords/sodium-taurocholate-induced-pancreatitis","display_name":"sodium taurocholate-induced pancreatitis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7440000176429749},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.5429999828338623},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8399999737739563},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9629999995231628},{"id":"https://openalex.org/keywords/serum-amylase","display_name":"serum amylase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pancreatic-histopathology","display_name":"pancreatic histopathology","score":0.6340000033378601},{"id":"https://openalex.org/keywords/anisodamine","display_name":"anisodamine","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7530804872512817},{"id":"https://openalex.org/C2910062394","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Necrotizing pancreatitis","level":3,"score":0.7457912564277649},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.6882137060165405},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.5916552543640137},{"id":"https://openalex.org/C2779960720","wikidata":"https://www.wikidata.org/wiki/Q668063","display_name":"Pancreatic duct","level":3,"score":0.5093980431556702},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5083453059196472},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.502758264541626},{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.49772265553474426},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.49321502447128296},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4416932463645935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4307779371738434},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35457077622413635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10922476649284363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09062120318412781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08748987317085266},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07085484266281128},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2372495443","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GDYW200204015.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764902613","display_name":"Journal of Hepatopancreatobiliary Surgery","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hepatopancreatobiliary Surgery","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2351982586","https://openalex.org/W2373156149","https://openalex.org/W2382486402","https://openalex.org/W2375418358","https://openalex.org/W2374721112","https://openalex.org/W2321903686","https://openalex.org/W2358124812","https://openalex.org/W1524565530","https://openalex.org/W2009364795","https://openalex.org/W4392619554"],"abstract_inverted_index":{"Objective:To":[0],"investigate":[1],"the":[2,49,81],"treatment":[3],"of":[4,25,52,56,62,70,77,83,88],"acute":[5,63,93],"necrotizing":[6,65,95],"pancreatitis":[7,66,96],"with":[8,33],"L":[9,34,57,89],"arginine":[10],"in":[11,18,29,59,97],"early":[12,60,98],"stage.Methods:AHNP":[13],"animal":[14],"model":[15],"was":[16],"developed":[17],"adult":[19],"SD":[20],"rat":[21],"by":[22],"retrograde":[23],"injection":[24],"3.5%":[26],"sodium":[27],"taurocholate":[28],"pancreatic":[30,84],"duct.":[31],"Injected":[32],"arginine,normal":[35],"saline":[36],"anisodamine,the":[37],"serum":[38,44,71,78],"amylase,serum":[39],"IL":[40,79],"6,serum":[41],"MDA":[42],"and":[43,48],"NO2/NO3":[45],"were":[46,54],"determined":[47],"histological":[50],"changes":[51,86],"pancreas":[53],"observed.Results:Administration":[55],"arg":[58,90],"stage":[61],"hemorrhagic":[64,94],"cound":[67],"upgrade":[68],"level":[69,76],"NO,scarenge":[72],"oxygen":[73],"free":[74],"radical,reduce":[75],"6,amylase,alleviate":[80],"sevevity":[82],"pathological":[85],"notably.Conclusion:Administration":[87],"might":[91],"treat":[92],"stage.":[99]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}