{"id":"https://openalex.org/W2372077932","doi":null,"title":"[Peripheral blood mRNA and interferon gene expression in systemic lupus erythematosus].","display_name":"[Peripheral blood mRNA and interferon gene expression in systemic lupus erythematosus].","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2372077932","mag":"2372077932","pmid":"https://pubmed.ncbi.nlm.nih.gov/15840221"},"language":"zh","primary_location":{"id":"pmid:15840221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15840221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua nei ke za zhi","raw_type":"English Abstract"},"parent_works":[],"lineage":["https://openalex.org/W2372077932"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025709046","display_name":"Jianping Tang","orcid":"https://orcid.org/0000-0003-4629-7631","observed_orcids":["https://orcid.org/0000-0003-4629-7631"]},"institutions":[{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-ping Tang","raw_affiliation_strings":["Shanghai Clinical Center of Rheumatic Diseases and Institute of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Clinical Center of Rheumatic Diseases and Institute of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China","institution_ids":["https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111726341","display_name":"Yueying Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue-ying Gu","raw_affiliation_strings":["Email: shennand@online"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Email: shennand@online","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112527481","display_name":"Nan Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028828620","display_name":"Jie Qian","orcid":"https://orcid.org/0000-0003-2117-6163","observed_orcids":["https://orcid.org/0000-0003-2117-6163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Qian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101555554","display_name":"Xiaoxiang Chen","orcid":"https://orcid.org/0000-0002-5183-1029","observed_orcids":["https://orcid.org/0000-0002-5183-1029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-xiang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112686515","display_name":"Xinfang Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-fang Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112132428","display_name":"Xiangyang Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang-yang Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060895229","display_name":"Dong Chun Liang","orcid":"https://orcid.org/0000-0002-1307-141X","observed_orcids":["https://orcid.org/0000-0002-1307-141X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101548584","display_name":"Qiang Guo","orcid":"https://orcid.org/0000-0001-8742-5199","observed_orcids":["https://orcid.org/0000-0001-8742-5199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061622549","display_name":"Chengde Yang","orcid":"https://orcid.org/0000-0002-3720-634X","observed_orcids":["https://orcid.org/0000-0002-3720-634X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng-de Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Chun-de Bao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun-de Bao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021295149","display_name":"Shun\u2010le Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shun-le Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1763,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53760519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"2","first_page":"106","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.6439999938011169},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/interferon-omega","display_name":"interferon omega","score":0.9810000061988831},{"id":"https://openalex.org/keywords/interferon-expression","display_name":"interferon gene expression","score":0.8700000047683716},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/interferon-score","display_name":"interferon score","score":0.6869999766349792},{"id":"https://openalex.org/keywords/disease-specificity","display_name":"disease specificity","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.85145103931427},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5396066308021545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5094648003578186},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49638134241104126},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.47488754987716675},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.46819978952407837},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.45944109559059143},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.44629886746406555},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.42944854497909546},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4267571270465851},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.42239201068878174},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3839396834373474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3774597644805908},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.1801832914352417},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13528984785079956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08996608853340149},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15840221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15840221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua nei ke za zhi","raw_type":"English Abstract"},{"id":"mag:2372077932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15840221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2348311475","https://openalex.org/W2977500809","https://openalex.org/W2158635228","https://openalex.org/W1965672602","https://openalex.org/W2387173286","https://openalex.org/W2039378822","https://openalex.org/W135819538","https://openalex.org/W1027374066","https://openalex.org/W2042312470","https://openalex.org/W2136590838"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,17,56,83,96,101,323,333,345],"expression":[4,35,84,105,117,141,159,184,224,311,336],"levels":[5,36,85,106,118,142,160,185,225,250,312],"of":[6,20,86,103,119,161,186,199,226,251,275,295,313,325,329,338,347,354],"interferon":[7],"(IFN)-alpha,":[8],"-beta,":[9,315],"-omega":[10,316],"and":[11,14,27,49,58,67,93,107,110,183,234,254,292,317],"-gamma":[12,318],"genes":[13],"proteins":[15],"in":[16,89,95,123,132,138,143,151,165,174,181,190,207,216,230,246,256,265,271,277,285,302,306,322,344],"peripheral":[18],"blood":[19,63],"patients":[21,46,90,125,145,168,177,191,209,233,257],"with":[22,37,47,91,192,197,240,258],"systemic":[23],"lupus":[24],"erythematosus":[25],"(SLE),":[26],"to":[28,64,81,171,262,300,358],"evaluate":[29],"any":[30],"possible":[31],"connections":[32],"between":[33],"these":[34,104],"clinical":[38],"features.":[39],"METHODS:":[40],"144":[41],"SLE":[42,92,124,144,167,176,193,208,232,259,279,287,303,326,348,360],"patients,":[43],"27":[44],"non-SLE":[45,152],"rheumatisms":[48],"59":[50],"normal":[51,133,217,235,266,307],"controls":[52,134,218,236],"were":[53,61,126,146,169,194,237,260],"recruited":[54],"for":[55,100],"research,":[57],"all":[59,120,162,187,227],"subjects":[60],"drawn":[62],"isolate":[65],"plasma":[66],"elute":[68],"total":[69],"RNA.":[70],"SYBR":[71],"Green":[72],"Dye":[73],"based":[74],"real-time":[75],"quantitative":[76],"PCR":[77],"method":[78],"was":[79,112,210,281],"used":[80],"compare":[82],"4":[87,121,163,188,228],"IFNs":[88,122,164,189,229],"those":[94,130,149,172,263],"controls.":[97],"The":[98,158,223],"significance":[99,321,343],"correlation":[102],"disease":[108,327,349,361],"activity":[109],"specificity":[111],"studied.":[113],"RESULTS:":[114],"(1)":[115],"mRNA":[116],"remarkably":[127,211],"lower":[128,212],"than":[129,148,213,284,305],"observed":[131,150,173,215,264],"(P":[135,154,178,219,243,268,289],"<":[136,155,220,244,290],"0.01":[137,245],"all);":[139],"IFN-alpha":[140,276,331,355],"increased":[147],"group":[153,267,280,288,304],"0.01).":[156,221],"(2)":[157],"active":[166,278],"similar":[170,261],"inactive":[175,286],">":[179,269],"0.05":[180,270],"all),":[182,272],"not":[195],"correlated":[196,239],"involvements":[198],"kidney,":[200],"lung,":[201],"brain,":[202],"blood.":[203],"(3)":[204],"IFN":[205,339],"score":[206,340],"that":[214],"(4)":[222],"both":[231],"positively":[238],"each":[241],"other":[242],"all).":[247],"(5)":[248],"Protein":[249],"IFN-alpha,":[252,314],"IFN-beta":[253],"IFN-omega":[255],"protein":[273,293,352],"level":[274,294,337,353],"apparently":[282],"elevated":[283],"0.01),":[291],"IFN-gamma":[296],"has":[297,341],"a":[298],"trend":[299],"increase":[301],"group.":[308],"CONCLUSIONS:":[309],"Decreased":[310],"have":[319],"implicated":[320],"determination":[324,346],"specificity,":[328],"which":[330],"is":[332,356],"best.":[334],"Lower":[335],"also":[342],"specificity.":[350],"Higher":[351],"helpful":[357],"judging":[359],"activity.":[362]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
