{"id":"https://openalex.org/W2371973186","doi":null,"title":"Progress on Immunization with Amyloid-\u03b2 in a Mouse Model of Alzheimer's Disease","display_name":"Progress on Immunization with Amyloid-\u03b2 in a Mouse Model of Alzheimer's Disease","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2371973186","mag":"2371973186"},"language":"en","primary_location":{"id":"mag:2371973186","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-SHSW200106002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S62847986","display_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","issn_l":"1000-3282","issn":["1000-3282"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319982","host_organization_name":"Science Press","host_organization_lineage":["https://openalex.org/P4310319982"],"host_organization_lineage_names":["Science Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441650","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-5063-1551","observed_orcids":["https://orcid.org/0000-0002-5063-1551"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["2)  , HUA Qian    1)  , ZHANG Dai    2)**  , HE Rong  Qiao    1)**"],"raw_orcid":"https://orcid.org/0000-0002-5063-1551","affiliations":[{"raw_affiliation_string":"2)  , HUA Qian    1)  , ZHANG Dai    2)**  , HE Rong  Qiao    1)**","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100441650"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16071975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta-immunization","display_name":"amyloid-beta immunization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9279999732971191},{"id":"https://openalex.org/keywords/plaque-clearance","display_name":"plaque clearance","score":0.7409999966621399},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.777999997138977},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/passive-immunotherapy","display_name":"passive immunotherapy","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.6564524173736572},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5961650013923645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5895045399665833},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5755700469017029},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5321974158287048},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5267293453216553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4884265959262848},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4800351858139038},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4693364202976227},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.466158002614975},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4645661413669586},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4523211717605591},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4308534860610962},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.42934104800224304},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4285407066345215},{"id":"https://openalex.org/C2778943623","wikidata":"https://www.wikidata.org/wiki/Q3425478","display_name":"Active immunization","level":4,"score":0.42492809891700745},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3672693967819214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29194197058677673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11817529797554016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2371973186","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-SHSW200106002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S62847986","display_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","issn_l":"1000-3282","issn":["1000-3282"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319982","host_organization_name":"Science Press","host_organization_lineage":["https://openalex.org/P4310319982"],"host_organization_lineage_names":["Science Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2116031926","https://openalex.org/W2049703162","https://openalex.org/W1965275873","https://openalex.org/W2147014389","https://openalex.org/W2036001624","https://openalex.org/W2101174761","https://openalex.org/W1992741644","https://openalex.org/W2000917982","https://openalex.org/W7030597068","https://openalex.org/W1850100528"],"abstract_inverted_index":{"amyloid(A\u03b2)":[0],"is":[1],"a":[2,19],"predominant":[3],"component":[4],"of":[5,12,22,33,46,48,53,65,81],"senile":[6],"plaques,":[7],"one":[8],"central":[9,82],"pathological":[10],"hallmark":[11],"Alzheimer\ue10bs":[13],"disease.":[14],"Immunization":[15],"with":[16,43],"A\u03b2":[17,23,63],"causes":[18],"marked":[20],"reduction":[21],"burden":[24],"and":[25],"its":[26],"associated":[27],"pathologies":[28],"in":[29,40],"brain.":[30],"A":[31],"clearance":[32],"the":[34,73],"preexisting":[35],"plaques":[36],"has":[37,76],"been":[38],"observed":[39],"transgenic":[41],"mice,":[42],"an":[44,54],"inhibition":[45],"lesion":[47],"cognitive":[49],"functions.":[50],"No":[51],"signs":[52],"immune":[55],"mediated":[56],"response":[57,70],"could":[58],"be":[59],"detected":[60],"to":[61],"endogenous":[62],"peptide":[64],"mice.":[66],"The":[67],"chronic":[68],"inflammatory":[69],"resulted":[71],"from":[72],"immunization":[74],"itself":[75],"not":[77],"obviously":[78],"impaired":[79],"functions":[80],"nerve":[83],"system.":[84]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}