{"id":"https://openalex.org/W2371804841","doi":"https://doi.org/10.3760/cma.j.issn.1673-4386.2007.06.008","title":"Adeno-Associated Virus-Mediated Gene Transfer in Hematopoietic Stem/Progenitor Cells as a Therapeutic Tool","display_name":"Adeno-Associated Virus-Mediated Gene Transfer in Hematopoietic Stem/Progenitor Cells as a Therapeutic Tool","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2371804841","doi":"https://doi.org/10.3760/cma.j.issn.1673-4386.2007.06.008","mag":"2371804841"},"language":"en","primary_location":{"id":"mag:2371804841","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWYY200706009.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Genetics","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011321558","display_name":"Zhao Wei-hon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"\u6731\u84d3","raw_affiliation_strings":["210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80be\u5185\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80be\u5185\u79d1","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u8001\u5e74\u533b\u5b66\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u8001\u5e74\u533b\u5b66\u79d1","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"\u5434\u5251\u537f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5434\u5251\u537f","raw_affiliation_strings":["210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u8001\u5e74\u533b\u5b66\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u8001\u5e74\u533b\u5b66\u79d1","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"\u8d75\u536b\u7ea2","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"\u8d75\u536b\u7ea2","raw_affiliation_strings":["210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80be\u5185\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"210029,\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u80be\u5185\u79d1","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011321558"],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25400411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"06","first_page":"427","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ex-vivo-gene-transfer","display_name":"ex vivo gene transfer","score":0.8270000219345093},{"id":"https://openalex.org/keywords/viral-transduction","display_name":"viral transduction","score":0.6209999918937683},{"id":"https://openalex.org/keywords/autologous-transplantation","display_name":"autologous transplantation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7693602442741394},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7285435199737549},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.6903532147407532},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.6687461137771606},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6460921764373779},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6422155499458313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6366701722145081},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4790864586830139},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4702650010585785},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4560759365558624},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.42903637886047363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4048527479171753},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.398244172334671},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31418800354003906},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.2609640061855316},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.20917674899101257},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17657062411308289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17141646146774292},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.03578144311904907},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2371804841","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWYY200706009.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Genetics","raw_type":null},{"id":"mag:3029865325","doi":"https://doi.org/10.3760/cma.j.issn.1673-4386.2007.06.008","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN231536200706/352761.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306514250","display_name":"Int J Genet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Int J Genet","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3014371970","https://openalex.org/W2050316690","https://openalex.org/W2171052557","https://openalex.org/W6926877895","https://openalex.org/W2012134951","https://openalex.org/W7095266515","https://openalex.org/W4411462454","https://openalex.org/W2068392166","https://openalex.org/W2045343535","https://openalex.org/W1780966310"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1],"cells(HSCs)have":[2],"unique":[3],"properties":[4],"of":[5,57],"self-renewal,differentiation":[6],"and":[7,34],"proliferation.HSCs":[8],"can":[9],"be":[10],"readily":[11],"delivered":[12],"back":[13],"to":[14,46],"patients":[15],"by":[16,49],"autologous":[17],"transplantation,which":[18],"renders":[19],"them":[20],"as":[21],"attractive":[22],"targets":[23],"for":[24],"ex":[25],"vivo":[26],"gene":[27,39,60],"therapy.The":[28],"adeno-associated":[29],"virus(AAV)vectors":[30],"are":[31],"non-":[32],"pathogenic":[33],"have":[35],"applied":[36],"in":[37],"HSC":[38,47,59],"therapy.Although":[40],"conflicting":[41],"data":[42],"exist":[43],"with":[44],"regard":[45],"transduction":[48],"AAV":[50],"vectors,in":[51],"this":[52],"review,we":[53],"provide":[54],"an":[55],"overview":[56],"AAV-mediated":[58],"transfer.":[61]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
