{"id":"https://openalex.org/W2371680895","doi":null,"title":"Effect of captopril on bleomycin-induced pulmonary fibrosis in rats","display_name":"Effect of captopril on bleomycin-induced pulmonary fibrosis in rats","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2371680895","mag":"2371680895"},"language":"en","primary_location":{"id":"mag:2371680895","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZNYX201006020.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764436401","display_name":"Central South Pharmacy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Central South Pharmacy","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044687301","display_name":"Shikun Liu","orcid":"https://orcid.org/0000-0001-5942-0841","observed_orcids":["https://orcid.org/0000-0001-5942-0841"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shikun Liu","raw_affiliation_strings":["Department of Pharmacy,Third Xiangya Hospital,Central South University,Changsha 410205)"],"raw_orcid":"https://orcid.org/0000-0001-5942-0841","affiliations":[{"raw_affiliation_string":"Department of Pharmacy,Third Xiangya Hospital,Central South University,Changsha 410205)","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044687301"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37339056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.597000002861023},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.925000011920929},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-inhibition","display_name":"angiotensin-converting enzyme inhibition","score":0.7979999780654907},{"id":"https://openalex.org/keywords/alveolitis","display_name":"alveolitis","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.9692757725715637},{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.9399501085281372},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.8244870901107788},{"id":"https://openalex.org/C2908744134","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Lung fibrosis","level":4,"score":0.8050071001052856},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.755730152130127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6639770865440369},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5824140310287476},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.4653547406196594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41401731967926025},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39434581995010376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3472115397453308},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.16592937707901},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06025552749633789}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2371680895","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZNYX201006020.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764436401","display_name":"Central South Pharmacy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Central South Pharmacy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2390531891","https://openalex.org/W2365429543","https://openalex.org/W3032439039","https://openalex.org/W4232724037","https://openalex.org/W1768877551","https://openalex.org/W2462588650","https://openalex.org/W2393204821","https://openalex.org/W7072562409","https://openalex.org/W2384734421","https://openalex.org/W2746796546"],"abstract_inverted_index":{"Objective":[0],"To":[1],"determine":[2],"the":[3,12,17,47,75,81,88,104,107],"mechanism":[4,99],"of":[5,14,41,64,77,90,106],"lung":[6,18,51,62,68,78,82,91,94],"fibrosis":[7,69,95],"induced":[8,96],"by":[9,97],"bleomycin(BLM)":[10],"and":[11,35,53,67,80,93],"influence":[13],"captopril(CPT)":[15],"on":[16],"fibrosis.Methods":[19],"Sixty":[20],"SD":[21],"mice":[22,40],"were":[23,44,57],"divide":[24],"into":[25],"3":[26,42],"groups":[27,43],"randomly:":[28],"a":[29,36],"control":[30],"group,a":[31],"bleomycin":[32,60],"treated":[33,38],"group":[34],"combined(bleomycin+captopril)":[37],"group.The":[39],"executed":[45],"after":[46],"14":[48],"day":[49],"treatment.The":[50],"coefficient":[52],"pathologic":[54],"histology":[55],"states":[56],"recorded.Results":[58],"After":[59],"treatment,the":[61],"coefficient,degree":[63],"pulmonary":[65],"alveolitis":[66],"increased":[70],"significantly.Captopril":[71],"treatment":[72,85],"could":[73],"release":[74,87],"degree":[76,89],"damage":[79,92],"fibrosis.Conclusion":[83],"Captopril":[84],"can":[86],"BLM.The":[98],"may":[100],"be":[101],"related":[102],"to":[103],"suppression":[105],"angiotensin\u2161.":[108]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}