{"id":"https://openalex.org/W2371663256","doi":null,"title":"Expression of pleiotrophin in small cell lung cancer.","display_name":"Expression of pleiotrophin in small cell lung cancer.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2371663256","mag":"2371663256","pmid":"https://pubmed.ncbi.nlm.nih.gov/25864755"},"language":"en","primary_location":{"id":"pmid:25864755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25864755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Letter"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116517382","display_name":"Wang Hq","orcid":"https://orcid.org/0000-0002-2003-5230","observed_orcids":["https://orcid.org/0000-0002-2003-5230"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H Q Wang","raw_affiliation_strings":["Department of Respiratory Medicine, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011011039","display_name":"J Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Wang","raw_affiliation_strings":["Department of Respiratory Medicine, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"1","first_page":"175","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pleiotrophin","display_name":"pleiotrophin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6430000066757202},{"id":"https://openalex.org/keywords/heparin-binding-growth-factors","display_name":"heparin-binding growth factors","score":0.871999979019165},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tnm-staging","display_name":"TNM staging","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glandular-carcinoma","display_name":"glandular carcinoma","score":0.7179999947547913},{"id":"https://openalex.org/keywords/benign-pulmonary-lesions","display_name":"benign lung lesions","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2779822564","wikidata":"https://www.wikidata.org/wiki/Q14916160","display_name":"Pleiotrophin","level":4,"score":0.9202843904495239},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8816882371902466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5980029702186584},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5563061237335205},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5446568727493286},{"id":"https://openalex.org/C2909444961","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small Cell Lung Carcinoma","level":4,"score":0.4826936721801758},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4773309826850891},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4149520993232727},{"id":"https://openalex.org/C2779292878","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small-cell carcinoma","level":3,"score":0.40733110904693604},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.2358005940914154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20165851712226868},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25864755","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25864755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological regulators and homeostatic agents","raw_type":"Letter"},{"id":"mag:2371663256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25864755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2911195650","https://openalex.org/W2389992444","https://openalex.org/W2382737066","https://openalex.org/W3032779571","https://openalex.org/W2138142870","https://openalex.org/W2376305853","https://openalex.org/W2378021285","https://openalex.org/W2042944999","https://openalex.org/W2372107678","https://openalex.org/W2370983299"],"abstract_inverted_index":{"Pleiotrophin":[0],"(PTN)":[1],"is":[2,192],"a":[3,197],"kind":[4],"of":[5,22,25,59,74,104,205],"heparin":[6],"binding":[7],"growth":[8],"factor":[9],"closely":[10],"related":[11],"to":[12,18,178,195],"tumor":[13,169,199],"progression.":[14],"This":[15],"study":[16,45],"aimed":[17],"discuss":[19],"the":[20,23,68,72,100,109,118,128,138],"significance":[21],"expression":[24,58,95,107,126,152],"PTN":[26,60,94,106,125,151,175,191],"in":[27,99,108,117,127,137,154,160,182],"benign":[28,51,85],"and":[29,46,71,84,102,124,142,168,203],"malignant":[30],"lung":[31,37,47,77,82,110,157,183,188,206],"cancer":[32,40,78,83,111,131,144,158,189],"tissues,":[33],"especially":[34,185],"small":[35,75,129,186],"cell":[36,76,81,130,187],"cancer.":[38,207],"Lung":[39],"samples":[41,49],"were":[42,53,88,159],"collected":[43],"for":[44,201],"tissue":[48,64,87],"with":[50,67,79,156,163],"lesions":[52],"taken":[54],"as":[55],"controls.":[56],"The":[57],"was":[61,91,96,113,133,176],"detected":[62],"using":[63],"chip":[65],"combined":[66],"immunohistochemical":[69],"method,":[70],"differences":[73],"non-small":[80],"lesion":[86],"compared.":[89],"It":[90],"found":[92,177],"that":[93,116,136],"mainly":[97],"located":[98],"cytoplasm":[101],"membrane":[103],"cells;":[105],"group":[112,120,132,141,145],"higher":[114,134],"than":[115,135],"control":[119],"(p":[121,146,172],"<":[122,147,173],"0.01),":[123],"squamous":[139],"carcinoma":[140],"glandular":[143],"0.05).":[148,174],"In":[149],"addition,":[150],"quantity":[153],"patients":[155],"close":[161],"correlation":[162],"TNM":[164],"staging,":[165],"pathological":[166],"type":[167],"differentiation":[170],"degree":[171],"express":[179],"abnormally":[180],"high":[181],"cancer,":[184],"tissue.":[190],"most":[193],"likely":[194],"be":[196],"new":[198],"marker":[200],"diagnosis":[202],"prognosis":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}