{"id":"https://openalex.org/W2371625784","doi":null,"title":"Effect of hypoxia on E-Cadherin, Cytokeratin and Vimentin in breast cancer cell MCF7","display_name":"Effect of hypoxia on E-Cadherin, Cytokeratin and Vimentin in breast cancer cell MCF7","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2371625784","mag":"2371625784"},"language":"en","primary_location":{"id":"mag:2371625784","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SYYZ200610003.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764666221","display_name":"Shiyong yixue zazhi","issn_l":"1006-5725","issn":["1006-5725"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361729662","host_organization_name":"Medical Information of Guangdong Province","host_organization_lineage":["https://openalex.org/P4361729662"],"host_organization_lineage_names":["Medical Information of Guangdong Province"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shiyong yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048965048","display_name":"XU Duo-ron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"XU Duo-ron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048965048"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26137914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6000999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6000999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.20170000195503235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.12610000371932983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cytokeratin","display_name":"cytokeratin","score":0.972000002861023},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":1.0},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/matrigel-invasion-assay","display_name":"Matrigel invasion assay","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.9537395238876343},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.8707295656204224},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.8590154647827148},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5750339031219482},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4884285032749176},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4824393689632416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4624585807323456},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.44572460651397705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4313041567802429},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3921181261539459},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3683229386806488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2818434238433838},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2817748785018921},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27236634492874146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26866817474365234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07067564129829407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.044807106256484985},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2371625784","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SYYZ200610003.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764666221","display_name":"Shiyong yixue zazhi","issn_l":"1006-5725","issn":["1006-5725"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361729662","host_organization_name":"Medical Information of Guangdong Province","host_organization_lineage":["https://openalex.org/P4361729662"],"host_organization_lineage_names":["Medical Information of Guangdong Province"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shiyong yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2361768135","https://openalex.org/W2588791963","https://openalex.org/W992729757","https://openalex.org/W2080619157","https://openalex.org/W2385460105","https://openalex.org/W2030101893","https://openalex.org/W3092259584","https://openalex.org/W2369073897","https://openalex.org/W2379300407","https://openalex.org/W2767952473"],"abstract_inverted_index":{"Objective":[0],"To":[1],"study":[2,43],"the":[3,18,54,88,102,111],"effect":[4],"of":[5,57,94,105],"hypoxia":[6],"on":[7],"breast":[8,95],"cancer":[9,96],"cell":[10,45,97],"M":[11],"CF":[12],"7":[13],"invasion":[14,40,46],"through":[15,73],"Matrigel":[16,39],"and":[17,27,52,60,83,108],"underlying":[19],"molecular":[20],"mechanisms":[21],"by":[22,62],"regulatin":[23],"g":[24],"E-cadherin,":[25,106],"cytokeratin":[26,107],"vimentin":[28,84,109],"mRNA":[29,55,103],"level":[30,56],"in":[31,37,75],"vitro.":[32],"Methods":[33],"We":[34],"performe":[35],"d":[36],"vitro":[38],"assay":[41],"to":[42,71,101],"MCF7":[44,69,98],"under":[47,87,110],"an":[48],"imitated":[49],"hypoxic":[50,89,112],"condition":[51],"determined":[53],"E-Cadherin,":[58],"Cytokeratin":[59],"Vimentin":[61],"RT-PCR.":[63],"Results":[64],"Hypoxia":[65],"could":[66],"significantly":[67],"promote":[68],"cells":[70],"invade":[72],"Matrigel;":[74],"addition,":[76],"E-cadherin":[77],"was":[78,99],"down-regulated":[79],"while":[80],"cyto":[81],"keratin":[82],"were":[85],"up-regulated":[86],"condition.":[90,113],"Conclusion":[91],"The":[92],"aggressiveness":[93],"related":[100],"levels":[104]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}