{"id":"https://openalex.org/W2371522693","doi":null,"title":"After Transfer of the ras and Polyoma Middle T Oncogenes","display_name":"After Transfer of the ras and Polyoma Middle T Oncogenes","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2371522693","mag":"2371522693"},"language":"en","primary_location":{"id":"mag:2371522693","doi":null,"is_oa":false,"landing_page_url":"https://www.gastrojournal.org/article/0016-5085(93)91076-T/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074351912","display_name":"Eric Chastre","orcid":"https://orcid.org/0000-0002-8993-1228","observed_orcids":["https://orcid.org/0000-0002-8993-1228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Chastre","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8993-1228","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048622501","display_name":"Sylvie Empereur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvie Empereur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044324910","display_name":"Yolande Di Gioia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yolande Di Gioia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078892560","display_name":"Nour El Mahdani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nour El Mahdani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111926275","display_name":"Marc M. K. Mareel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Mareel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020876855","display_name":"Kris Vleminckx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kris Vleminckx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024953212","display_name":"Frans M. Van Roy","orcid":"https://orcid.org/0000-0003-4358-1039","observed_orcids":["https://orcid.org/0000-0003-4358-1039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frans van Roy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4358-1039","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110058144","display_name":"Val\u00e9rie Bex","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Bex","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111926446","display_name":"Shahin Emami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahin Emami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067050394","display_name":"Demetrios A. Spandidos","orcid":"https://orcid.org/0000-0002-1146-931X","observed_orcids":["https://orcid.org/0000-0002-1146-931X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Demetrios\ufffd\ufffd Spandidos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052850973","display_name":"Christian P. Gespach","orcid":"https://orcid.org/0000-0003-4397-1555","observed_orcids":["https://orcid.org/0000-0003-4397-1555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Gespach","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4397-1555","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ha-ras-oncogene","display_name":"Ha-ras oncogene","score":0.9150000214576721},{"id":"https://openalex.org/keywords/polyoma-middle-t-antigen","display_name":"PyMT","score":0.9079999923706055},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.722000002861023},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/type-iv-collagen","display_name":"type IV collagen","score":0.8230000138282776},{"id":"https://openalex.org/keywords/basement-membrane","display_name":"basement membrane","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/enterocyte-differentiation","display_name":"enterocyte differentiation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6992678642272949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6909644603729248},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6343904733657837},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5884767174720764},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5476949214935303},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4940703213214874},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44441360235214233},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4293305277824402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39646559953689575},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39442259073257446},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2862353026866913},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24560362100601196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1740398108959198},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.16810673475265503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12772110104560852}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2371522693","doi":null,"is_oa":false,"landing_page_url":"https://www.gastrojournal.org/article/0016-5085(93)91076-T/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W63256203","https://openalex.org/W88913772","https://openalex.org/W115891019","https://openalex.org/W165291943","https://openalex.org/W1481283361","https://openalex.org/W1492994972","https://openalex.org/W1494821536","https://openalex.org/W1525248227","https://openalex.org/W1540415460","https://openalex.org/W1546961183","https://openalex.org/W1597226951","https://openalex.org/W1598413822","https://openalex.org/W1615389580","https://openalex.org/W1627252162","https://openalex.org/W1809439466","https://openalex.org/W1837845068","https://openalex.org/W1862988248","https://openalex.org/W1869006121","https://openalex.org/W1926504087","https://openalex.org/W1950724735","https://openalex.org/W1969019995","https://openalex.org/W1973800266","https://openalex.org/W1975972551","https://openalex.org/W1980909969","https://openalex.org/W1984532705","https://openalex.org/W1996302235","https://openalex.org/W2001258296","https://openalex.org/W2005529016","https://openalex.org/W2021819656","https://openalex.org/W2022791326","https://openalex.org/W2032923234","https://openalex.org/W2039887030","https://openalex.org/W2044646351","https://openalex.org/W2046163031","https://openalex.org/W2048988574","https://openalex.org/W2052830851","https://openalex.org/W2058455228","https://openalex.org/W2060333964","https://openalex.org/W2061385217","https://openalex.org/W2066255481","https://openalex.org/W2068450419","https://openalex.org/W2069630989","https://openalex.org/W2071697240","https://openalex.org/W2073694135","https://openalex.org/W2074053722","https://openalex.org/W2075300416","https://openalex.org/W2076945917","https://openalex.org/W2083329677","https://openalex.org/W2091249772","https://openalex.org/W2091821685","https://openalex.org/W2111891248","https://openalex.org/W2121881330","https://openalex.org/W2128129514","https://openalex.org/W2128748400","https://openalex.org/W2139397808","https://openalex.org/W2142248554","https://openalex.org/W2159280116","https://openalex.org/W2167341007","https://openalex.org/W2206402902","https://openalex.org/W2395182040","https://openalex.org/W2418045011","https://openalex.org/W2433900206","https://openalex.org/W2443354603","https://openalex.org/W2444625880","https://openalex.org/W2462710599","https://openalex.org/W2513012500"],"related_works":["https://openalex.org/W2139070258","https://openalex.org/W91985027","https://openalex.org/W2091063983","https://openalex.org/W61269303","https://openalex.org/W2002083424","https://openalex.org/W2323259574","https://openalex.org/W2061538989","https://openalex.org/W2085224921","https://openalex.org/W2086177514","https://openalex.org/W62730437"],"abstract_inverted_index":{"Background:":[0],"Activation":[1],"of":[2,16,27,34,38,63,96,105,113,126,150,160,181,191,204,215],"the":[3,13,25,32,39,50,83,94,102,114,118,131,134,148,151,161,173,179,189,192,213],"~21\u201d":[4,193],"and":[5,36,49,73,85,92,99,128,141,194,207],"pp60c-src":[6],"oncoproteins":[7],"occurred":[8],"at":[9,201],"high":[10],"incidence":[11],"in":[12,31,42,166,208],"early":[14],"stage":[15],"human":[17,47,74],"colorectal":[18,205],"carcinogenesis.":[19],"Our":[20],"study":[21],"aimed":[22],"to":[23,172],"investigate":[24],"role":[26],"these":[28],"signal-transduction":[29],"pathways":[30,177,197],"process":[33],"initiation":[35],"promotion":[37],"malignant":[40],"phenotype":[41,116],"intestinal":[43,69],"cells.":[44,78],"Methods:":[45],"The":[46,158],"Ha-ras":[48,120],"polyoma":[51],"middle":[52],"T":[53,61],"(Py-MT)":[54],"viral":[55],"oncogenes":[56],"were":[57],"transferred":[58],"into":[59],"large":[60],"oncogene":[62,121],"simian":[64],"virus":[65],"40":[66],"immortalized":[67,89],"rat":[68],"epithelial":[70],"SLC-44":[71],"cells":[72,91,98,168,210],"colonic":[75],"adenocarcinoma":[76],"Caco-2":[77,97,209],"Results:":[79],"These":[80,185],"transfers":[81],"conferred":[82],"tumorigenic":[84],"invasive":[86,115],"phenotypes":[87],"on":[88],"SK-44":[90],"potentigted":[93],"tumorigenicity":[95],"markedly;":[100],"repressed":[101],"terminal":[103],"differentiation":[104],"this":[106],"cell":[107],"line.,":[108],"In":[109],"SK-44T":[110],"cells,":[111],"induction":[112],"by":[117],"activated":[119],"correlated":[122],"with":[123,212],"webk":[124],"expression":[125],"E-cadherin":[127],"reduced":[129],"accumulation~of":[130],"transcripts":[132],"encoding":[133],"basement":[135],"membrane\u2019":[136],"components":[137],"al(lV)":[138],"collagen,":[139],"nidogen,":[140],"BM40,":[142],"which":[143],"might":[144],"result":[145],"partly":[146],"from":[147],"inactivation":[149],"transforming":[152],"growth":[153],"factor":[154],"p":[155],"signaling":[156],"pathway.":[157],"down-regulation":[159],"ul(lV)":[162],"collagen":[163],"messenger":[164],"RNA":[165],"SLC-44T":[167],"was":[169],"not":[170],"due":[171],"protein":[174],"kinase":[175],"C-dependent":[176],"or":[178],"secretion":[180],"autocrine":[182],"factor(s).":[183],"Conclusions:":[184],"results":[186],"suggest":[187],"that":[188],"activation":[190],"Py-MT/pp60C-s\u201d":[195],"oncogenic":[196],"are":[198],"critical":[199],"effectors":[200],"different":[202],"stages":[203],"carcinogenesis":[206],"interferes":[211],"program":[214],"enterocyte":[216],"differentiation.":[217],"esearch":[218]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
