{"id":"https://openalex.org/W237149243","doi":null,"title":"ML238: An Antimalarial Small Molecule of a Unique Structural Class","display_name":"ML238: An Antimalarial Small Molecule of a Unique Structural Class","publication_year":2011,"publication_date":"2011-12-12","ids":{"openalex":"https://openalex.org/W237149243","mag":"237149243"},"language":"en","primary_location":{"id":"mag:237149243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23236647/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030497146","display_name":"Michel We\u00efwer","orcid":"https://orcid.org/0000-0002-4897-1450","observed_orcids":["https://orcid.org/0000-0002-4897-1450"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michel We\u00efwer","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0002-4897-1450","affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034685664","display_name":"Carol A. Mulrooney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Mulrooney","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013362774","display_name":"Daniela Massi","orcid":"https://orcid.org/0000-0002-5688-5923","observed_orcids":["https://orcid.org/0000-0002-5688-5923"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Massi","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0002-5688-5923","affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076516884","display_name":"Richard W. Heidebrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Heidebrecht","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079734650","display_name":"Roger C. Wiegand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger C. Wiegand","raw_affiliation_strings":["\u2021Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081926124","display_name":"Amanda K. Lukens","orcid":"https://orcid.org/0000-0002-9560-7643","observed_orcids":["https://orcid.org/0000-0002-9560-7643"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda K. Lukens","raw_affiliation_strings":["\u2021Harvard School of Public Health, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0002-9560-7643","affiliations":[{"raw_affiliation_string":"\u2021Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031269557","display_name":"Justin Dick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Dick","raw_affiliation_strings":["\u2021Harvard School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011964221","display_name":"Dyann F. Wirth","orcid":"https://orcid.org/0000-0002-8604-4455","observed_orcids":["https://orcid.org/0000-0002-8604-4455"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dyann F. Wirth","raw_affiliation_strings":["\u2021Harvard School of Public Health, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0002-8604-4455","affiliations":[{"raw_affiliation_string":"\u2021Harvard School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072154156","display_name":"Eric H. Ekland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric H. Ekland","raw_affiliation_strings":["Columbia University, Department of Microbiology and Immunology, New#N#York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, Department of Microbiology and Immunology, New#N#York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052786113","display_name":"Chih\u2010Chien Cheng","orcid":"https://orcid.org/0000-0003-1645-8457","observed_orcids":["https://orcid.org/0000-0003-1645-8457"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chih\u2010Chien Cheng","raw_affiliation_strings":["NIH Chemical Genomics Center, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0003-1645-8457","affiliations":[{"raw_affiliation_string":"NIH Chemical Genomics Center, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043714628","display_name":"Jean J. Zhao","orcid":"https://orcid.org/0000-0002-4561-5688","observed_orcids":["https://orcid.org/0000-0002-4561-5688"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean J. Zhao","raw_affiliation_strings":["NIH Chemical Genomics Center, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0002-4561-5688","affiliations":[{"raw_affiliation_string":"NIH Chemical Genomics Center, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043219268","display_name":"Jing Yuan","orcid":"https://orcid.org/0000-0002-8907-9143","observed_orcids":["https://orcid.org/0000-0002-8907-9143"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Yuan","raw_affiliation_strings":["National Institute of Allergy and Infectious Diseases, Bethesda,#N#MD"],"raw_orcid":"https://orcid.org/0000-0002-8907-9143","affiliations":[{"raw_affiliation_string":"National Institute of Allergy and Infectious Diseases, Bethesda,#N#MD","institution_ids":["https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075824166","display_name":"Xin\u2010zhuan Su","orcid":"https://orcid.org/0000-0003-3246-3248","observed_orcids":["https://orcid.org/0000-0003-3246-3248"]},"institutions":[{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin\u2010zhuan Su","raw_affiliation_strings":["National Institute of Allergy and Infectious Diseases, Bethesda,#N#MD"],"raw_orcid":"https://orcid.org/0000-0003-3246-3248","affiliations":[{"raw_affiliation_string":"National Institute of Allergy and Infectious Diseases, Bethesda,#N#MD","institution_ids":["https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049630472","display_name":"Ronald L. Johnson","orcid":"https://orcid.org/0000-0001-9693-9597","observed_orcids":["https://orcid.org/0000-0001-9693-9597"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald L. Johnson","raw_affiliation_strings":["NIH Chemical Genomics Center, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0001-9693-9597","affiliations":[{"raw_affiliation_string":"NIH Chemical Genomics Center, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069062997","display_name":"Rajarshi Guha","orcid":"https://orcid.org/0000-0001-7403-8819","observed_orcids":["https://orcid.org/0000-0001-7403-8819","https://orcid.org/0009-0004-4069-0111"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajarshi Guha","raw_affiliation_strings":["NIH Chemical Genomics Center, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0001-7403-8819","affiliations":[{"raw_affiliation_string":"NIH Chemical Genomics Center, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086104008","display_name":"Sivaraman Dandapani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sivaraman Dandapani","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113212935","display_name":"Benito Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benito Mu\u00f1oz","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112197978","display_name":"Michelle A. J. Palmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Palmer","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014278257","display_name":"Craig J. Thomas","orcid":"https://orcid.org/0000-0001-9386-9001","observed_orcids":["https://orcid.org/0000-0001-9386-9001"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig J. Thomas","raw_affiliation_strings":["NIH Chemical Genomics Center, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0001-9386-9001","affiliations":[{"raw_affiliation_string":"NIH Chemical Genomics Center, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044892430","display_name":"Christopher P. Austin","orcid":"https://orcid.org/0000-0001-7770-0708","observed_orcids":["https://orcid.org/0000-0001-7770-0708","https://orcid.org/0000-0002-6328-0156"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Austin","raw_affiliation_strings":["NIH Chemical Genomics Center, Bethesda, MD"],"raw_orcid":"https://orcid.org/0000-0001-7770-0708","affiliations":[{"raw_affiliation_string":"NIH Chemical Genomics Center, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071314941","display_name":"David Armand Fidock","orcid":"https://orcid.org/0000-0001-6753-8938","observed_orcids":["https://orcid.org/0000-0001-6753-8938"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Fidock","raw_affiliation_strings":["Columbia University, Department of Microbiology and Immunology, New#N#York, NY"],"raw_orcid":"https://orcid.org/0000-0001-6753-8938","affiliations":[{"raw_affiliation_string":"Columbia University, Department of Microbiology and Immunology, New#N#York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035618234","display_name":"Stuart L. Schreiber","orcid":"https://orcid.org/0000-0003-1922-7558","observed_orcids":["https://orcid.org/0000-0003-1922-7558"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart L. Schreiber","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA","Howard Hughes Medical Institute, Chemistry & Chemical Biology, Harvard University, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0003-1922-7558","affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chemistry & Chemical Biology, Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.8349999785423279},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.7120000123977661},{"id":"https://openalex.org/keywords/diversity-oriented-synthesis","display_name":"diversity-oriented synthesis","score":0.6489999890327454},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.550000011920929},{"id":"https://openalex.org/keywords/3d7-strain","display_name":"3D7 strain","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dd2-strain","display_name":"Dd2 strain","score":0.8899999856948853},{"id":"https://openalex.org/keywords/luciferase-reporter-assay","display_name":"luciferase reporter assay","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8946040868759155},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7488347291946411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6157166957855225},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.58111971616745},{"id":"https://openalex.org/C2908859342","wikidata":"https://www.wikidata.org/wiki/Q521616","display_name":"Antimalarial Agent","level":4,"score":0.4757382869720459},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4535346031188965},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.44678816199302673},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.41556206345558167},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3342551589012146},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32077622413635254},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23139655590057373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2095458209514618},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20748275518417358},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10117277503013611}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:237149243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23236647/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1993795323","https://openalex.org/W2006155895","https://openalex.org/W2007852671","https://openalex.org/W2010387696","https://openalex.org/W2014429457","https://openalex.org/W2038914330","https://openalex.org/W2045336630","https://openalex.org/W2048080607","https://openalex.org/W2067428749","https://openalex.org/W2071277359","https://openalex.org/W2076029682","https://openalex.org/W2087956351","https://openalex.org/W2106374535","https://openalex.org/W2128879247","https://openalex.org/W2128951621","https://openalex.org/W2132323730","https://openalex.org/W2132673947","https://openalex.org/W2152956231","https://openalex.org/W2318317030"],"related_works":["https://openalex.org/W7097649963","https://openalex.org/W2125661641","https://openalex.org/W2128988919","https://openalex.org/W2022515140","https://openalex.org/W2048080607","https://openalex.org/W3121860547","https://openalex.org/W4415955187","https://openalex.org/W147412700","https://openalex.org/W4401040645","https://openalex.org/W1993795323"],"abstract_inverted_index":{"Malaria,":[0],"the":[1,5,26,35,43,83,98,108,123,144,158,173,197,213],"most":[2,36],"devastating":[3],"of":[4,45,65,71,86,122,140,203],"parasitic":[6],"diseases,":[7],"afflicts":[8],"an":[9],"estimated":[10],"300-500":[11],"million":[12],"people":[13],"worldwide":[14],"and":[15,136,164],"results":[16],"in":[17,25,58,157,172,191,196,217],"more":[18],"than":[19],"800,000":[20],"deaths":[21],"annually.":[22],"Several":[23],"parasites":[24],"genus":[27],"Plasmodium":[28,32],"infect":[29],"humans,":[30],"but":[31],"falciparum":[33],"has":[34,41],"significant":[37],"lethality.":[38],"Drug":[39],"resistance":[40],"compromised":[42],"efficacy":[44],"existing":[46],"drugs.":[47],"New":[48],"antimalarial":[49,141,198],"agents,":[50],"especially":[51],"agents":[52],"that":[53],"work":[54],"against":[55,82,97,162],"new":[56,219,223],"targets":[57,220],"P.":[59,72,87,166],"falciparum,":[60,73],"are":[61],"needed.":[62],"As":[63],"part":[64],"efforts":[66],"to":[67,212],"identify":[68],"novel":[69,137,193],"inhibitors":[70],"we":[74,131],"initiated":[75],"a":[76,120,134,192],"quantitative":[77],"high-throughput":[78],"screening":[79],"(qHTS)":[80],"campaign":[81],"3D7":[84,163],"line":[85],"falciparum.":[88,167],"The":[89,151,188],"robust":[90],"whole":[91],"parasite":[92],"viability":[93],"assay":[94,161],"was":[95,170],"screened":[96],"Molecular":[99],"Libraries":[100],"Small":[101],"Molecule":[102],"Repository":[103],"(MLSMR)":[104],"as":[105,107],"well":[106],"Diversity-Oriented":[109],"Synthesis":[110],"(DOS)":[111],"informer":[112],"I":[113,149],"library":[114],"(approximately":[115],"8,000":[116],"compounds),":[117],"which":[118],"is":[119,190],"subset":[121],"Broad":[124,145],"Institute":[125,146],"DOS":[126,147],"library.":[127,150],"From":[128],"these":[129],"efforts,":[130],"have":[132],"identified":[133],"unique":[135],"structural":[138,194],"class":[139,195],"compounds":[142],"from":[143],"Informer":[148],"probe":[152,189,207],"(ML238)":[153],"displayed":[154],"picomolar":[155],"activity":[156,169],"SBYR":[159],"live/dead":[160],"Dd2":[165],"This":[168],"recapitulated":[171],"luciferase":[174],"assay,":[175],"albeit":[176],"at":[177],"single-digit":[178],"nanomolar":[179],"activity,":[180],"while":[181],"showing":[182],"no":[183],"apparent":[184],"mammalian":[185],"cell":[186],"cytotoxicity.":[187],"field":[199],"with":[200],"unknown":[201],"mechanism":[202],"action;":[204],"therefore,":[205],"this":[206],"will":[208],"be":[209],"highly":[210],"useful":[211],"malaria":[214],"research":[215],"community":[216],"identifying":[218],"or":[221],"developing":[222],"drug":[224],"classes.":[225]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}