{"id":"https://openalex.org/W2371347818","doi":null,"title":"The research progress on Telomere,Telomerase and hTERT/hTERC genes","display_name":"The research progress on Telomere,Telomerase and hTERT/hTERC genes","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2371347818","mag":"2371347818"},"language":"en","primary_location":{"id":"mag:2371347818","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YXYQ201204014.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764657723","display_name":"Journal of Molecular Diagnostics and Therapy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Diagnostics and Therapy","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009313040","display_name":"Baosheng Zhu","orcid":"https://orcid.org/0000-0002-5991-1752","observed_orcids":["https://orcid.org/0000-0002-5991-1752"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baosheng Zhu","raw_affiliation_strings":["Genetic Diagnosis Center,Kunhua Affiliated Hospital of Kunming Medical University,Yunnan,Kunming 650032,China)"],"raw_orcid":"https://orcid.org/0000-0002-5991-1752","affiliations":[{"raw_affiliation_string":"Genetic Diagnosis Center,Kunhua Affiliated Hospital of Kunming Medical University,Yunnan,Kunming 650032,China)","institution_ids":["https://openalex.org/I26080491"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009313040"],"corresponding_institution_ids":["https://openalex.org/I26080491"],"apc_list":null,"apc_paid":null,"fwci":0.214,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64485182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.9430000185966492},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hterc","display_name":"hTERC","score":0.9990000128746033},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.6800000071525574},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8759999871253967},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.7850000262260437},{"id":"https://openalex.org/keywords/telomerase-activation","display_name":"telomerase activation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6150000095367432},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.628000020980835},{"id":"https://openalex.org/keywords/telomeric-repeats","display_name":"telomeric repeats","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9834858179092407},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9392698407173157},{"id":"https://openalex.org/C34558173","wikidata":"https://www.wikidata.org/wiki/Q18031947","display_name":"Telomerase RNA component","level":5,"score":0.7041271328926086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6584706902503967},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.6403303742408752},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5882561206817627},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5296090841293335},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5004451274871826},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.44986841082572937},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.420979380607605},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.41916006803512573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37251701951026917},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34854745864868164},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34722450375556946},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.331256628036499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32242637872695923},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3029351532459259},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29831987619400024},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.1802186369895935}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2371347818","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YXYQ201204014.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764657723","display_name":"Journal of Molecular Diagnostics and Therapy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Diagnostics and Therapy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025637053","https://openalex.org/W2758902252","https://openalex.org/W2161969508","https://openalex.org/W2089030953","https://openalex.org/W2962043899","https://openalex.org/W2379337043","https://openalex.org/W2891111852","https://openalex.org/W3029740864","https://openalex.org/W2465907273","https://openalex.org/W2053873332"],"abstract_inverted_index":{"Telomere,the":[0],"DNA":[1],"sequences":[2],"at":[3],"the":[4,39,51,112,117],"end":[5],"of":[6,8,27,53,73,91,114,119],"chromosome":[7],"eukaryotic":[9],"cells,is":[10],"important":[11,84],"in":[12,18,42,78,86,126],"maintaining":[13],"genomic":[14,68,115],"stability.Telomeres":[15],"gradually":[16],"decrease":[17],"length":[19,60],"during":[20],"each":[21],"cell":[22,130],"division,owing":[23],"to":[24,35,50],"incomplete":[25],"replication":[26],"terminal":[28],"DNA.Telomeric":[29],"repeats":[30],"are":[31],"synthesized":[32],"by":[33],"telomerase":[34,54,74,92,99,108,127],"make":[36],"up":[37],"for":[38],"telomere":[40,57,59],"attrition":[41],"growing":[43],"rapidly":[44],"cells.Telomerase":[45],"gene":[46,75,93,109],"mutations":[47],"may":[48],"lead":[49],"reduction":[52],"activity":[55,100],"and":[56,95,129],"length.When":[58],"becomes":[61],"critically":[62],"short,it":[63],"can":[64],"no":[65],"longer":[66],"protect":[67],"stability,triggering":[69],"senescence,aging":[70],"or":[71],"carcinogenesis.Amplification":[72],"is":[76,101,111],"found":[77],"several":[79],"tumor":[80],"cells,which":[81],"plays":[82],"an":[83],"role":[85,125],"cancer":[87],"cells":[88],"proliferation.The":[89],"mechanism":[90],"amplification":[94,110],"its":[96],"regulation":[97],"on":[98],"still":[102],"currently":[103],"unknown.Recent":[104],"studies":[105],"show":[106],"that":[107],"consequence":[113],"instability,and":[116],"gain":[118],"hTERT":[120],"/hTERC":[121],"play":[122],"a":[123],"primitive":[124],"activation":[128],"immortalization.":[131]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}