{"id":"https://openalex.org/W2371264893","doi":null,"title":"[The clinical significance of vascular endothelial growth factor and intercellular adhesion molecule-1 expression in non-small cell lung cancer].","display_name":"[The clinical significance of vascular endothelial growth factor and intercellular adhesion molecule-1 expression in non-small cell lung cancer].","publication_year":2005,"publication_date":"2005-03-15","ids":{"openalex":"https://openalex.org/W2371264893","mag":"2371264893","pmid":"https://pubmed.ncbi.nlm.nih.gov/15854337"},"language":"zh","primary_location":{"id":"pmid:15854337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15854337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua wai ke za zhi [Chinese journal of surgery]","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100397224","display_name":"Hongwei Zhang","orcid":"https://orcid.org/0000-0001-6378-4883","observed_orcids":["https://orcid.org/0000-0001-6378-4883"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-wei Zhang","raw_affiliation_strings":["Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["250021,\u6d4e\u5357,\u5c71\u4e1c\u5927\u5b66\u5c71\u4e1c\u7701\u7acb\u533b\u9662\u80f8\u5916\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"250021,\u6d4e\u5357,\u5c71\u4e1c\u5927\u5b66\u5c71\u4e1c\u7701\u7acb\u533b\u9662\u80f8\u5916\u79d1","institution_ids":["https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing-han Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing-han Chen","raw_affiliation_strings":["ing-han,DU Jia-jun"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ing-han,DU Jia-jun","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103251874","display_name":"Jiajun Du","orcid":"https://orcid.org/0000-0001-7174-243X","observed_orcids":["https://orcid.org/0000-0001-7174-243X"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-jun Du","raw_affiliation_strings":["250021,\u6d4e\u5357,\u5c71\u4e1c\u5927\u5b66\u5c71\u4e1c\u7701\u7acb\u533b\u9662\u80f8\u5916\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"250021,\u6d4e\u5357,\u5c71\u4e1c\u5927\u5b66\u5c71\u4e1c\u7701\u7acb\u533b\u9662\u80f8\u5916\u79d1","institution_ids":["https://openalex.org/I4210116517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3765,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.5853198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"43","issue":"6","first_page":"354","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6298999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6298999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.33399999141693115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":1.0},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tnm-stage","display_name":"TNM stage","score":0.8600000143051147},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hematogenous-metastasis","display_name":"hematogenous metastasis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8489925861358643},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7205747365951538},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6298962235450745},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6048466563224792},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5610170364379883},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.530186116695404},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5085762739181519},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49024540185928345},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.4389268159866333},{"id":"https://openalex.org/C2909375385","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Intercellular Adhesion Molecule-1","level":3,"score":0.4271535277366638},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.41826456785202026},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3914027810096741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33817148208618164},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.2911074161529541},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1724332571029663},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1693936586380005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06743547320365906},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15854337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15854337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua wai ke za zhi [Chinese journal of surgery]","raw_type":"English Abstract"},{"id":"mag:2371264893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15854337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2389918531","https://openalex.org/W2372166685","https://openalex.org/W2361315636","https://openalex.org/W2357667609","https://openalex.org/W2369473900","https://openalex.org/W2412942344","https://openalex.org/W2380281023","https://openalex.org/W2360785033","https://openalex.org/W2368007286","https://openalex.org/W2388270983"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,22,71,99,104,118,157],"expression":[4,64,91,96,111],"of":[5,21,65,92,97,112,121,126,140,161],"vascular":[6],"endothelial":[7],"growth":[8],"factor":[9],"(VEGF)":[10],"and":[11,16,47,55,78,94,114,128,146,149,159],"intercellular":[12],"adhesion":[13],"molecule-1":[14],"(ICAM-1),":[15],"their":[17],"relationship":[18],"to":[19,44,136],"behaviors":[20],"non-small-cell":[23,33,122,131,162],"lung":[24,34,123,132,163],"cancer.":[25,35,124,164],"METHODS:":[26],"The":[27,62,110],"study":[28],"included":[29],"86":[30],"patients":[31,51,88],"with":[32,70,89,117],"A":[36],"rapid":[37],"immunohistochemical":[38],"method":[39],"(streptoavidin-peroxidase,":[40],"SP)":[41],"was":[42,67,85,103],"used":[43],"detect":[45],"VEGF":[46,66,93,113,127,148],"ICAM-1":[48,84,115,129,150],"expression.":[49],"All":[50],"were":[52],"treated":[53],"surgically":[54],"without":[56],"preoperative":[57],"radio-":[58],"or":[59],"chemotherapy.":[60],"RESULTS:":[61],"positive":[63,90],"significantly":[68],"correlated":[69],"lymph":[72,141],"node":[73,142],"metastasis,":[74,143],"TNM":[75,144],"stage,":[76],"prognosis":[77],"hematogenous":[79],"tumor":[80],"metastasis":[81,160],"positively,":[82],"but":[83],"negatively.":[86],"For":[87],"negative":[95],"ICAM-1,":[98],"5-year":[100],"survival":[101],"rate":[102],"lowest":[105],"in":[106,130,156],"all":[107],"patients.":[108],"CONCLUSIONS:":[109],"correlates":[116],"malignant":[119],"behavior":[120],"Examination":[125],"cancer":[133],"may":[134,151],"help":[135],"evaluate":[137],"its":[138],"intensity":[139],"stage":[145],"prognosis.":[147],"play":[152],"an":[153],"important":[154],"role":[155],"development":[158]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
