{"id":"https://openalex.org/W2371259720","doi":null,"title":"Damag to gut mucosal barrier and intestinal bacteria-endotoxin translocation in acute necrotizing pancreatitis rats","display_name":"Damag to gut mucosal barrier and intestinal bacteria-endotoxin translocation in acute necrotizing pancreatitis rats","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2371259720","mag":"2371259720"},"language":"en","primary_location":{"id":"mag:2371259720","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZPWZ200104011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764824895","display_name":"Zhonghua putong waike zazhi","issn_l":"1007-631X","issn":["1007-631X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua putong waike zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036113185","display_name":"Li Zhan","orcid":"https://orcid.org/0009-0004-4180-8206","observed_orcids":["https://orcid.org/0009-0004-4180-8206"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Li Zhan","raw_affiliation_strings":["liang, LU Lian  rong, LIANG Yan  jie, SUN Xiao  qing"],"raw_orcid":"https://orcid.org/0009-0004-4180-8206","affiliations":[{"raw_affiliation_string":"liang, LU Lian  rong, LIANG Yan  jie, SUN Xiao  qing","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036113185"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33457822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-necrotizing-pancreatitis","display_name":"acute necrotizing pancreatitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gut-mucosal-barrier","display_name":"gut mucosal barrier","score":0.8889999985694885},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.75},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8880000114440918},{"id":"https://openalex.org/keywords/d-lactate","display_name":"D-lactate","score":0.8920000195503235},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.6290000081062317},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.8460000157356262},{"id":"https://openalex.org/keywords/secondary-infection","display_name":"secondary infection","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6517605781555176},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.6348508596420288},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.6262645721435547},{"id":"https://openalex.org/C3018975166","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Bacterial translocation","level":4,"score":0.6006025075912476},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5707881450653076},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.5689465999603271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5623182654380798},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.5561015605926514},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.5527254939079285},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4697559177875519},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4638184905052185},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.431282639503479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22562584280967712},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07913362979888916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2371259720","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZPWZ200104011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764824895","display_name":"Zhonghua putong waike zazhi","issn_l":"1007-631X","issn":["1007-631X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua putong waike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2382833441","https://openalex.org/W2374276137","https://openalex.org/W2425494699","https://openalex.org/W3215373812","https://openalex.org/W2362561746","https://openalex.org/W3086485590","https://openalex.org/W2172475912","https://openalex.org/W2116521622","https://openalex.org/W2417934547","https://openalex.org/W2379923641"],"abstract_inverted_index":{"Objective":[0],"To":[1],"observe":[2],"the":[3,98,136,151,161],"changes":[4],"in":[5,13,135,143],"gut":[6,99,144],"mucosal":[7],"barrier":[8,130],"and":[9,33,51,55,72,93,112,141,157],"gut-origin":[10],"bacteria-endotoxin":[11,146],"translocation":[12,84,119],"acute":[14],"necrotizing":[15],"pancreatitis":[16],"(ANP)":[17],"rats.":[18],"Methods":[19],"Wistar":[20],"rats":[21],"were":[22,53,61,74,88,100],"divided":[23],"randomly":[24],"into":[25,45],"normal":[26],"group":[27,31,35],"(n=6),":[28],"sham":[29],"operation":[30],"(n=30)":[32],"ANP":[34,37,126],"(n=39).":[36],"was":[38,122],"introduced":[39],"by":[40,63],"infusion":[41],"of":[42,49,69,82,97,105,117,139,153,160],"artificial":[43],"bile":[44],"biliopancreatic":[46],"duct.":[47],"Morphology":[48],"pancreas":[50],"intestine":[52],"observed":[54],"tight":[56,94],"junction":[57,95],"on":[58],"ileum":[59],"epithelia":[60],"assessed":[62],"cryofracture":[64],"replicas":[65],"electroscopy.":[66],"Plasma":[67],"levels":[68,110],"D-lactic":[70],"acid":[71],"endotoxin":[73],"examined":[75],"at":[76],"various":[77],"time":[78],"points.":[79],"The":[80,115],"rates":[81],"bacterial":[83,118],"to":[85,120],"abdominal":[86],"organs":[87,121],"also":[89],"calculated.":[90],"Results":[91],"Mucosal":[92],"damages":[96],"found":[101],"during":[102],"early":[103,137],"stage":[104,138],"ANP.":[106],"Simultaneously,":[107],"plasma":[108],"D-lactate":[109],"increased":[111],"endotoxemia":[113],"occurred.":[114,127],"rate":[116],"59.5%":[123],"72h":[124],"after":[125],"Conclusions":[128],"Gut":[129],"function":[131],"can":[132],"be":[133,150],"injured":[134],"ANP,":[140],"resulting":[142],"origin":[145],"translocation,":[147],"which":[148],"may":[149],"originator":[152],"systemic":[154],"inflammatory":[155],"reaction":[156],"secondary":[158],"infection":[159],"pancreas.":[162]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}