{"id":"https://openalex.org/W23707885","doi":"https://doi.org/10.1182/blood.v25.4.457.457","title":"Interaction of Hemoglobin Lepore with Sickle Cell Trait and Microcythemia (Thalassemia) in a Southern Italian Family","display_name":"Interaction of Hemoglobin Lepore with Sickle Cell Trait and Microcythemia (Thalassemia) in a Southern Italian Family","publication_year":1965,"publication_date":"1965-04-01","ids":{"openalex":"https://openalex.org/W23707885","doi":"https://doi.org/10.1182/blood.v25.4.457.457","mag":"23707885","pmid":"https://pubmed.ncbi.nlm.nih.gov/14284335"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v25.4.457.457","doi":"https://doi.org/10.1182/blood.v25.4.457.457","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v25.4.457.457","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001188814","display_name":"Ezio Silvestroni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210143032","display_name":"St. Eugenio Hospital","ror":"https://ror.org/03h1gw307","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210143032"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"EZIO SILVESTRONI","raw_affiliation_strings":["Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d\u2019Igiene, Citta\u2019 Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy","Division of Hematology, St. Eugene Hospital, Rome; Director of Research Center for Microcythemias, Department of Hygiene, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d\u2019Igiene, Citta\u2019 Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]},{"raw_affiliation_string":"Division of Hematology, St. Eugene Hospital, Rome; Director of Research Center for Microcythemias, Department of Hygiene, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I4210143032","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036843652","display_name":"Ida Bianco","orcid":"https://orcid.org/0000-0002-5452-4702","observed_orcids":["https://orcid.org/0000-0002-5452-4702"]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"IDA BIANCO","raw_affiliation_strings":["Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d\u2019Igiene, Citta\u2019 Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy","Research Center for Microncythemiac, Department of Hygiene, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d\u2019Igiene, Citta\u2019 Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]},{"raw_affiliation_string":"Research Center for Microncythemiac, Department of Hygiene, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026911306","display_name":"Corrado Baglioni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"CORRADO BAGLIONI","raw_affiliation_strings":["Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d\u2019Igiene, Citta\u2019 Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy","International Laboratory of Genetics and Biophysics, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d\u2019Igiene, Citta\u2019 Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]},{"raw_affiliation_string":"International Laboratory of Genetics and Biophysics, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.395,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.59677419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"4","first_page":"457","last_page":"469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-lepore","display_name":"hemoglobin Lepore","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sickle-cell-trait","display_name":"sickle cell trait","score":0.9909999966621399},{"id":"https://openalex.org/keywords/thalassemia","display_name":"thalassemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hemoglobin-electrophoresis","display_name":"hemoglobin electrophoresis","score":0.722000002861023},{"id":"https://openalex.org/keywords/family-studies","display_name":"family studies","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.8120237588882446},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6790602207183838},{"id":"https://openalex.org/C2777566322","wikidata":"https://www.wikidata.org/wiki/Q3536635","display_name":"Sickle cell trait","level":3,"score":0.6567369103431702},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.4744499623775482},{"id":"https://openalex.org/C2777393523","wikidata":"https://www.wikidata.org/wiki/Q50008082","display_name":"Hemoglobin A","level":3,"score":0.46691444516181946},{"id":"https://openalex.org/C3020314195","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Hemoglobin s","level":4,"score":0.41978591680526733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3826729953289032},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36454224586486816},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.3332533538341522},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3182068169116974},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28731024265289307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28338557481765747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2632870674133301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2631392776966095},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.23414796590805054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16014760732650757}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001797","descriptor_name":"Blood Protein Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012805","descriptor_name":"Sickle Cell Trait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v25.4.457.457","doi":"https://doi.org/10.1182/blood.v25.4.457.457","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v25.4.457.457","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:14284335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14284335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.853.4921","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.853.4921","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bloodjournal.org/content/bloodjournal/25/4/457.full.pdf?sso-checked%3Dtrue","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W51588536","https://openalex.org/W229635216","https://openalex.org/W316274346","https://openalex.org/W2044272846","https://openalex.org/W2049891364","https://openalex.org/W2055927154","https://openalex.org/W2058772523","https://openalex.org/W2061360950","https://openalex.org/W2080929981","https://openalex.org/W2115250484","https://openalex.org/W2126665934","https://openalex.org/W2227912486","https://openalex.org/W2268201036","https://openalex.org/W2396084616","https://openalex.org/W2400531585","https://openalex.org/W2404368999","https://openalex.org/W2410956066","https://openalex.org/W2421575731","https://openalex.org/W2432865784"],"related_works":["https://openalex.org/W7099922798","https://openalex.org/W2082678163","https://openalex.org/W2461214769","https://openalex.org/W51588536","https://openalex.org/W2345624683","https://openalex.org/W1969248085","https://openalex.org/W2461644089","https://openalex.org/W2052726151","https://openalex.org/W2410210644","https://openalex.org/W2025968368"],"abstract_inverted_index":{"Abstract":[0],"An":[1],"abnormal":[2,31,54],"hemoglobin":[3,16,32,55],"has":[4,23,56,77],"been":[5,41,57,78],"observed":[6,79],"in":[7,80],"a":[8],"southern":[9],"Italian":[10],"family":[11],"together":[12],"with":[13,71],"sickle":[14,74],"cell":[15,75],"and":[17,49,59,73,87],"thalassemia":[18,72],"(microcythemia).":[19],"The":[20,35,53,66,85],"hematologic":[21,86],"study":[22],"shown":[24],"that":[25],"all":[26],"the":[27,30,91],"carriers":[28],"of":[29,37,68,82,90],"are":[33,95],"microcythemic.":[34],"hemoglobins":[36],"these":[38],"individuals":[39],"have":[40],"studied":[42],"by":[43,61],"paper,":[44],"starch":[45,47],"gel,":[46],"block":[48],"agar":[50],"gel":[51],"electrophoresis.":[52],"isolated":[58],"identified":[60],"fingerprinting":[62],"as":[63],"Hb":[64,69,92],"LeporeBoston.":[65],"combination":[67],"LeporeBoston":[70],"trait":[76],"members":[81],"this":[83],"family.":[84],"biochemical":[88],"implications":[89],"Lepore/thalassemia":[93],"disease":[94],"discussed.":[96]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
