{"id":"https://openalex.org/W2370770764","doi":null,"title":"SOCS3 and BCR-ABL fusion gene negative myeloproliferative diseases","display_name":"SOCS3 and BCR-ABL fusion gene negative myeloproliferative diseases","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2370770764","mag":"2370770764"},"language":"en","primary_location":{"id":"mag:2370770764","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-WYSB200802018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764353154","display_name":"International Journal of Pathology and Clinical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pathology and Clinical Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109297706","display_name":"Ling Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Pan","raw_affiliation_strings":["Department of Hemotology,Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemotology,Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)","institution_ids":["https://openalex.org/I4210099373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109297706"],"corresponding_institution_ids":["https://openalex.org/I4210099373"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27862776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.949999988079071},{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signaling","display_name":"suppressor of cytokine signaling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/negative-feedback-regulation","display_name":"negative feedback regulation","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.9477715492248535},{"id":"https://openalex.org/C14077384","wikidata":"https://www.wikidata.org/wiki/Q18033186","display_name":"Suppressor of cytokine signaling 1","level":4,"score":0.8977612257003784},{"id":"https://openalex.org/C84934515","wikidata":"https://www.wikidata.org/wiki/Q18033987","display_name":"SOCS6","level":4,"score":0.8274763822555542},{"id":"https://openalex.org/C106363011","wikidata":"https://www.wikidata.org/wiki/Q18034555","display_name":"SOCS5","level":5,"score":0.8044582605361938},{"id":"https://openalex.org/C162354598","wikidata":"https://www.wikidata.org/wiki/Q7644655","display_name":"Suppressor of cytokine signalling","level":5,"score":0.803241491317749},{"id":"https://openalex.org/C148968398","wikidata":"https://www.wikidata.org/wiki/Q18033469","display_name":"SOCS2","level":4,"score":0.61813884973526},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6162089109420776},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6095014214515686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5725799202919006},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.5468026399612427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5186671018600464},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4516066014766693},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.4504271447658539},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4437685012817383},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4259246587753296},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38415876030921936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36713534593582153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2786998152732849},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2564411759376526},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.23429647088050842},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.23369285464286804},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.1583191454410553},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2370770764","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-WYSB200802018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764353154","display_name":"International Journal of Pathology and Clinical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pathology and Clinical Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2955955410","https://openalex.org/W7039886552","https://openalex.org/W2049545543","https://openalex.org/W80075169","https://openalex.org/W2560694369","https://openalex.org/W1975088508","https://openalex.org/W2523503570","https://openalex.org/W2007809048","https://openalex.org/W7097584546","https://openalex.org/W1982078599"],"abstract_inverted_index":{"Several":[0],"cytokines":[1],"induce":[2],"the":[3,6,68],"expression":[4],"of":[5,8,20,27,41,58,73,79],"suppressor":[7,72],"cytokine":[9,21,28,74],"signaling(SOCS)gene":[10],"through":[11],"JAK/STAT":[12],"pathway,while":[13],"SOCS":[14],"protein":[15],"negatively":[16],"regulates":[17],"signal":[18,29],"transduction":[19,30],"pathway,and":[22],"a":[23],"negative":[24,37,69],"feedback":[25],"loop":[26],"is":[31,45,60],"thus":[32],"completed.In":[33],"BCR-ABL":[34],"fusion":[35],"gene":[36],"myeloproliferative":[38],"diseases,the":[39],"discovery":[40],"JAK2V617F":[42,52,64],"point":[43,53],"mutation":[44,54],"an":[46],"important":[47],"landmark.Recently,it":[48],"was":[49],"demonstrated":[50],"that":[51],"accompanied":[55],"with":[56],"highexpression":[57],"SOCS3.However,it":[59],"not":[61],"clear":[62],"why":[63],"mutant":[65],"could":[66],"escape":[67],"regulation":[70],"by":[71],"signaling":[75],"3":[76],"in":[77],"some":[78],"MPD":[80],"patients.":[81]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
