{"id":"https://openalex.org/W2370673045","doi":null,"title":"Changes in extracellular-signal regulated protein kinase expression between normal and apoptotic lens epithelial cells cultured","display_name":"Changes in extracellular-signal regulated protein kinase expression between normal and apoptotic lens epithelial cells cultured","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2370673045","mag":"2370673045"},"language":"en","primary_location":{"id":"mag:2370673045","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTotal-ZXDY200717025.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764930156","display_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","issn_l":"1005-8982","issn":["1005-8982"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727480","host_organization_name":"Danan University, Ministry of Health","host_organization_lineage":["https://openalex.org/P4361727480"],"host_organization_lineage_names":["Danan University, Ministry of Health"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040960637","display_name":"Songbai Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Songbai Jia","raw_affiliation_strings":["Xiangya Medical College,Central South University,Changsha,Hunan 410011,P"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xiangya Medical College,Central South University,Changsha,Hunan 410011,P","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040960637"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37467689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.46070000529289246,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.46070000529289246,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.30660000443458557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-signal-regulated-protein-kinase","display_name":"extracellular signal-regulated protein kinase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/uv-b-irradiation","display_name":"UVB irradiation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.9350000023841858},{"id":"https://openalex.org/keywords/posterior-capsule-opacification","display_name":"posterior capsule opacification","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8483709692955017},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7765403389930725},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6541664600372314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.590627908706665},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5749008059501648},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5728452801704407},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43808525800704956},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4304802715778351},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4250991642475128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35658755898475647},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33652204275131226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18540212512016296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11640620231628418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0532190203666687}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2370673045","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTotal-ZXDY200717025.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764930156","display_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","issn_l":"1005-8982","issn":["1005-8982"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727480","host_organization_name":"Danan University, Ministry of Health","host_organization_lineage":["https://openalex.org/P4361727480"],"host_organization_lineage_names":["Danan University, Ministry of Health"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2787909527","https://openalex.org/W2825240051","https://openalex.org/W1983908748","https://openalex.org/W2049620133","https://openalex.org/W1981768098","https://openalex.org/W3013231469","https://openalex.org/W3003833322","https://openalex.org/W1836235076","https://openalex.org/W3032592270","https://openalex.org/W2379247736"],"abstract_inverted_index":{"[Objective]":[0],"To":[1],"use":[2],"UVB-irridatiaon":[3,107],"to":[4,13,125],"cause":[5,109],"apoptosis":[6,110],"of":[7,53,55,67,73,75,81,92,111,116,118,128,132],"cultured":[8,48,112],"human":[9],"lens":[10],"epithelial":[11],"cells(LECs),and":[12],"observe":[14],"the":[15,42,57,68,76,79,84,88,90,95,103,114,119],"changes":[16],"in":[17,32,83,94,102,130],"extracellular-signal":[18],"regulated":[19],"protein":[20],"kinase(ERK)":[21],"expression":[22,52],"between":[23],"normal":[24],"and":[25,44,134],"apoptotic":[26],"LECs.[Methods]":[27],"Cultured":[28],"LECs":[29,120],"were":[30,37,47,87,98],"involved":[31],"this":[33],"study.The":[34],"test":[35,43,69,96],"groups":[36,46,58,86,97],"irridated":[38],"with":[39],"UVB.And":[40],"then":[41],"control":[45,77,104],"for":[49],"12":[50],"hours.The":[51],"ERK":[54,82,93,117,129],"all":[56],"was":[59,71],"detected":[60],"using":[61],"Western":[62],"Blot":[63],"method.[Results]":[64],"The":[65,106],"cells":[66],"group":[70],"half":[72],"that":[74,101],"group,but":[78],"expressions":[80,91,115],"two":[85],"same.Thus":[89],"more":[99],"than":[100],"groups.[Conclusion]":[105],"can":[108],"LECs,when":[113],"increase.This":[121],"study":[122],"is":[123],"useful":[124],"further":[126],"research":[127],"formation":[131],"cataract":[133],"posterior":[135],"capsular":[136],"opacification.":[137]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}