{"id":"https://openalex.org/W2369745748","doi":null,"title":"[Study of koumine-induced apoptosis of human colon adenocarcinoma LoVo cells in vitro].","display_name":"[Study of koumine-induced apoptosis of human colon adenocarcinoma LoVo cells in vitro].","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2369745748","mag":"2369745748","pmid":"https://pubmed.ncbi.nlm.nih.gov/13129717"},"language":"zh","primary_location":{"id":"pmid:13129717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13129717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066327801","display_name":"De-biao Chi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-biao Chi","raw_affiliation_strings":["Department of Pharmachology, First Military Medical University, Guangzhou 510515, China. chidb666@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmachology, First Military Medical University, Guangzhou 510515, China. chidb666@yahoo.com","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034662646","display_name":"Lin-sheng Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin-sheng Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081278308","display_name":"Hong Yan Jin","orcid":"https://orcid.org/0000-0002-8716-5179","observed_orcids":["https://orcid.org/0000-0002-8716-5179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072158745","display_name":"Jianxin Pang","orcid":"https://orcid.org/0000-0002-0053-2723","observed_orcids":["https://orcid.org/0000-0002-0053-2723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-xin Pang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101666692","display_name":"Yi-Ping Jiang","orcid":"https://orcid.org/0009-0006-5265-6863","observed_orcids":["https://orcid.org/0009-0006-5265-6863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-ping Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2124,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61362569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"23","issue":"9","first_page":"911","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/koumine","display_name":"koumine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/lovo-cells","display_name":"LoVo cells","score":1.0},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9769999980926514},{"id":"https://openalex.org/keywords/g0-g1-phase","display_name":"G0/G1 phase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.8600000143051147},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8220251202583313},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7216140627861023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6247926950454712},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6042304039001465},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5987565517425537},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5191354155540466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3626757562160492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2648753821849823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1502496600151062}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D031450","descriptor_name":"Gelsemium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:13129717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13129717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA","raw_type":"English Abstract"},{"id":"mag:2369745748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13129717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2363519203","https://openalex.org/W2033906892","https://openalex.org/W2350466793","https://openalex.org/W2087650597","https://openalex.org/W2392578159","https://openalex.org/W2392724788","https://openalex.org/W2376305895","https://openalex.org/W2355259601","https://openalex.org/W2378673761","https://openalex.org/W2378307004"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,24,41,62,89,115,123],"apoptosis-inducing":[4],"effect":[5],"of":[6,53,77,91,106],"koumine":[7,18],"on":[8],"human":[9],"colon":[10],"adenocarcinoma":[11],"LoVo":[12,25,78,107,119],"cells":[13,26,55,63,79,92,108],"in":[14,22,57,80,93,109,118],"vitro.":[15],"METHODS:":[16],"After":[17],"(50":[19],"mmol/L)":[20],"treatment":[21],"vitro,":[23],"were":[27,64],"examined":[28],"under":[29],"light":[30],"microscope,":[31],"transmission":[32],"electron":[33],"microscope":[34],"and":[35,40,88,113],"fluoroscope":[36],"respectively":[37],"for":[38],"apoptosis,":[39],"cell":[42,72,124],"cycle":[43,73,125],"distribution":[44],"was":[45],"analyzed":[46],"using":[47],"flow":[48],"cytometry.":[49],"RESULTS:":[50],"The":[51,75],"percentage":[52,76,90],"apoptotic":[54],"increased":[56],"a":[58,110],"time-dependent":[59,111],"manner":[60,112],"after":[61],"treated":[65],"with":[66],"koumine,":[67],"whose":[68],"action":[69],"exhibited":[70],"remarkable":[71],"specificity.":[74],"G(0)/G(1)":[81],"phase":[82,95],"rose":[83],"from":[84,97,126],"31.3%":[85],"to":[86,99,128],"42.3%":[87],"S":[94,129],"fells":[96],"62.0%":[98],"38.7%.":[100],"CONCLUSION:":[101],"Koumine":[102],"can":[103],"induce":[104],"apoptosis":[105],"inhibit":[114],"DNA":[116],"synthesis":[117],"cells,":[120],"thereby":[121],"blocking":[122],"G1":[127],"phase.":[130]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}