{"id":"https://openalex.org/W2369715615","doi":null,"title":"Elevated bioactive prolactin levels in systemic lupus erythematosus--association with disease activity.","display_name":"Elevated bioactive prolactin levels in systemic lupus erythematosus--association with disease activity.","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2369715615","mag":"2369715615","pmid":"https://pubmed.ncbi.nlm.nih.gov/11669159"},"language":"en","primary_location":{"id":"pmid:11669159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11669159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108228681","display_name":"Maria Pacilio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Pacilio","raw_affiliation_strings":["Department of Experimental Pharmacology, University of Naples, Federico II, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pharmacology, University of Naples, Federico II, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017328844","display_name":"Sergio Migliaresi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Migliaresi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033436256","display_name":"Rosaria Meli","orcid":"https://orcid.org/0000-0002-6246-6813","observed_orcids":["https://orcid.org/0000-0002-6246-6813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Meli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Ambrosone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Ambrosone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041597108","display_name":"B. Bigliardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Bigliardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111560418","display_name":"Raffaele Di Carlo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Di Carlo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5215,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.88376729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"10","first_page":"2216","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hyperprolactinemia","display_name":"hyperprolactinemia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sledai","display_name":"SLEDAI","score":0.8379999995231628},{"id":"https://openalex.org/keywords/malar-rash","display_name":"malar rash","score":0.7379999756813049},{"id":"https://openalex.org/keywords/central-nervous-system-manifestations","display_name":"central nervous system manifestations","score":0.9580000042915344},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.42800000309944153},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.3889999985694885},{"id":"https://openalex.org/keywords/immunoradiometric-assay","display_name":"immunoradiometric assay","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bioassay","display_name":"bioassay","score":0.6620000004768372},{"id":"https://openalex.org/keywords/central-nervous-system-autoimmunity","display_name":"central nervous system autoimmunity","score":0.6150000095367432},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2778758028","wikidata":"https://www.wikidata.org/wiki/Q19597582","display_name":"Immunoradiometric assay","level":3,"score":0.9119672179222107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.836025595664978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7585699558258057},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.643701434135437},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6080254912376404},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.539769172668457},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.527205765247345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5271693468093872},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5046993494033813},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3970698118209839},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3802003264427185},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.3693233132362366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3213318884372711},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.3175252676010132},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25780797004699707},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.23265406489372253}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006966","descriptor_name":"Hyperprolactinemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006966","descriptor_name":"Hyperprolactinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006966","descriptor_name":"Hyperprolactinemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015592","descriptor_name":"Immunoradiometric Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11669159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11669159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2369715615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11669159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W46654260","https://openalex.org/W57295588","https://openalex.org/W62137625","https://openalex.org/W130998881","https://openalex.org/W157397294","https://openalex.org/W326519981","https://openalex.org/W1566764007","https://openalex.org/W1892460249","https://openalex.org/W1967326156","https://openalex.org/W1968846455","https://openalex.org/W1976187110","https://openalex.org/W1979364006","https://openalex.org/W1980340355","https://openalex.org/W1986453241","https://openalex.org/W2017854040","https://openalex.org/W2017979753","https://openalex.org/W2031846165","https://openalex.org/W2037555316","https://openalex.org/W2040828615","https://openalex.org/W2056798857","https://openalex.org/W2064999867","https://openalex.org/W2066983662","https://openalex.org/W2070894640","https://openalex.org/W2074357767","https://openalex.org/W2085478602","https://openalex.org/W2113321984","https://openalex.org/W2119238166","https://openalex.org/W2123435698","https://openalex.org/W2126490595","https://openalex.org/W2131802077","https://openalex.org/W2132179144","https://openalex.org/W2141057965","https://openalex.org/W2145860954","https://openalex.org/W2146203649","https://openalex.org/W2276177824","https://openalex.org/W2398400962","https://openalex.org/W2400437304","https://openalex.org/W2406162057","https://openalex.org/W2407822394","https://openalex.org/W2413181817","https://openalex.org/W2417541072","https://openalex.org/W2419128767"],"related_works":["https://openalex.org/W2261900685","https://openalex.org/W1993416736","https://openalex.org/W1983637269","https://openalex.org/W7099996818","https://openalex.org/W1967326156","https://openalex.org/W3125642955","https://openalex.org/W2418959133","https://openalex.org/W1763712375","https://openalex.org/W2131802077","https://openalex.org/W2352254521"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,11,226,234,247,259,301],"possibility":[4],"that":[5,76,294],"prolactin":[6],"(PRL)":[7],"is":[8],"involved":[9],"in":[10,24,89,96,123,128,175,182,233,240,258,276,300],"pathogenesis":[12,302],"of":[13,236,250,303],"systemic":[14],"lupus":[15],"erythematosus":[16],"(SLE).":[17],"METHODS:":[18],"We":[19],"determined":[20,66],"serum":[21,26,215],"PRL":[22,63,108,136,194,295],"levels":[23,109,137,195],"122":[25],"samples":[27,216],"from":[28,217,246],"78":[29],"unselected":[30],"patients":[31,91,125,177,219,260,277],"with":[32,132,172,193,261,278,288],"SLE":[33,120,279],"(73":[34],"women,":[35],"5":[36],"men,":[37],"age":[38],"range":[39,145,150,159,164],"16-71":[40],"yrs).":[41],"Disease":[42,58],"activity":[43],"was":[44,87,110,121,170,230,273,286],"defined":[45],"according":[46],"to":[47,118],"Lupus":[48,57],"Activity":[49,59],"Criteria":[50],"Count":[51],"(LACC)":[52],"and":[53,71,95,106,126,155,181,204,242,253,266,282,285],"scored":[54],"by":[55,67,72,93,99,141,179,185,197,280,283],"Systemic":[56],"Index":[60],"(SLEDAI).":[61],"Serum":[62],"concentrations":[64],"were":[65,138],"immunoradiometric":[68],"assay":[69,74],"(IRMA)":[70],"biological":[73],"(BA)":[75],"evaluates":[77],"Nb2":[78],"lymphoma":[79],"cell":[80],"proliferation.":[81],"RESULTS:":[82],"Hyperprolactinemia":[83,169,272],"(>":[84],"20":[85],"ng/ml)":[86],"found":[88,111],"21":[90],"(26.9%)":[92],"IRMA":[94,105,142,180,198,281],"31":[97],"(39.7%)":[98],"BA.":[100],"A":[101,211],"significant":[102],"correlation":[103],"between":[104],"BA":[107,156,186,205,284],"(rs":[112,199,206],"0.46,":[113],"p":[114,152,166,201,208,267],"<":[115,153,167,188,202,209,264,268],"0.001).":[116,168],"According":[117],"LACC,":[119],"active":[122,133,173],"29":[124],"inactive":[127],"49.":[129],"In":[130],"those":[131],"disease":[134,174,289],"median":[135],"higher":[139],"both":[140,196],"(18.5":[143],"ng/ml,":[144,149,158,163],"2.2-51.2":[146],"vs":[147,161],"10.6":[148],"3.9-29.6;":[151],"0.001)":[154,203],"(21.0":[157],"12.4-84":[160],"14.9":[162],"4.2-46.1;":[165],"associated":[171,287],"13/21":[176],"(61.9%)":[178],"18/31":[183],"(58.1%)":[184],"(p":[187,263],"0.01).":[189],"SLEDAI":[190],"scores":[191],"correlated":[192],"0.5,":[200],"0.41,":[207],"0.02).":[210],"followup":[212],"analysis":[213],"on":[214],"44":[218],"seen":[220],"again":[221],"after":[222],"6-8":[223],"mo":[224],"confirmed":[225],"above":[227],"results.":[228],"There":[229],"no":[231],"difference":[232],"rate":[235],"different":[237],"clinical":[238],"manifestations":[239,257],"hyperprolactinemic":[241],"normoprolactinemic":[243],"subjects,":[244],"apart":[245],"increased":[248],"prevalence":[249],"malar":[251],"rash":[252],"central":[254],"nervous":[255],"system":[256],"hyperprolactinemia":[262],"0.03":[265],"0.01,":[269],"respectively).":[270],"CONCLUSION:":[271],"frequently":[274],"detected":[275],"activity.":[290],"Our":[291],"findings":[292],"suggest":[293],"may":[296],"play":[297],"a":[298],"role":[299],"SLE.":[304]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
