{"id":"https://openalex.org/W2369712432","doi":null,"title":"Research of combination therapy with Huangqi and Shanyao on MLP-STZ induced diabetic mice","display_name":"Research of combination therapy with Huangqi and Shanyao on MLP-STZ induced diabetic mice","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2369712432","mag":"2369712432"},"language":"en","primary_location":{"id":"mag:2369712432","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JJXZ201205002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764376178","display_name":"Journal of Regional Anatomy and Operative Surgery","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4362726039","host_organization_name":"Chongqing Anatomy Society","host_organization_lineage":["https://openalex.org/P4362726039"],"host_organization_lineage_names":["Chongqing Anatomy Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Regional Anatomy and Operative Surgery","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042173493","display_name":"Hao Yun-fei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Yun-fei","raw_affiliation_strings":["Institute of Geratology,General Hospital of PLA,Beijing 100853,China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Geratology,General Hospital of PLA,Beijing 100853,China)","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042173493"],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.33008672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.10379999876022339,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astragalus-membranaceus","display_name":"Astragalus membranaceus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dioscorea-opposita","display_name":"Dioscorea opposita","score":0.5239999890327454},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7129999995231628},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.875},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6169999837875366},{"id":"https://openalex.org/keywords/th1-th2-cytokines","display_name":"Th1/Th2 cytokines","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/splenocyte-proliferation","display_name":"splenocyte proliferation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8419582843780518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8212287425994873},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6727051734924316},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6075901985168457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5988799929618835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5820157527923584},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5790280699729919},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.5647345781326294},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5408942699432373},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.5071859359741211},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.49788379669189453},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47958603501319885},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.46900674700737},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.42816102504730225},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4184481203556061},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3430629074573517},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2014058232307434},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12468856573104858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09400635957717896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09200096130371094},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2369712432","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JJXZ201205002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764376178","display_name":"Journal of Regional Anatomy and Operative Surgery","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4362726039","host_organization_name":"Chongqing Anatomy Society","host_organization_lineage":["https://openalex.org/P4362726039"],"host_organization_lineage_names":["Chongqing Anatomy Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Regional Anatomy and Operative Surgery","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2938507477","https://openalex.org/W1565139018","https://openalex.org/W2393762078","https://openalex.org/W4282839641","https://openalex.org/W2045906440","https://openalex.org/W1974350758","https://openalex.org/W3007742776","https://openalex.org/W4386212100","https://openalex.org/W2376432631","https://openalex.org/W2371866470"],"abstract_inverted_index":{"Objective":[0],"To":[1],"study":[2],"the":[3,80,110,142,168,199],"effects":[4,226],"of":[5,27,44,88,103,109,115,127,145,171,202],"combination":[6,165,187,196,218],"therapy":[7],"with":[8,57,141],"Huangqi":[9,56,162,193,215],"and":[10,75,92,100,148,163,167,186,195,216,227],"Shanyao":[11,164,184,217],"on":[12],"MLP-STZ(multiple":[13],"low":[14,29],"dose":[15,30],"streptozotocin":[16],"MLD-STZ)induced":[17],"diabetic":[18,32,81,222],"mice.Methods":[19],"Mouse":[20],"model":[21,143],"was":[22,41,120],"established":[23],"by":[24,98,122,131,135,161],"intraperitoneal":[25],"injection":[26],"multiple":[28],"streptozotocin(MLD-STZ).The":[31],"mice":[33,82,111],"were":[34,83,96,112,133,159,174],"divided":[35],"into":[36],"4":[37,86],"groups,and":[38],"each":[39],"group":[40,173,185,188,194,197],"intragastric":[42],"administered":[43],"Shanyao(1.4":[45],"g":[46,51,59,66],"\u00b7":[47,49,52,54,60,62,67,69],"kg-1":[48,53,61,68],"d-1),Huangqi(2.8":[50],"d-1),compatible":[55],"Shanyao(4.2":[58],"d-1)and":[63],"distilled":[64],"water(4.2":[65],"d-1)every":[70],"day":[71],"respectively.Detected":[72],"glucose":[73,146],"level":[74,147],"body":[76,149],"weight":[77,150],"every":[78],"week,then":[79],"killed":[84],"after":[85],"weeks":[87],"treatment.Pancreatic":[89],"histological":[90],"analysis":[91],"islet":[93,157],"cell":[94],"apoptosis":[95,169],"measured":[97,134],"HE":[99],"TUNEL":[101],"labeling.Activities":[102],"superoxide":[104],"dismutase(SOD)and":[105],"nitric":[106],"oxide(NO)in":[107],"serum":[108,190],"detected.Proliferation":[113],"ability":[114,201],"splenocytes":[116,132,203],"to":[117,204],"concanavalin":[118,205],"A":[119],"tested":[121],"using":[123],"MTT":[124],"assay.The":[125],"levels":[126],"cytokine":[128,209],"interferon-\u03b3(IFN-\u03b3)and":[129],"interleukin-4(IL-4)secreted":[130],"enzyme":[136],"linked":[137],"immunosorbent":[138],"assay(ELISA).Results":[139],"Compared":[140],"group,down-regulation":[144],"occurred":[151],"in":[152],"all":[153],"medicine":[154,177],"treatment":[155,166,178],"groups.The":[156],"cells":[158],"protected":[160],"ratio":[170],"this":[172],"significantly":[175],"decreased.All":[176],"groups":[179],"could":[180,219],"inhibit":[181],"NO":[182],"production.The":[183],"up-regulatd":[189],"SOD":[191],"significantly.The":[192],"decreased":[198],"proliferation":[200],"A,and":[206],"down-regulated":[207],"Th1/Th2":[208],"ratio.Conclusion":[210],"The":[211],"results":[212],"showed":[213],"that":[214],"effectively":[220],"prevent":[221],"mouse":[223],"via":[224],"immunotherapeutic":[225],"antioxidative":[228],"effect.":[229]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
