{"id":"https://openalex.org/W23696427","doi":null,"title":"KRN7000, a novel immunomodulator, and its antitumor activities.","display_name":"KRN7000, a novel immunomodulator, and its antitumor activities.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W23696427","mag":"23696427","pmid":"https://pubmed.ncbi.nlm.nih.gov/8866665"},"language":"en","primary_location":{"id":"pmid:8866665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8866665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"E Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802592688","display_name":"Kirin (Japan)","ror":"https://ror.org/0586k5242","country_code":"JP","type":"company","lineage":["https://openalex.org/I2802592688"]},{"id":"https://openalex.org/I4405274001","display_name":"Kirin Brewery Company, Limited (Japan)","ror":"https://ror.org/00vm6vn72","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274001"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E Kobayashi","raw_affiliation_strings":["Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan","institution_ids":["https://openalex.org/I2802592688","https://openalex.org/I4405274001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110457065","display_name":"Kazuhiro Motoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Motoki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047434676","display_name":"Takeshi Uchida","orcid":"https://orcid.org/0000-0001-9270-8329","observed_orcids":["https://orcid.org/0000-0001-9270-8329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Uchida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042244557","display_name":"Hidehiko Fukushima","orcid":"https://orcid.org/0000-0002-2879-4370","observed_orcids":["https://orcid.org/0000-0002-2879-4370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Fukushima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111906226","display_name":"Yasuhiko Koezuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Koezuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7946,"has_fulltext":false,"cited_by_count":360,"citation_normalized_percentile":{"value":0.69369852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"7","issue":"10-11","first_page":"529","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-galactosylceramide","display_name":"alpha-galactosylceramide","score":1.0},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.9549999833106995},{"id":"https://openalex.org/keywords/biological-response-modifiers","display_name":"biological response modifiers","score":0.902999997138977},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8130000233650208},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/el4-lymphoma","display_name":"EL4 lymphoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/prolonged-survival","display_name":"survival prolongation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.609000027179718},{"id":"https://openalex.org/keywords/mixed-lymphocyte-reaction","display_name":"mixed lymphocyte reaction","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6995733976364136},{"id":"https://openalex.org/C2780108502","wikidata":"https://www.wikidata.org/wiki/Q4915018","display_name":"Biological response modifiers","level":3,"score":0.6486515402793884},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.50532466173172},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5046766996383667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47161298990249634},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4438294768333435},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44356605410575867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38354480266571045},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15664350986480713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15313613414764404},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005699","descriptor_name":"Galactosylceramides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010844","descriptor_name":"Picibanil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8866665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8866665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology research","raw_type":"Comparative Study"},{"id":"mag:23696427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8866665","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W40876227","https://openalex.org/W1980464564","https://openalex.org/W1982571807","https://openalex.org/W1983890855","https://openalex.org/W2002877359","https://openalex.org/W2010873791","https://openalex.org/W2011500872","https://openalex.org/W2011691055","https://openalex.org/W2013017376","https://openalex.org/W2016510337","https://openalex.org/W2020999238","https://openalex.org/W2044428513","https://openalex.org/W2046318721","https://openalex.org/W2055913843","https://openalex.org/W2062514677","https://openalex.org/W2064910014","https://openalex.org/W2064973787","https://openalex.org/W2068710494","https://openalex.org/W2087393332","https://openalex.org/W2093982682","https://openalex.org/W2103791867","https://openalex.org/W2115779644","https://openalex.org/W2123198963","https://openalex.org/W2136662654","https://openalex.org/W2143170158","https://openalex.org/W2144494899","https://openalex.org/W2159122273","https://openalex.org/W2162577559","https://openalex.org/W2168781691","https://openalex.org/W2169828275","https://openalex.org/W4250024569","https://openalex.org/W4255396331","https://openalex.org/W7074234824"],"related_works":["https://openalex.org/W2116556475","https://openalex.org/W2470177655","https://openalex.org/W2417479087","https://openalex.org/W960091457","https://openalex.org/W3019991348","https://openalex.org/W1979508241","https://openalex.org/W1965707614","https://openalex.org/W2013687299","https://openalex.org/W2059993578","https://openalex.org/W1976629717"],"abstract_inverted_index":{"KRN7000,":[0],"a":[1,4,31,86,162,176],"compound":[2],"with":[3,103,130,137],"novel":[5],"alpha-galactosylceramide":[6],"structure,":[7],"showed":[8,106],"potent":[9,107],"tumor":[10],"growth":[11],"inhibitory":[12],"activities":[13,109],"in":[14,22,47,50,61,64,72,166],"B16-bearing":[15],"mice":[16,127,134],"and":[17,49,56,63,68,94,112,152],"markedly":[18],"stimulated":[19],"lymphocytic":[20],"proliferation":[21],"allogeneic":[23],"mixed":[24],"leukocyte":[25],"reaction,":[26],"suggesting":[27],"that":[28,58,158,172],"KRN7000":[29,44,59,104,120,143,173],"is":[30,85],"biological":[32],"response":[33],"modifier.":[34],"To":[35],"confirm":[36],"this":[37],"suggestion,":[38],"we":[39,115],"examined":[40],"the":[41,90,117,123,148],"abilities":[42],"of":[43,81,119,126,150,159],"to":[45,121],"enhance":[46],"vitro":[48,62],"vivo":[51,65,73],"natural":[52],"killer":[53],"(NK)":[54],"activities,":[55,67],"found":[57],"enhanced":[60],"NK":[66,74],"its":[69,153],"potency":[70,154],"on":[71],"activity":[75],"was":[76,155],"much":[77],"stronger":[78,156],"than":[79,157],"those":[80],"Poly":[82],"I:C,":[83],"which":[84],"positive":[87],"control,":[88],"or":[89,133],"representative":[91],"BRMs":[92],"OK432":[93],"Lentinan.":[95],"In":[96,140],"addition,":[97],"since":[98],"spleen":[99],"cells":[100,132],"intravenously":[101,128],"treated":[102],"also":[105],"cytotoxic":[108],"against":[110],"B16":[111,131],"EL-4":[113,138],"cells,":[114],"evaluated":[116],"capability":[118],"prolong":[122],"survival":[124],"period":[125],"inoculated":[129,136],"intraperitoneally":[135],"cells.":[139],"these":[141],"models,":[142],"(100":[144],"micrograms/kg)":[145],"significantly":[146],"prolonged":[147],"lifespan":[149],"mice,":[151],"Mitomycin":[160],"C,":[161],"typical":[163],"chemotherapeutic":[164],"agent,":[165],"two":[167],"models.":[168],"These":[169],"results":[170],"demonstrate":[171],"would":[174],"be":[175],"useful":[177],"agent":[178],"for":[179],"cancer":[180],"therapy.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
