{"id":"https://openalex.org/W236949580","doi":null,"title":"Effects of thrombolytic drugs and a selective endothelin-1 receptor antagonist on acute pulmonary thromboembolism in dogs.","display_name":"Effects of thrombolytic drugs and a selective endothelin-1 receptor antagonist on acute pulmonary thromboembolism in dogs.","publication_year":2010,"publication_date":"2010-02-20","ids":{"openalex":"https://openalex.org/W236949580","mag":"236949580","pmid":"https://pubmed.ncbi.nlm.nih.gov/20193475"},"language":"en","primary_location":{"id":"pmid:20193475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20193475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101436737","display_name":"Li Han","orcid":"https://orcid.org/0000-0003-0468-9012","observed_orcids":["https://orcid.org/0000-0003-0468-9012"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Han","raw_affiliation_strings":["Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685482","display_name":"Qingyun Li","orcid":"https://orcid.org/0000-0001-8128-6319","observed_orcids":["https://orcid.org/0000-0001-8128-6319","https://orcid.org/0000-0002-5809-712X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-yun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101850485","display_name":"Zhou Ling","orcid":"https://orcid.org/0000-0001-8518-1733","observed_orcids":["https://orcid.org/0000-0001-8518-1733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026739","display_name":"Xi Wang","orcid":"https://orcid.org/0000-0002-5974-6363","observed_orcids":["https://orcid.org/0000-0002-5974-6363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029499058","display_name":"Zhiyao Bao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-yao Bao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400752","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-7113-2700","observed_orcids":["https://orcid.org/0000-0002-7113-2700","https://orcid.org/0000-0002-5551-0134","https://orcid.org/0009-0008-7671-1462","https://orcid.org/0000-0001-7093-4931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054265503","display_name":"Huan-Ying Wan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huan-ying Wan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111026105","display_name":"Guochao Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo-chao Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5352,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7368857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"123","issue":"4","first_page":"395","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-pulmonary-embolism","display_name":"acute pulmonary embolism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bq-123","display_name":"BQ-123","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endothelin-1-receptor-antagonists","display_name":"endothelin-1 receptor antagonists","score":0.9769999980926514},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mean-pulmonary-artery-pressure","display_name":"mean pulmonary artery pressure","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neurohumoral-factors","display_name":"neurohumoral factors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.7279999852180481},{"id":"https://openalex.org/keywords/autologous-blood-clot","display_name":"autologous blood clot","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.777999997138977},{"id":"https://openalex.org/keywords/pulmonary-vasodilation","display_name":"pulmonary vasodilation","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8919329047203064},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5811774730682373},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.5532641410827637},{"id":"https://openalex.org/C2777377995","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolytic drug","level":4,"score":0.5287294387817383},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.5178325772285461},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.4893142879009247},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.46428146958351135},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.4618391692638397},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.43401941657066345},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4330950081348419},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4103602468967438},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33996713161468506},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.266306608915329},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2298409640789032},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.20299962162971497}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011655","descriptor_name":"Pulmonary Embolism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013931","descriptor_name":"Thromboxanes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D065130","descriptor_name":"Endothelin A Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:20193475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20193475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:236949580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20193475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2381555731","https://openalex.org/W2340522855","https://openalex.org/W2379665163","https://openalex.org/W2158611607","https://openalex.org/W2378475192","https://openalex.org/W3029467819","https://openalex.org/W258107199","https://openalex.org/W2138448233","https://openalex.org/W2899375327","https://openalex.org/W2356542884"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"has":[2],"been":[3],"shown":[4],"that":[5,287],"neurohumoral":[6],"factors":[7],"other":[8,84],"than":[9,242,272],"mechanical":[10],"obstruction":[11],"are":[12],"involved":[13],"in":[14,47,72,82,95,116,158,167,194,212,222,244,268,273,334],"the":[15,30,73,83,96,117,146,162,168,173,195,213,223,245,269,274,288,296,307,313,327],"pathophysiology":[16],"of":[17,24,32,90,130,148,298,309,329],"acute":[18],"pulmonary":[19,124],"thromboembolism":[20],"(APTE).":[21],"The":[22,70,114],"aim":[23],"this":[25],"study":[26],"was":[27,80,164],"to":[28,57,326],"investigate":[29],"effects":[31],"thrombolytic":[33,338],"drugs,":[34],"a":[35,48,337],"selective":[36,106,289],"endothelin-1":[37],"receptor":[38],"(ET-1R)":[39],"antagonist":[40,291],"alone":[41,154,199,202],"or":[42,109],"their":[43],"combination":[44,66,100,169,214,226,278,335],"on":[45],"APTE":[46,79],"canine":[49],"model.":[50],"METHODS:":[51],"Twenty":[52],"dogs":[53,71,115],"were":[54,120,139,228,239,265],"randomly":[55],"assigned":[56],"five":[58],"groups:":[59],"sham,":[60],"model,":[61,275],"urokinase":[62],"(UK),":[63],"BQ123,":[64,112],"and":[65,99,134,152,189,200,205,225,232,238,247,253,277,300,311],"(UK":[67],"plus":[68,111],"BQ123).":[69],"sham":[74,77,174],"group":[75,119,175,215,271],"underwent":[76],"surgery.":[78],"induced":[81,317],"four":[85],"groups":[86,101,227,249,279],"by":[87,182,207,318],"intravenous":[88],"injection":[89],"autologous":[91],"blood":[92],"clots.":[93],"Dogs":[94],"UK,":[97,103],"BQ123":[98,104,153,201,224,270,292],"received":[102],"(a":[105],"ET-1R":[107,290,321],"antagonist),":[108],"UK":[110,151,198,248,276],"respectively.":[113],"model":[118,196,246],"given":[121],"saline.":[122],"Mean":[123],"artery":[125],"pressure":[126],"(mPAP),":[127],"serum":[128,301],"concentrations":[129,221,264],"ET-1,":[131],"thromboxane":[132],"(TXB2),":[133],"tumor":[135],"necrosis":[136],"factor":[137],"(TNF)-alpha":[138],"determined":[140],"at":[141],"different":[142],"time":[143],"points":[144],"following":[145],"induction":[147],"APTE.":[149,159,319],"RESULTS:":[150],"markedly":[155],"decreased":[156,206],"mPAP":[157,180,299],"By":[160],"comparison,":[161],"reduction":[163],"more":[165],"significant":[166],"group.":[170],"Compared":[171],"with":[172,336],"((-0.90":[176],"+/-":[177,184,187,191,209,230,234,251,255],"0.61)":[178],"mmHg),":[179],"increased":[181],"(7.44":[183],"1.04),":[185],"(3.42":[186],"1.12)":[188],"(1.14":[190],"0.55)":[192],"mmHg":[193,211],"group,":[197],"groups,":[203],"respectively,":[204,237],"(2.24":[208],"0.67)":[210],"(P":[216,280],"<":[217,260,281],"0.01).":[218,261],"Serum":[219,262],"ET-1":[220,302],"(52.95":[229],"8.53)":[231],"(74.42":[233],"10.27)":[235],"pg/ml,":[236],"significantly":[240,266],"lower":[241,267],"those":[243],"((84.56":[250],"7.44)":[252],"(97.66":[254],"8.31)":[256],"pg/ml":[257],"respectively;":[258],"P":[259],"TNF-alpha":[263],"0.05).":[282],"CONCLUSIONS:":[283],"Our":[284],"results":[285],"indicate":[286],"not":[293],"only":[294],"reduces":[295],"increase":[297],"level,":[303],"but":[304],"also":[305],"inhibits":[306],"production":[308],"TNF-alpha,":[310],"attenuates":[312],"local":[314],"inflammatory":[315],"response":[316],"Selective":[320],"antagonists":[322],"may":[323],"be":[324],"beneficial":[325],"treatment":[328],"APTE,":[330],"particularly":[331],"when":[332],"used":[333],"agent.":[339]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
