{"id":"https://openalex.org/W2368548841","doi":null,"title":"Hypoxia inducible factor-1alpha and leukemic cell differentiation.","display_name":"Hypoxia inducible factor-1alpha and leukemic cell differentiation.","publication_year":2006,"publication_date":"2006-02-25","ids":{"openalex":"https://openalex.org/W2368548841","mag":"2368548841","pmid":"https://pubmed.ncbi.nlm.nih.gov/16489397"},"language":"en","primary_location":{"id":"pmid:16489397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16489397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108139046","display_name":"Guoqiang Chen","orcid":"https://orcid.org/0000-0003-4936-2363","observed_orcids":["https://orcid.org/0000-0003-4936-2363","https://orcid.org/0009-0001-2319-8094"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Qiang Chen","raw_affiliation_strings":["The Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, School of Medical Sciences, Shanghai Jiaotong University, Shanghai 200025, China. chengq@shsmu.edu.cn","The Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, School of Medical Sciences, Shanghai Jiaotong University, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, School of Medical Sciences, Shanghai Jiaotong University, Shanghai 200025, China. chengq@shsmu.edu.cn","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"The Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, School of Medical Sciences, Shanghai Jiaotong University, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895622","display_name":"Zhen-Gang Peng","orcid":"https://orcid.org/0009-0006-9565-258X","observed_orcids":["https://orcid.org/0009-0006-9565-258X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen-Gang Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431762","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0002-2463-1427","observed_orcids":["https://orcid.org/0000-0002-2463-1427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088532176","display_name":"Liping Song","orcid":"https://orcid.org/0000-0001-6558-3137","observed_orcids":["https://orcid.org/0000-0001-6558-3137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Ping Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103909375","display_name":"Yi Jiang","orcid":"https://orcid.org/0009-0007-7004-872X","observed_orcids":["https://orcid.org/0009-0007-7004-872X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110219639","display_name":"Ying Huang","orcid":"https://orcid.org/0000-0002-9537-9345","observed_orcids":["https://orcid.org/0000-0002-9537-9345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025789604","display_name":"Qian Zhao","orcid":"https://orcid.org/0000-0001-8103-8251","observed_orcids":["https://orcid.org/0000-0001-8103-8251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0152,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.79378027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":"1","first_page":"5","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.2159000039100647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.2003999948501587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/leukemia-cell-differentiation","display_name":"leukemia cell differentiation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7599999904632568},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/leukemia-survival","display_name":"leukemia survival","score":0.4790000021457672},{"id":"https://openalex.org/keywords/tumor-infiltration","display_name":"tumor infiltration","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.842267632484436},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7748887538909912},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.7016310095787048},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5638782978057861},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5481966137886047},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5193718075752258},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5116956233978271},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5060240626335144},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43958359956741333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39937829971313477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37294626235961914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3559524118900299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3555718660354614},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3169349133968353},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.269222229719162},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25563809275627136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13159909844398499},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.11056575179100037},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.09472405910491943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0632246732711792},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16489397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16489397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.545.5904","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.545.5904","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.actaps.com.cn/paper/200601/02.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W66419860","https://openalex.org/W78943186","https://openalex.org/W82555676","https://openalex.org/W130028085","https://openalex.org/W182858095","https://openalex.org/W192794212","https://openalex.org/W213807051","https://openalex.org/W1489323849","https://openalex.org/W1553544241","https://openalex.org/W1554600230","https://openalex.org/W1567732942","https://openalex.org/W1632166816","https://openalex.org/W1966969776","https://openalex.org/W1973412670","https://openalex.org/W2001519534","https://openalex.org/W2010549888","https://openalex.org/W2011810742","https://openalex.org/W2014292477","https://openalex.org/W2043887757","https://openalex.org/W2055715830","https://openalex.org/W2057211568","https://openalex.org/W2068488624","https://openalex.org/W2086065240","https://openalex.org/W2099013774","https://openalex.org/W2102470329","https://openalex.org/W2106845461","https://openalex.org/W2108362314","https://openalex.org/W2110164810","https://openalex.org/W2110256313","https://openalex.org/W2114422046","https://openalex.org/W2122465033","https://openalex.org/W2122535638","https://openalex.org/W2127621383","https://openalex.org/W2131627815","https://openalex.org/W2137371083","https://openalex.org/W2142423276","https://openalex.org/W2143914529","https://openalex.org/W2147200112","https://openalex.org/W2153923573","https://openalex.org/W2166566800","https://openalex.org/W2184391500","https://openalex.org/W2227986439","https://openalex.org/W2314037093","https://openalex.org/W2314735784"],"related_works":["https://openalex.org/W7100282049","https://openalex.org/W2166566800","https://openalex.org/W2265291180","https://openalex.org/W158779618","https://openalex.org/W7101087740","https://openalex.org/W2106845461","https://openalex.org/W2136415578","https://openalex.org/W2465655492","https://openalex.org/W2555943836","https://openalex.org/W2110164810"],"abstract_inverted_index":{"Arsenic":[0],"trioxide":[1],"(As2O3,":[2],"ATO)":[3],"is":[4,32],"a":[5],"recently":[6,44],"developed":[7],"drug":[8,31],"for":[9],"the":[10,65,68,84,106,111],"effective":[11],"treatment":[12],"of":[13,29,67,74,78,80,89],"acute":[14,53],"promyelocytic":[15],"leukemia":[16],"(APL).":[17],"Experimental":[18],"studies":[19],"showed":[20],"that":[21,45],"in":[22,38],"vitro":[23],"differentiation-inducing":[24],"ability":[25],"on":[26],"APL":[27],"cells":[28,56],"this":[30],"not":[33],"significant":[34],"compared":[35],"with":[36,72],"its":[37],"vivo":[39],"activity.":[40],"We":[41],"unexpectedly":[42],"found":[43],"hypoxia-mimetic":[46],"agents":[47],"and":[48,76,94,109],"moderate":[49],"real":[50],"hypoxia":[51,62],"triggered":[52],"myeloid":[54],"leukemic":[55,70,81],"to":[57,114],"undergo":[58],"differentiation.":[59],"Furthermore,":[60],"intermittent":[61],"significantly":[63],"prolonged":[64],"survival":[66],"transplanted":[69],"mice":[71],"inhibition":[73],"infiltration":[75],"induction":[77],"differentiation":[79,91],"cells.":[82],"In":[83],"following":[85],"works,":[86],"molecular":[87],"mechanisms":[88],"hypoxia-induced":[90],"were":[92],"investigated":[93],"some":[95],"interesting":[96],"results":[97],"have":[98],"been":[99],"obtained.":[100],"This":[101],"review":[102],"will":[103],"shortly":[104],"summarize":[105],"related":[107],"progresses":[108],"discuss":[110],"questions":[112],"remained":[113],"be":[115],"further":[116],"investigated.":[117]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}