{"id":"https://openalex.org/W2368058723","doi":null,"title":"Expression and significance of hypoxia inducible factor-1\u03b1 during breast carcinogenesis","display_name":"Expression and significance of hypoxia inducible factor-1\u03b1 during breast carcinogenesis","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2368058723","mag":"2368058723"},"language":"en","primary_location":{"id":"mag:2368058723","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGZK200701007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764495136","display_name":"Chinese Journal of Clinical Oncology and Rehabilitation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4353108573","host_organization_name":"China Cancer Research Foundation","host_organization_lineage":["https://openalex.org/P4353108573"],"host_organization_lineage_names":["China Cancer Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Clinical Oncology and Rehabilitation","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103666926","display_name":"Wang Xi-jing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wang Xi-jing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103666926"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27615285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6389999985694885},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tnm-stage","display_name":"TNM stage","score":0.9490000009536743},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-overexpression","display_name":"protein overexpression","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7750290632247925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7615047097206116},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6741348505020142},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.6443920731544495},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6311896443367004},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6266040205955505},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.42587384581565857},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.42302364110946655},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31065741181373596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20771116018295288}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2368058723","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGZK200701007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764495136","display_name":"Chinese Journal of Clinical Oncology and Rehabilitation","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4353108573","host_organization_name":"China Cancer Research Foundation","host_organization_lineage":["https://openalex.org/P4353108573"],"host_organization_lineage_names":["China Cancer Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Clinical Oncology and Rehabilitation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2379175859","https://openalex.org/W2358207227","https://openalex.org/W3029997419","https://openalex.org/W2168014041","https://openalex.org/W2394301834","https://openalex.org/W2057742754","https://openalex.org/W2380051544","https://openalex.org/W2978491584","https://openalex.org/W2122927637","https://openalex.org/W2120807407"],"abstract_inverted_index":{"ObjectiveTo":[0],"investigate":[1],"the":[2],"expression":[3,64,78],"level":[4,79],"of":[5,18,65],"HIF-1\u03b1":[6,19,66],"during":[7],"breast":[8,22,39,69,97],"carcinogenesis":[9],"and":[10,13,60,87],"tumor":[11,53],"progression":[12],"its":[14],"clinicopathological":[15],"significance.Methods":[16],"Expression":[17],"in":[20,28,52,67,76,95],"invasive":[21,68],"carcinomas":[23,70],"(n=":[24],"74),adjacent":[25],"ductal":[26,35,61],"carcinoma":[27],"situ(DCIS)(n=":[29],"13),DCIS":[30],"alone(n=5),ductal":[31],"atypical":[32],"hyperplastic":[33,36,62],"lesions(n=24),usual":[34],"lesions(n=35)and":[37],"normal":[38,58],"epithelia":[40,59],"(n=46)":[41],"was":[42,50,71,80],"analyzed":[43],"by":[44],"immunohistochemistry":[45],"using":[46],"specific":[47],"monoclonal":[48],"antibodies.ResultsHIF-1\u03b1":[49],"overexpressed":[51],"specimens":[54],"as":[55],"compared":[56],"with":[57,82],"lesions.The":[63],"significantly":[72],"higher":[73],"than":[74],"that":[75],"DCIS.HIF-1\u03b1":[77],"correlated":[81],"TNM":[83],"stage,lymph":[84],"node":[85],"metastasis":[86],"histological":[88],"grade(P0.05).ConclusionHIF-1\u03b1":[89],"may":[90],"play":[91],"an":[92],"important":[93],"role":[94],"human":[96],"cancer":[98],"progression.":[99]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}