{"id":"https://openalex.org/W2367972719","doi":null,"title":"Preventive effect of asiaticoside on lipopolysaccharides-induced fever and its influence on levels of inflammatory factors in rats","display_name":"Preventive effect of asiaticoside on lipopolysaccharides-induced fever and its influence on levels of inflammatory factors in rats","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2367972719","mag":"2367972719"},"language":"en","primary_location":{"id":"mag:2367972719","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YLBS200703012.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765063488","display_name":"Zhongguo yaolixue yu dulixue zazhi","issn_l":"1000-3002","issn":["1000-3002"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4327904652","host_organization_name":"Chinese Journal of Pharmacology and Toxicology","host_organization_lineage":["https://openalex.org/P4327904652"],"host_organization_lineage_names":["Chinese Journal of Pharmacology and Toxicology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo yaolixue yu dulixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jing Wan","orcid":"https://orcid.org/0009-0007-9574-9987","observed_orcids":["https://orcid.org/0009-0007-9574-9987"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jing Wan","raw_affiliation_strings":["-Yuan1,LI Hong-Zhong1,LUO Fu-Ling1,ZHOU Qi-Xin1,ZHANG Li2"],"raw_orcid":"https://orcid.org/0009-0007-9574-9987","affiliations":[{"raw_affiliation_string":"-Yuan1,LI Hong-Zhong1,LUO Fu-Ling1,ZHOU Qi-Xin1,ZHANG Li2","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3416225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asiaticoside","display_name":"asiaticoside","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipopolysaccharide-induced-fever","display_name":"lipopolysaccharide-induced fever","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antipyretic-activity","display_name":"antipyretic activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9100000262260437},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.7260000109672546},{"id":"https://openalex.org/keywords/paracetamol-comparison","display_name":"paracetamol comparison","score":0.7379999756813049},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.33399999141693115},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.42500001192092896},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.32899999618530273},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.9399999976158142},{"id":"https://openalex.org/keywords/core-body-temperature","display_name":"core body temperature","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6360903978347778},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.6349773406982422},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.594821572303772},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5490059852600098},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5259963274002075},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.49506130814552307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.480731725692749},{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.4452979564666748},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.4261571764945984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4150403141975403},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3820844888687134},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36059021949768066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.297227680683136},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.26144546270370483},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2566693127155304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1983359158039093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2367972719","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YLBS200703012.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765063488","display_name":"Zhongguo yaolixue yu dulixue zazhi","issn_l":"1000-3002","issn":["1000-3002"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4327904652","host_organization_name":"Chinese Journal of Pharmacology and Toxicology","host_organization_lineage":["https://openalex.org/P4327904652"],"host_organization_lineage_names":["Chinese Journal of Pharmacology and Toxicology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo yaolixue yu dulixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1598910025","https://openalex.org/W2379412183","https://openalex.org/W2365558081","https://openalex.org/W2076944566","https://openalex.org/W1984813271","https://openalex.org/W2375426231","https://openalex.org/W2380747559","https://openalex.org/W2357003616","https://openalex.org/W4385989220","https://openalex.org/W2371108743"],"abstract_inverted_index":{"AIM":[0],"To":[1],"explore":[2],"the":[3,33,104,132,148,155,190,222,236,245],"pyretolytic":[4],"effect":[5,224],"of":[6,20,32,63,73,81,84,109,134,147,158,167,193,208,235,239,244,249],"asiaticoside.METHODS":[7],"Fifty-six":[8],"male":[9],"SD":[10],"rats":[11,47,62,72,83,150,168],"were":[12,53,68,76,87,118,174,212],"randomly":[13],"divided":[14],"into":[15],"normal,model,vehicle,paracetamol":[16],"and":[17,50,65,92,113,131,171,186,200,206,217,242,247],"3":[18,57],"doses":[19],"asiaticoside":[21,55,177],"groups.Rat":[22],"fever":[23,145],"model":[24,66,149,163],"was":[25,101,126,139,181],"made":[26],"by":[27],"ip":[28,41,60,88,96],"lipopolysaccharides(LPS,100":[29],"\u03bcg\u00b7kg-1).The":[30],"changes":[31],"core":[34,165],"temperature(\u0394T)were":[35],"tested":[36],"every":[37],"30":[38,93],"min":[39,94],"after":[40,214],"LPS,and":[42],"lasted":[43],"for":[44,56],"6":[45],"h.The":[46],"in":[48,99,124,136,169,195,198,203,210],"asiaticoside(5,15":[49,170,216],"45":[51,172,178,187,218],"mg\u00b7kg-1)groups":[52,173],"ig":[54,69,77,215],"d":[58],"before":[59],"LPS.The":[61,97],"normal":[64,70],"groups":[67],"saline,and":[71],"vehicle":[74],"group":[75,86,180],"0.5%":[78],"carboxymethyl":[79],"cellulose,instead":[80],"asiaticoside.The":[82],"paracetamol":[85,184],"paracetamol(50":[89],"mg\u00b7kg-1)only":[90],"once":[91],"later":[95],"myeloperoxidase(MPO)activity":[98],"liver":[100,116,137,199,211],"detected":[102,127,140],"with":[103,120,128,141,162],"MPO":[105,240],"kit.The":[106],"protein":[107,191],"expressions":[108],"cyclooxygenase-2(COX-2)in":[110],"brain":[111],"tissue":[112,117,138],"heme":[114],"oxygenase-1(HO-1)in":[115],"analyzed":[119],"Western-blot.The":[121],"prostaglandin":[122],"E2(PGE2)content":[123],"plasma":[125],"enzyme":[129],"immunoassay":[130],"activity":[133,197,205,241,246],"HO-1":[135,209],"Morita":[142],"method.RESULTS":[143],"The":[144],"appearance":[146],"had":[151],"three":[152],"febrile":[153],"phases,and":[154],"maximum":[156],"amplitude":[157],"temperature":[159],"achieved":[160],"2.01\u2103.Compared":[161],"group,the":[164],"temperatures":[166],"obviously":[175],"lower,and":[176],"mg\u00b7kg-1":[179],"similar":[182],"to":[183,232],"group.Asiaticoside(5,15":[185],"mg\u00b7kg-1)obviously":[188],"reduced":[189],"expression":[192,207,248],"COX-2":[194],"brain,MPO":[196],"PGE2":[201],"content":[202],"plasma.The":[204],"elevated":[213],"mg\u00b7kg-1).CONCLUSION":[219],"Asiaticoside":[220],"has":[221],"inhibitory":[223],"on":[225],"fever,and":[226],"this":[227],"action":[228],"possibly":[229],"is":[230],"related":[231],"its":[233],"inhibition":[234],"COX-2/PGE2":[237],"system,reduction":[238],"enhancement":[243],"HO-1.":[250]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
