{"id":"https://openalex.org/W2367892191","doi":null,"title":"Effects of Arachidonic Acid on Growth and Differentiation of Rat Preadipocytes","display_name":"Effects of Arachidonic Acid on Growth and Differentiation of Rat Preadipocytes","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2367892191","mag":"2367892191"},"language":"en","primary_location":{"id":"mag:2367892191","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SWHZ200506005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100423905","display_name":"Hui Li","orcid":"https://orcid.org/0000-0002-5604-0592","observed_orcids":["https://orcid.org/0000-0002-5604-0592"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hui Li","raw_affiliation_strings":["-Xia,YANG Gong-She*,LU Jian-Xiong"],"raw_orcid":"https://orcid.org/0000-0002-5604-0592","affiliations":[{"raw_affiliation_string":"-Xia,YANG Gong-She*,LU Jian-Xiong","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100423905"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19039243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.43700000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.2937000095844269,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.13009999692440033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":1.0},{"id":"https://openalex.org/keywords/preadipocytes","display_name":"preadipocytes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/body-fat-regulation","display_name":"body fat regulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.7099107503890991},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.658851683139801},{"id":"https://openalex.org/C2780806160","wikidata":"https://www.wikidata.org/wiki/Q132442","display_name":"Oil Red O","level":4,"score":0.6227858066558838},{"id":"https://openalex.org/C2779404806","wikidata":"https://www.wikidata.org/wiki/Q488614","display_name":"Fetal bovine serum","level":3,"score":0.5362379550933838},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5194815397262573},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5179628133773804},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5173510909080505},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.490522563457489},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.480537474155426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44832414388656616},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.42162230610847473},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4210107922554016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4141131043434143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41093266010284424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4004896879196167},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39488279819488525},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.38032734394073486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2680650055408478},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25457489490509033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11199581623077393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2367892191","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SWHZ200506005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1578840576","https://openalex.org/W1926712744","https://openalex.org/W1952797651","https://openalex.org/W2039517269","https://openalex.org/W2076335112","https://openalex.org/W2159316366","https://openalex.org/W2168946133","https://openalex.org/W2171968999","https://openalex.org/W2320054147"],"related_works":["https://openalex.org/W2137062460","https://openalex.org/W2528878696","https://openalex.org/W2289307307","https://openalex.org/W2748034720","https://openalex.org/W2044437401","https://openalex.org/W1825321563","https://openalex.org/W2393352142","https://openalex.org/W2533547386","https://openalex.org/W1914461715","https://openalex.org/W2168946133"],"abstract_inverted_index":{"To":[0],"study":[1],"effects":[2],"of":[3,12,19,31,75,122,145,183],"arachidonic":[4],"acid":[5],"(AA)":[6],"on":[7,35,162],"the":[8,73,106,129,143,181],"growth":[9],"and":[10,51,77,79,137,159,165],"differentiation":[11,160],"rat":[13,20,94],"adipocytes,":[14],"a":[15],"cells":[16,26,107,133],"culture":[17],"system":[18],"primary":[21],"preadipocytes":[22,95],"was":[23,45],"established.":[24],"The":[25,90],"treated":[27,96,115],"by":[28,47,84],"different":[29],"concentration":[30],"AA":[32,62,100,114,127,140,155,169],"supplemented":[33],"based":[34],"DMEM":[36],"medium":[37],"containing":[38],"10%":[39],"fetal":[40],"bovine":[41],"serum.":[42],"Cell":[43],"proliferation":[44,108,158],"measured":[46],"trypan":[48],"blue":[49],"exclusion":[50],"methyl":[52],"thiazolyl":[53],"tetrazolium":[54],"(MTT)":[55],"assay":[56,71],"method.":[57],"Hoechst33342":[58],"fluorescence":[59],"staining":[60,69],"observed":[61],"induced":[63],"morphological":[64],"changes.":[65],"Oil":[66],"Red":[67],"O":[68],"extraction":[70],"assess":[72],"degree":[74],"adipogenesis":[76],"differentiation,":[78],"cyclooxygenases-2(COX-2)":[80],"mRNA":[81,147],"were":[82],"detected":[83],"reverse":[85],"transcriptase-polymerase":[86],"chain":[87],"reaction":[88],"(RT-PCR).":[89],"results":[91,152],"showed":[92],"that":[93,154],"with":[97,110,180],"120":[98],"\u03bcmol/L":[99,113,126,139,168],"for":[101,116],"24\u201472":[102],"hours":[103,118],"remarkably":[104],"promoted":[105],"compared":[109],"control,":[111],"160":[112],"48":[117],"could":[119],"induce":[120],"apoptosis":[121],"preadipocytes.":[123],"40,":[124],"80":[125],"decreased":[128],"fat":[130],"content":[131],"in":[132],"at":[134,148],"72":[135],"hours,":[136],"40":[138],"significantly":[141],"up-regulated":[142],"expression":[144],"COX-2":[146,184],"24":[149],"hours.":[150],"This":[151],"indicate":[153],"regulate":[156],"adipocytes":[157],"depended":[161],"treatment":[163],"time":[164],"concentration.":[166],"40\u201480":[167],"maybe":[170],"useful":[171],"to":[172],"control":[173],"body":[174],"fat,":[175],"which":[176],"may":[177],"be":[178],"associated":[179],"increase":[182],"mRNA.":[185]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}