{"id":"https://openalex.org/W2367587124","doi":"https://doi.org/10.1146/annurev.ph.52.030190.002515","title":"Control of Mitochondrial Respiration in the Heart In Vivo","display_name":"Control of Mitochondrial Respiration in the Heart In Vivo","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2367587124","doi":"https://doi.org/10.1146/annurev.ph.52.030190.002515","mag":"2367587124","pmid":"https://pubmed.ncbi.nlm.nih.gov/2158767"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.ph.52.030190.002515","doi":"https://doi.org/10.1146/annurev.ph.52.030190.002515","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.52.030190.002515","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045797457","display_name":"Frederick W. Heineman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. W. Heineman","raw_affiliation_strings":["Laboratory of Cardiac Energetics, National Institutes of Health/NHLBI, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiac Energetics, National Institutes of Health/NHLBI, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089240456","display_name":"Robert S. Balaban","orcid":"https://orcid.org/0000-0003-4086-0948","observed_orcids":["https://orcid.org/0000-0003-4086-0948"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. S. Balaban","raw_affiliation_strings":["Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, Bethesda, UK","institution_ids":["https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8507,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.94436591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"52","issue":"1","first_page":"523","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cardiac-mitochondria","display_name":"heart mitochondria","score":0.6359999775886536},{"id":"https://openalex.org/keywords/distributed-control","display_name":"distributed control","score":0.6000000238418579},{"id":"https://openalex.org/keywords/shared-control","display_name":"shared control","score":0.7860000133514404},{"id":"https://openalex.org/keywords/control-coefficients","display_name":"control coefficients","score":0.8679999709129333},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.8029999732971191},{"id":"https://openalex.org/keywords/oxygen","display_name":"oxygen","score":0.47200000286102295},{"id":"https://openalex.org/keywords/calcium-as-second-messenger","display_name":"calcium as second messenger","score":0.8460000157356262},{"id":"https://openalex.org/keywords/myosin-atpase","display_name":"myosin ATPase","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dehydrogenase","display_name":"dehydrogenase","score":0.875},{"id":"https://openalex.org/keywords/in-vivo-regulation","display_name":"in vivo regulation","score":0.4620000123977661},{"id":"https://openalex.org/keywords/isolated-myocytes","display_name":"isolated myocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/rate-limiting-step","display_name":"rate-determining step","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5560938119888306},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5422199368476868},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.4513288736343384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44358959794044495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4394332468509674},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4334741234779358},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.413515567779541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3826863169670105},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.ph.52.030190.002515","doi":"https://doi.org/10.1146/annurev.ph.52.030190.002515","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.ph.52.030190.002515","pdf_url":null,"source":{"id":"https://openalex.org/S196366644","display_name":"Annual Review of Physiology","issn_l":"0066-4278","issn":["0066-4278","1545-1585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Physiology","raw_type":"journal-article"},{"id":"pmid:2158767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2158767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.5799999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W89766373","https://openalex.org/W142208213","https://openalex.org/W1542197083","https://openalex.org/W1542605593","https://openalex.org/W1586233686","https://openalex.org/W1596258111","https://openalex.org/W1666357690","https://openalex.org/W1988951065","https://openalex.org/W1990220729","https://openalex.org/W1994290950","https://openalex.org/W1995574482","https://openalex.org/W1997138531","https://openalex.org/W1998749030","https://openalex.org/W2002357266","https://openalex.org/W2014167033","https://openalex.org/W2025532642","https://openalex.org/W2028436089","https://openalex.org/W2052360006","https://openalex.org/W2052899556","https://openalex.org/W2053116782","https://openalex.org/W2060801890","https://openalex.org/W2065554744","https://openalex.org/W2073756661","https://openalex.org/W2142046597","https://openalex.org/W2153420911","https://openalex.org/W2175985062","https://openalex.org/W2178930977","https://openalex.org/W2231979385","https://openalex.org/W2276148590","https://openalex.org/W2313021176","https://openalex.org/W2336992222","https://openalex.org/W2401316009","https://openalex.org/W2462415355"],"related_works":["https://openalex.org/W408524314","https://openalex.org/W962851918","https://openalex.org/W2014167033","https://openalex.org/W20628358","https://openalex.org/W1967896144","https://openalex.org/W2078343516","https://openalex.org/W1978897601","https://openalex.org/W1923133867","https://openalex.org/W2000300491","https://openalex.org/W4242411876"],"abstract_inverted_index":{"After":[0],"reviewing":[1],"the":[2,5,8,18,25,37,82,95,140,143,153,181,190,207,241,247,255,280,283,331,334,351,355,360,369,377,386,400],"controversies":[3],"in":[4,40,61,65,98,290,305,310,333],"literature":[6],"surrounding":[7,371],"regulation":[9,117],"of":[10,32,43,89,118,142,155,158,161,184,206,251,257,271,319,330,354,363,403],"oxidative":[11,291,404],"phosphorylation,":[12],"a":[13,41,46,63,110,119,123,220,269,396],"unifying":[14],"theory":[15,250],"to":[16,29,116,152,168,279,394],"integrate":[17],"disparate":[19],"results":[20],"would":[21],"be":[22,53,76,217,392,395],"welcome.":[23],"Following":[24],"traditional":[26],"biochemical":[27,47],"approach":[28,57],"identifying":[30],"sites":[31,157,358],"control,":[33,159],"one":[34,175,344],"searches":[35],"for":[36,180,228,287,296,303,328,367],"rate-limiting":[38,72,107],"step":[39,96],"series":[42],"reactions":[44],"(i.e.":[45],"pathway)":[48],"that,":[49],"presumably,":[50],"will":[51,349],"not":[52,59,102,260],"at":[54,314,322],"equilibrium.":[55],"This":[56],"has":[58,264],"succeeded":[60],"locating":[62],"reaction":[64,111],"cardiac":[66],"respiratory":[67],"control":[68,141,183,253,285,301,318,347],"that":[69,104,136,342,376],"is":[70,97,106,224,259,374],"singularly":[71],"and":[73,202,211,243,263,381],"may":[74,216],"actually":[75],"contributing":[77],"to,":[78],"rather":[79],"than":[80],"clarifying,":[81],"problem.":[83],"There":[84],"are":[85,133,383],"two":[86],"major":[87,397],"criticisms":[88],"this":[90,147,229,277,315],"approach.":[91],"First,":[92],"even":[93],"if":[94],"disequilibrium,":[99],"it":[100,105,233,325],"does":[101],"prove":[103],"(26).":[108,299],"Second,":[109],"near":[112],"equilibrium":[113],"can":[114,235],"contribute":[115,164],"system":[120],"(37).":[121],"In":[122,170],"complex,":[124],"multiple-reaction":[125],"integrated":[126],"pathway":[127,148],"such":[128,375],"as":[129,232],"mitochondrial":[130,364],"respiration":[131,258,304,320],"there":[132],"many":[134],"steps":[135,289],"could":[137,163,326,390],"potentially":[138],"share":[139],"overall":[144],"system.":[145],"Thus":[146],"easily":[149],"lends":[150],"itself":[151],"possibility":[154],"multiple":[156,323],"each":[160],"which":[162,186],"by":[165,189,219,246],"varying":[166],"degrees":[167],"regulation.":[169],"Figure":[171],"3":[172],"we":[173],"present":[174],"possible":[176],"network":[177],"(undoubtedly":[178],"incomplete)":[179],"distributed":[182],"respiration,":[185],"incorporates":[187],"contributions":[188],"cellular":[191],"redox":[192,379],"state":[193,380],"(supply),":[194],"phosphate":[195,209,387],"metabolite":[196,388],"concentrations":[197,389],"(either":[198],"kinetic":[199],"or":[200,308,340,345],"thermodynamic),":[201],"oxygen.":[203],"The":[204,249,300],"coordination":[205],"dehydrogenases,":[208],"metabolites,":[210],"myosin":[212],"ATPase":[213],"activity":[214],"(work)":[215],"orchestrated":[218],"second":[221],"messenger.":[222],"Calcium":[223],"an":[225],"attractive":[226],"candidate":[227],"role":[230],"(15)":[231],"simultaneously":[234],"modulate":[236],"reducing":[237],"equivalent":[238],"supply":[239],"via":[240],"dehydrogenases":[242],"ATP":[244],"use":[245],"myofibrils.":[248],"shared":[252],"along":[254],"path":[256],"new":[261],"(37),":[262],"been":[265,294],"gaining":[266],"support":[267],"from":[268],"variety":[270],"laboratories":[272],"(3,":[273],"9,":[274],"26).":[275],"Applying":[276],"concept":[278],"experimental":[281],"setting,":[282],"relative":[284,352],"strengths":[286],"various":[288],"phosphorylation":[292],"have":[293],"reported":[295],"isolated":[297,306,372],"mitochondria":[298],"coefficients":[302],"myocytes":[307,373],"hearts":[309],"vivo":[311],"remain":[312],"unknown":[313],"time.":[316],"If":[317],"occurs":[321],"sites,":[324],"account":[327],"much":[329],"disagreement":[332],"literature.":[335],"Experimental":[336],"conditions,":[337],"whether":[338],"intentional":[339],"inadvertent,":[341],"saturate":[343],"more":[346],"mechanisms":[348],"increase":[350],"effect":[353],"other":[356],"regulatory":[357],"on":[359],"remaining":[361],"range":[362],"function.":[365],"If,":[366],"example,":[368],"medium":[370],"cytosolic":[378],"pO2":[382],"very":[384],"high,":[385],"logically":[391],"expected":[393],"factor":[398],"influencing":[399],"observed":[401],"rate":[402],"phosphorylation.(ABSTRACT":[405],"TRUNCATED":[406],"AT":[407],"400":[408],"WORDS)":[409]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}