{"id":"https://openalex.org/W2365615677","doi":null,"title":"Study on peginterferon alfa-2b in combination with ribavirin for chronic hepatitis C","display_name":"Study on peginterferon alfa-2b in combination with ribavirin for chronic hepatitis C","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2365615677","mag":"2365615677"},"language":"en","primary_location":{"id":"mag:2365615677","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-HNZD200609001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764666761","display_name":"Journal of Practical Diagnosis and Therapy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Practical Diagnosis and Therapy","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110365579","display_name":"Tang Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tang Fu","raw_affiliation_strings":["'ai,YANG Yuxiu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"'ai,YANG Yuxiu","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110365579"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2195,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6719344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8519999980926514},{"id":"https://openalex.org/keywords/peginterferon-alfa-2b","display_name":"peginterferon alfa-2b","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.9350000023841858},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9909999966621399},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.609000027179718},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8330000042915344},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9713760614395142},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.9710545539855957},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.7140741944313049},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.649671733379364},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6427631974220276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.635967493057251},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5391858220100403},{"id":"https://openalex.org/C2781228144","wikidata":"https://www.wikidata.org/wiki/Q6046441","display_name":"Interferon alfa","level":4,"score":0.5141282677650452},{"id":"https://openalex.org/C2776235749","wikidata":"https://www.wikidata.org/wiki/Q420056","display_name":"Peginterferon alfa-2a","level":5,"score":0.49839138984680176},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4836043417453766},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.4436790347099304},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.41379866003990173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21321892738342285},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0935119092464447}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2365615677","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-HNZD200609001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764666761","display_name":"Journal of Practical Diagnosis and Therapy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Practical Diagnosis and Therapy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2375523704","https://openalex.org/W2387534557","https://openalex.org/W3031530972","https://openalex.org/W2182218967","https://openalex.org/W2027545702","https://openalex.org/W2394144301","https://openalex.org/W2356835843","https://openalex.org/W2150875695","https://openalex.org/W2369304991","https://openalex.org/W2008759450"],"abstract_inverted_index":{"Objective":[0],"To":[1],"evaluate":[2],"the":[3,38,92,95,99,102,125,131],"therapeutic":[4],"effect":[5],"and":[6,29],"safety":[7],"of":[8,46,72,94,98,127,138,152],"peginterferon":[9,47,139],"alfa-2b":[10,48,74,140,154],"plus":[11,53,80,145,160],"ribavirin":[12,54,81,146],"for":[13,60,87],"chronic":[14,20,134],"hepatitis":[15,21,135],"C.Methods":[16],"Twenty-nine":[17],"patients":[18,36,64,100,132],"with":[19,106,133],"C":[22],"were":[23],"randomly":[24],"divided":[25],"into":[26],"treatment":[27,39,103],"group(n=20)":[28],"control":[30,66,110],"group(n=9)":[31],"in":[32,37,65,101,109,124],"a":[33,51,78,112,143,158],"2\u22361":[34],"ratio.The":[35],"group":[40,67],"received":[41,68],"40":[42],"or":[43],"50":[44],"\u03bcg":[45],"subcutaneously":[49,75],"once":[50,142],"week":[52,79,144,159],"orally":[55,82],"750\uff5e1050":[56,83],"mg":[57,84],"per":[58,85],"day":[59,86],"48":[61,88],"weeks":[62,89],"totally.The":[63],"3":[69],"million":[70],"units":[71],"interferon":[73,153],"three":[76,156],"times":[77,157],"totally.Results":[90],"At":[91],"end":[93],"follow-up":[96],"period,85.00%":[97],"group,as":[104],"compared":[105],"44.44":[107],"%":[108],"group,had":[111],"sustained":[113],"virologic":[114],"response(P0.05).There":[115],"was":[116],"no":[117],"significant":[118],"difference":[119],"between":[120],"these":[121],"two":[122],"groups":[123],"rate":[126],"adverse":[128],"effect.Conclusion":[129],"In":[130],"C,a":[136],"regimen":[137],"given":[141,155],"is":[147],"more":[148],"effective":[149],"than":[150],"that":[151],"ribavirin,with":[161],"similar":[162],"safety.":[163]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}