{"id":"https://openalex.org/W2365060979","doi":null,"title":"[Antiandrogen treatment for nude mice model with ectopic transplanted human HCC].","display_name":"[Antiandrogen treatment for nude mice model with ectopic transplanted human HCC].","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2365060979","mag":"2365060979","pmid":"https://pubmed.ncbi.nlm.nih.gov/10923491"},"language":"zh","primary_location":{"id":"pmid:10923491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10923491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L Liang","raw_affiliation_strings":["Division of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039806235","display_name":"Michael L. Lu","orcid":"https://orcid.org/0000-0002-4659-943X","observed_orcids":["https://orcid.org/0000-0002-4659-943X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101759888","display_name":"Jianwen Huang","orcid":"https://orcid.org/0009-0002-0356-1930","observed_orcids":["https://orcid.org/0009-0002-0356-1930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.3652863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"78","issue":"4","first_page":"299","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/flutamide","display_name":"flutamide","score":0.9380000233650208},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":1.0},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ectopic-transplantation","display_name":"ectopic transplantation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2778313021","wikidata":"https://www.wikidata.org/wiki/Q418669","display_name":"Flutamide","level":5,"score":0.8976943492889404},{"id":"https://openalex.org/C2779322244","wikidata":"https://www.wikidata.org/wiki/Q574820","display_name":"Antiandrogen","level":4,"score":0.8366323709487915},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6243747472763062},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5248734354972839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48312994837760925},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.47450870275497437},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46540743112564087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4585658311843872},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.45544078946113586},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4009513854980469},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3706324100494385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34870925545692444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3013305366039276},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22281652688980103},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15106606483459473},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.13491743803024292},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005485","descriptor_name":"Flutamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10923491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10923491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue za zhi","raw_type":"English Abstract"},{"id":"mag:2365060979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10923491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3152274010","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHYX804.028.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2751117172","display_name":"Zhonghua yixue zazhi","issn_l":"0376-2491","issn":["0376-2491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2397432382","https://openalex.org/W2052634030","https://openalex.org/W2391391138","https://openalex.org/W2048119947","https://openalex.org/W2117502057","https://openalex.org/W196749151","https://openalex.org/W2033113959","https://openalex.org/W1781229955","https://openalex.org/W1982322852","https://openalex.org/W1969383085"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,23,70,88,153,165],"effect":[4,64],"of":[5,47,65,75,91,114,143,156],"antiandrogen":[6,159],"on":[7],"hepatocellular":[8],"carcinoma":[9],"(HCC).":[10],"METHODS:":[11],"Nude":[12,36],"mice":[13,37],"model":[14],"with":[15,38,44,87],"orthotopic":[16],"transplanted":[17,40],"human":[18],"HCC":[19,41],"was":[20,33,67,99,138],"constructed":[21],"and":[22,29,59,79,83,104,118,158],"androgen":[24],"receptor":[25],"(AR)":[26],"in":[27,77,81,93,97,102,108,164],"tumor":[28,82,92,98,112],"surrounding":[30],"liver":[31],"tissue":[32,85],"assayed":[34],"dynamically.":[35],"ectopic":[39],"were":[42],"treated":[43],"flutamide":[45],"(blocker":[46],"AR)":[48],"at":[49,152],"two":[50],"different":[51],"dosages":[52],"(Group":[53],"F1,":[54,116],"F2),":[55],"normal":[56],"saline(Group":[57],"C),":[58],"anticancer":[60],"drug(Group":[61],"M).":[62],"The":[63,73,111],"treatments":[66],"compared":[68],"among":[69],"groups.":[71,110],"RESULTS:":[72],"quantity":[74],"AR":[76,96],"nucleus":[78],"cytoplasm":[80],"tumor-surrounding":[84],"decreased":[86],"increasing":[89],"size":[90],"proper":[94],"order.":[95],"significantly":[100,139],"less":[101],"F1":[103],"F2":[105,117],"groups":[106],"than":[107,141],"other":[109],"weight":[113],"group":[115,144],"C":[119],"had":[120],"no":[121],"significant":[122],"difference":[123],"(1.36":[124],"+/-":[125,129,133],"0.82":[126],"g,":[127,131,135],"2.66":[128],"1.40":[130],"1.66":[132],"0.79":[134],"respectively),":[136],"but":[137],"higher":[140],"that":[142],"M.":[145],"CONCLUSION:":[146],"Androgen":[147],"may":[148,161],"play":[149],"a":[150],"role":[151],"initial":[154],"stage":[155],"hepatocarcinogenesis,":[157],"therapy":[160],"be":[162],"ineffective":[163],"established":[166],"tumor.":[167]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}