{"id":"https://openalex.org/W2364833797","doi":"https://doi.org/10.3760/cma.j.issn.1673-4149.2006.02.020","title":"High mobility group box-1 protein and its role in sepsis","display_name":"High mobility group box-1 protein and its role in sepsis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2364833797","doi":"https://doi.org/10.3760/cma.j.issn.1673-4149.2006.02.020","mag":"2364833797"},"language":"en","primary_location":{"id":"mag:2364833797","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWLX200602020.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306513632","display_name":"Inter J Epidemiol Infect Dis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Epidemiology and Infectious Disease","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086609267","display_name":"Fan Xue-gon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"\u5f6d\u5efa\u5e73","raw_affiliation_strings":["410008,\u957f\u6c99,\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u611f\u67d3\u75c5\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"410008,\u957f\u6c99,\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u611f\u67d3\u75c5\u79d1","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":null,"display_name":"\u8303\u5b66\u5de5","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"\u8303\u5b66\u5de5","raw_affiliation_strings":["410008,\u957f\u6c99,\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u611f\u67d3\u75c5\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"410008,\u957f\u6c99,\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u611f\u67d3\u75c5\u79d1","institution_ids":["https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086609267"],"corresponding_institution_ids":["https://openalex.org/I4210159865"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25392008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"02","first_page":"129","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.2896000146865845,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-box-1-protein","display_name":"high mobility group box 1 protein","score":0.878000020980835},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hmgb1-secretion","display_name":"HMGB1 secretion","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.878000020980835},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.9808470010757446},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.9231165647506714},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8392579555511475},{"id":"https://openalex.org/C30683889","wikidata":"https://www.wikidata.org/wiki/Q926211","display_name":"High-mobility group","level":3,"score":0.7617772221565247},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.7096410989761353},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49277833104133606},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4837455749511719},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.483141154050827},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4608689248561859},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45294731855392456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4209222197532654},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4031195640563965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3799515962600708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24957865476608276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12896937131881714}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2364833797","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWLX200602020.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306513632","display_name":"Inter J Epidemiol Infect Dis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Epidemiology and Infectious Disease","raw_type":null},{"id":"mag:3029334673","doi":"https://doi.org/10.3760/cma.j.issn.1673-4149.2006.02.020","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN331340200602/312295.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306513632","display_name":"Inter J Epidemiol Infect Dis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Inter J Epidemiol Infect Dis","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2352020732","https://openalex.org/W2016169910","https://openalex.org/W2020942709","https://openalex.org/W2352398837","https://openalex.org/W2102205743","https://openalex.org/W3165476197","https://openalex.org/W2385018882","https://openalex.org/W2128556033","https://openalex.org/W22914510","https://openalex.org/W2372969963"],"abstract_inverted_index":{"High":[0],"mobility":[1],"group":[2],"box-1":[3],"protein":[4],"locates":[5],"nuclei":[6],"and":[7,17,23,30,50,69,77,82],"cytoplasm":[8],"in":[9,13,56,62,72,86],"normal":[10],"condition.It":[11],"involves":[12],"maintaining":[14],"nucleosome":[15],"structure":[16],"regulation":[18],"of":[19,75],"gene":[20],"transcription.When":[21],"immunocytes(i.e,monocytes":[22],"dendritic":[24],"cells)":[25],"are":[26],"stimulated":[27],"by":[28],"LPS":[29],"cytokines,HMGB1":[31],"can":[32],"be":[33,66,79],"secreted":[34],"into":[35],"the":[36],"extracellular":[37],"milieu.It":[38],"acts":[39],"as":[40],"proinflammatory":[41,48],"cytokines,activates":[42],"inflammatory":[43],"responses.Being":[44],"different":[45],"from":[46,97],"early":[47],"cytokines(i.e,TNF-\u03b1":[49],"IL-1),HMGB1":[51],"is":[52],"a":[53,67],"late":[54],"mediator":[55],"sepsis.HMGB1":[57],"plays":[58],"an":[59,80],"important":[60,81],"role":[61],"sepsis,so":[63],"it":[64],"may":[65,78],"convenient":[68],"practical":[70],"index":[71],"evaluating":[73],"severity":[74],"sepsis":[76],"new":[83],"therapeutic":[84],"target":[85],"sepsis.The":[87],"experimental":[88],"study":[89],"showed":[90],"that":[91],"anti-HMGB1":[92],"treatment":[93],"could":[94],"rescue":[95],"animals":[96],"lethal":[98],"sepsis.":[99]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
