{"id":"https://openalex.org/W2364516398","doi":null,"title":"The Regulation of Lymphocyte Ativation by Inhibitory Receptors","display_name":"The Regulation of Lymphocyte Ativation by Inhibitory Receptors","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2364516398","mag":"2364516398"},"language":"en","primary_location":{"id":"mag:2364516398","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-GYMF200604001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764401008","display_name":"International Journal of Immunology","issn_l":"2329-1753","issn":["2329-1753","2329-177X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319272","host_organization_name":"Science Publishing Group","host_organization_lineage":["https://openalex.org/P4310319272"],"host_organization_lineage_names":["Science Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Immunology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034957547","display_name":"Xuetao Cao","orcid":"https://orcid.org/0000-0001-9677-7647","observed_orcids":["https://orcid.org/0000-0001-9677-7647"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuetao Cao","raw_affiliation_strings":["Institute of Immunology Zhejiang University,Hangzhou 310031,China)"],"raw_orcid":"https://orcid.org/0000-0001-9677-7647","affiliations":[{"raw_affiliation_string":"Institute of Immunology Zhejiang University,Hangzhou 310031,China)","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034957547"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2418325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2280000001192093,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibitory-receptors","display_name":"inhibitory receptors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/inhibitory-fc-receptor","display_name":"inhibitory Fc receptor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/negative-signaling","display_name":"negative signaling","score":0.4480000138282776},{"id":"https://openalex.org/keywords/immune-checkpoint-modulation","display_name":"immune checkpoint modulation","score":0.4440000057220459},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.8469928503036499},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7745667695999146},{"id":"https://openalex.org/C103474210","wikidata":"https://www.wikidata.org/wiki/Q142851","display_name":"Immune receptor","level":3,"score":0.7560998201370239},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5688747763633728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5628519058227539},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.458556592464447},{"id":"https://openalex.org/C14200731","wikidata":"https://www.wikidata.org/wiki/Q1752866","display_name":"D2-like receptor","level":5,"score":0.44682636857032776},{"id":"https://openalex.org/C2780237676","wikidata":"https://www.wikidata.org/wiki/Q18052115","display_name":"BTLA","level":4,"score":0.4448031187057495},{"id":"https://openalex.org/C203270574","wikidata":"https://www.wikidata.org/wiki/Q24725121","display_name":"Class C GPCR","level":5,"score":0.43086493015289307},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4233925938606262},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4041668176651001},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2988615334033966},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.17599192261695862},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14476042985916138},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.09110429883003235},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.08919870853424072}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2364516398","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-GYMF200604001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764401008","display_name":"International Journal of Immunology","issn_l":"2329-1753","issn":["2329-1753","2329-177X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319272","host_organization_name":"Science Publishing Group","host_organization_lineage":["https://openalex.org/P4310319272"],"host_organization_lineage_names":["Science Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Immunology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160675434","https://openalex.org/W2028658996","https://openalex.org/W1922124689","https://openalex.org/W1966930760","https://openalex.org/W2413539214","https://openalex.org/W1513771042","https://openalex.org/W4281712401","https://openalex.org/W3039232686","https://openalex.org/W4207044427","https://openalex.org/W2054753509"],"abstract_inverted_index":{"The":[0],"function":[1],"of":[2,9,38,69,75],"leukocytes":[3],"is":[4],"regulated":[5],"by":[6],"the":[7,30,61],"integration":[8],"positive":[10],"and":[11,28,48,65,93],"negative":[12],"signals":[13],"received":[14],"through":[15],"cell":[16],"surface":[17],"receptors.":[18,71],"Inhibitory":[19],"receptors":[20,47,50],"can":[21],"limit,":[22],"terminate":[23],"and/or":[24],"attenuate":[25],"immune":[26],"responses,":[27],"maintain":[29],"homeostasis.":[31],"There":[32],"are":[33,57],"three":[34],"main":[35],"identified":[36],"groups":[37],"inhibitory":[39,42,45,49,77],"receptors,":[40,44],"including":[41],"MHC-recognized":[43],"Fc":[46],"binding":[51],"to":[52,59],"B7":[53],"family":[54],"members.":[55],"Studies":[56],"beginning":[58],"reveal":[60],"categories,":[62],"ligands,":[63],"mechanisms":[64,78],"functions":[66],"in":[67,88],"diseases":[68],"these":[70,76,86],"A":[72],"better":[73],"understanding":[74],"will":[79],"provide":[80],"a":[81],"foundation":[82],"for":[83],"therapeutically":[84],"modulating":[85],"processes":[87],"antiviral":[89],"immunity,":[90],"anti-tumor":[91],"responses":[92],"autoimmune":[94],"diseases.":[95]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}