{"id":"https://openalex.org/W2364312993","doi":null,"title":"[Therapy of aplastic anemia with autologous peripheral mononuclear cells treated by IL-2 and GM-CSF in culture: a long-term follow-up report on 49 patients].","display_name":"[Therapy of aplastic anemia with autologous peripheral mononuclear cells treated by IL-2 and GM-CSF in culture: a long-term follow-up report on 49 patients].","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2364312993","mag":"2364312993","pmid":"https://pubmed.ncbi.nlm.nih.gov/21729571"},"language":"zh","primary_location":{"id":"pmid:21729571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21729571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077619534","display_name":"Ling-Zhen Chen","orcid":"https://orcid.org/0000-0002-1423-281X","observed_orcids":["https://orcid.org/0000-0002-1423-281X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling-Zhen Chen","raw_affiliation_strings":["Department of Hematology, Guangzhou Municipal 12th Hospital, Guangzhou 510620, Guangdong Province, China. yunhe668@yahoo.com.cn","Department of Hematology, Guangzhou Municipal 12th Hospital, Guangzhou 510620, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Guangzhou Municipal 12th Hospital, Guangzhou 510620, Guangdong Province, China. yunhe668@yahoo.com.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Hematology, Guangzhou Municipal 12th Hospital, Guangzhou 510620, Guangdong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380043","display_name":"Jiayu Chen","orcid":"https://orcid.org/0000-0001-9449-9321","observed_orcids":["https://orcid.org/0000-0001-9449-9321","https://orcid.org/0009-0002-6500-2835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-Yu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102908404","display_name":"Wei Hui Yu","orcid":"https://orcid.org/0000-0003-3139-9360","observed_orcids":["https://orcid.org/0000-0003-3139-9360"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025968588","display_name":"Jin\u2010Ming Wu","orcid":"https://orcid.org/0000-0002-1821-239X","observed_orcids":["https://orcid.org/0000-0002-1821-239X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Ming Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031040196","display_name":"Yu Zhan","orcid":"https://orcid.org/0000-0002-7551-5039","observed_orcids":["https://orcid.org/0000-0002-7551-5039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Zhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ke-Xin Feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ke-Xin Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020585604","display_name":"Demao Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De-Mao Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25790934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"3","first_page":"781","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autologous-peripheral-blood-mononuclear-cells","display_name":"autologous peripheral blood mononuclear cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.968999981880188},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.953000009059906},{"id":"https://openalex.org/keywords/hematopoietic-recovery","display_name":"hematopoietic recovery","score":0.7379999756813049},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9200000166893005},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.5090000033378601},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7009999752044678},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7116426825523376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6456788778305054},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6237571835517883},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5651576519012451},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.5584469437599182},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5069940090179443},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40500855445861816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38085228204727173},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2033916711807251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1588875651359558},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D036102","descriptor_name":"Peripheral Blood Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21729571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21729571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030028916","https://openalex.org/W272209951","https://openalex.org/W260184188","https://openalex.org/W2326695376","https://openalex.org/W2615879324","https://openalex.org/W2407783372","https://openalex.org/W3031537126","https://openalex.org/W2561332692","https://openalex.org/W2029440317","https://openalex.org/W2074482378"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,94,110,126],"purposed":[3],"to":[4,51,112,128,178,191,198,224,258],"evaluate":[5],"the":[6,10,31,114,130,155,192,199,207,217,237,259],"long-term":[7,228],"outcome":[8],"and":[9,24,60,69,74,104,120,149,167,194,244,249],"safety":[11],"of":[12,33,41,67,98,133,151,182,210,261],"autologous":[13],"peripheral":[14,99,115],"blood":[15],"mononuclear":[16],"cells":[17],"(PBMNC)":[18],"treated":[19,241],"by":[20,96,242],"interleukin":[21],"2":[22],"(IL-2)":[23],"granulocyte-macrophage":[25],"colony":[26],"stimulating":[27],"factor":[28],"(GM-CSF)":[29],"in":[30,46,65,160,187,213,256],"therapy":[32,40],"patients":[34,43,189,215],"with":[35,239],"aplastic":[36],"anemia":[37],"(AA).":[38],"The":[39,141,173,180,251],"49":[42],"admitted":[44],"BG":[45],"hospital":[47],"from":[48,219],"April":[49],"2001":[50],"December":[52],"2007":[53],"were":[54,58,72,83,147,159,185,231],"analyzed":[55],"retrospectively.":[56],"PBMNC":[57,82,240],"isolated":[59],"cultured":[61],"for":[62,87],"48":[63],"hours":[64],"presence":[66],"IL-2":[68,243],"GM-CSF.":[70],"Cells":[71],"collected,":[73],"6":[75],"\u00d7":[76,80],"10(6)":[77],"-":[78,89],"1":[79],"10(8)":[81],"intravenously":[84],"injected":[85],"weekly":[86],"4":[88,168],"22":[90],"months.":[91],"Hematopoietic":[92],"recovery":[93],"evaluated":[95],"examinations":[97],"blood,":[100],"bone":[101,105],"marrow":[102,106],"aspirates":[103],"biopsy.":[107],"Flow":[108],"cytometry":[109],"used":[111],"assess":[113],"T":[116,134],"cell":[117,135,203,262],"subsets":[118,184],"before":[119],"after":[121,202],"treatment.":[122],"Polymerase":[123],"chain":[124],"reaction":[125],"performed":[127],"observe":[129],"clonal":[131,208],"diversity":[132,209],"receptor":[136],"variable":[137],"\u03b2-chain":[138],"(TCR-V\u03b2)":[139],"recombination.":[140],"results":[142],"showed":[143,170,216],"that":[144,236],"37":[145],"cases":[146,158,164,169,196],"cured":[148],"none":[150],"them":[152],"relapsed":[153],"during":[154],"follow-up,":[156],"5":[157],"partial":[161],"remission,":[162],"3":[163],"got":[165],"improvement,":[166],"no":[171],"response.":[172],"total":[174],"efficiency":[175],"reached":[176],"up":[177],"91.8%.":[179],"ratios":[181],"CD4(+)/CD8(+)":[183],"abnormal":[186],"39":[188],"prior":[190],"treatment,":[193],"31":[195],"restored":[197],"normal":[200],"range":[201],"transfusions.":[204],"Analysis":[205],"on":[206],"TCR-V\u03b2":[211],"recombination":[212],"11":[214],"transition":[218],"monoclonal":[220],"or":[221],"biclonal":[222],"spectratype":[223],"polyclonal":[225],"one.":[226],"No":[227],"side":[229],"effects":[230],"documented.":[232],"It":[233],"is":[234,246],"concluded":[235],"treatment":[238],"GM-CSF":[245],"generally":[247],"safe":[248],"effective.":[250],"underlying":[252],"mechanisms":[253],"may":[254],"be":[255],"relation":[257],"restoration":[260],"immunity.":[263]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}