{"id":"https://openalex.org/W2364062175","doi":null,"title":"Interaction Between Beta-Catenin and EGFR Expression by Immunohistochemistry Identifies Prognostic Subgroups in Early High-risk Triple-negative Breast Cancer.","display_name":"Interaction Between Beta-Catenin and EGFR Expression by Immunohistochemistry Identifies Prognostic Subgroups in Early High-risk Triple-negative Breast Cancer.","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2364062175","mag":"2364062175","pmid":"https://pubmed.ncbi.nlm.nih.gov/27127145"},"language":"en","primary_location":{"id":"pmid:27127145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27127145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078277705","display_name":"Sotirios Lakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sotirios Lakis","raw_affiliation_strings":["Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece slakis@auth.gr","1Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece slakis@auth.gr","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"1Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044568139","display_name":"Stefanos Dimoudis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stefanos Dimoudis","raw_affiliation_strings":["Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051365519","display_name":"Vassiliki Kotoula","orcid":"https://orcid.org/0000-0002-8657-9732","observed_orcids":["https://orcid.org/0000-0002-8657-9732"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vassiliki Kotoula","raw_affiliation_strings":["Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece Department of Pathology, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece Department of Pathology, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056440040","display_name":"Zoi Alexopoulou","orcid":"https://orcid.org/0000-0002-1785-1800","observed_orcids":["https://orcid.org/0000-0002-1785-1800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoi Alexopoulou","raw_affiliation_strings":["Health Data Specialists Ltd., Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Data Specialists Ltd., Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113616334","display_name":"Ioannis S. Kostopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Kostopoulos","raw_affiliation_strings":["Department of Pathology, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030925125","display_name":"Triantafyllia \u039aoletsa","orcid":"https://orcid.org/0000-0002-4435-3532","observed_orcids":["https://orcid.org/0000-0002-4435-3532"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Triantafyllia Koletsa","raw_affiliation_strings":["Department of Pathology, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005181965","display_name":"Mattheos Bobos","orcid":"https://orcid.org/0000-0001-5662-9201","observed_orcids":["https://orcid.org/0000-0001-5662-9201"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Mattheos Bobos","raw_affiliation_strings":["Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Thessalon\u00edki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Thessalon\u00edki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046379450","display_name":"Eleni T. Timotheadou","orcid":"https://orcid.org/0000-0003-2545-8926","observed_orcids":["https://orcid.org/0000-0003-2545-8926"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni Timotheadou","raw_affiliation_strings":["Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041321317","display_name":"Irene Papaspirou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Irene Papaspirou","raw_affiliation_strings":["Department of Pathology, Alexandra Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Alexandra Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004966307","display_name":"Ioannis Efstratiou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Efstratiou","raw_affiliation_strings":["Department of Pathology, Papageorgiou Hospital, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Papageorgiou Hospital, Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039349296","display_name":"Gerasimos Aravantinos","orcid":"https://orcid.org/0000-0002-2106-1713","observed_orcids":["https://orcid.org/0000-0002-2106-1713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerasimos Aravantinos","raw_affiliation_strings":["Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034625178","display_name":"Vasilios Karavasilis","orcid":"https://orcid.org/0000-0002-5806-9399","observed_orcids":["https://orcid.org/0000-0002-5806-9399"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vasilios Karavasilis","raw_affiliation_strings":["Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046758725","display_name":"Flora Zagouri","orcid":"https://orcid.org/0000-0001-7153-6556","observed_orcids":["https://orcid.org/0000-0001-7153-6556"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210113950","display_name":"Alexandra Hospital","ror":"https://ror.org/029hept94","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210113950"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Flora Zagouri","raw_affiliation_strings":["Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210113950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090633646","display_name":"Helen J Gogas","orcid":"https://orcid.org/0000-0002-0451-2885","observed_orcids":["https://orcid.org/0000-0002-0451-2885"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Helen Gogas","raw_affiliation_strings":["First Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090216312","display_name":"Evangelia D. Razis","orcid":"https://orcid.org/0000-0003-3873-2947","observed_orcids":["https://orcid.org/0000-0003-3873-2947"]},"institutions":[{"id":"https://openalex.org/I4210122009","display_name":"Hygeia Hospital","ror":"https://ror.org/03qv5tx95","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210122009"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelia Razis","raw_affiliation_strings":["Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210122009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015437737","display_name":"George E. Pentheroudakis","orcid":"https://orcid.org/0000-0002-6632-2462","observed_orcids":["https://orcid.org/0000-0002-6632-2462"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Pentheroudakis","raw_affiliation_strings":["Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Thessalon\u00edki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Thessalon\u00edki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101789426","display_name":"Christos Christodoulou","orcid":"https://orcid.org/0000-0002-7959-0343","observed_orcids":["https://orcid.org/0000-0002-7959-0343"]},"institutions":[{"id":"https://openalex.org/I4210150697","display_name":"Metropolitan Hospital","ror":"https://ror.org/05a3efx98","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210150697"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Christodoulou","raw_affiliation_strings":["Second Department of Medical Oncology, Metropolitan Hospital, Piraeus, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medical Oncology, Metropolitan Hospital, Piraeus, Greece","institution_ids":["https://openalex.org/I4210150697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012112204","display_name":"Dimitrios G. Pectasides","orcid":"https://orcid.org/0000-0002-2102-2167","observed_orcids":["https://orcid.org/0000-0002-2102-2167"]},"institutions":[{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Pectasides","raw_affiliation_strings":["Oncology Section, Second Department of Internal Medicine, Hippokration Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Section, Second Department of Internal Medicine, Hippokration Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210165841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041575636","display_name":"George Fountzilas","orcid":"https://orcid.org/0000-0001-8045-2186","observed_orcids":["https://orcid.org/0000-0001-8045-2186"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Fountzilas","raw_affiliation_strings":["Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Thessalon\u00edki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki, Thessalon\u00edki, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5882,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.63724741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":"5","first_page":"2365","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9810000061988831},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/p-cadherin","display_name":"P-cadherin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8259999752044678},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.890999972820282},{"id":"https://openalex.org/keywords/keratin-5","display_name":"keratin 5","score":0.9419999718666077},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8389999866485596},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6766101121902466},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6313040256500244},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6122055053710938},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.6111170053482056},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5844317078590393},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.5634304881095886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5213662385940552},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5198565125465393},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.492903470993042},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4927370846271515},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46057629585266113},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44906678795814514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40170547366142273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3907017111778259},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3780737817287445},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24269312620162964},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13069725036621094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:27127145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27127145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2364062175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27127145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2536673672","https://openalex.org/W2040468936","https://openalex.org/W2359950124","https://openalex.org/W1963888992","https://openalex.org/W2208207805","https://openalex.org/W4403648485","https://openalex.org/W1966788277","https://openalex.org/W2118788727","https://openalex.org/W2026430211","https://openalex.org/W2377052951"],"abstract_inverted_index":{"Wnt":[0],"and":[1,9,59,89,101,184,211],"epidermal":[2],"growth":[3],"factor":[4],"receptor":[5],"(EGFR)":[6],"pathway":[7],"abnormalities":[8],"de-stabilization":[10],"of":[11,18,21,32,40,64,112,132,144,164,180,189],"cell":[12,136],"adhesion":[13],"are":[14],"all":[15],"important":[16],"aspects":[17],"the":[19,30,38,46,135,142,145,162],"pathogenesis":[20],"triple-negative":[22],"breast":[23],"cancer":[24],"(TNBC).":[25],"Herein":[26],"we":[27],"investigated":[28],"how":[29],"expression":[31,87,131,140,166],"related":[33],"protein":[34,86],"markers":[35,115],"may":[36,191],"affect":[37,118],"outcome":[39,194],"patients":[41],"bearing":[42],"TNBC":[43,181],"treated":[44],"in":[45,70,110,134,161,195],"adjuvant":[47],"setting.":[48],"Immunohistochemistry":[49],"for":[50,174,204],"beta-catenin,":[51],"Myc":[52],"(Wnt":[53],"pathway),":[54],"E-cadherin,":[55],"P-cadherin":[56,102],"(cell-adhesion),":[57],"EGFR":[58,165],"cytokeratin":[60],"5":[61],"(CK5)":[62],"(identification":[63],"basal-like":[65,98],"tumors)":[66],"was":[67,77,126,148],"carried":[68],"out":[69],"364":[71],"centrally":[72],"confirmed":[73],"TNBCs.":[74],"Survival":[75],"analysis":[76],"performed":[78],"with":[79,106,150,206],"Cox-regression":[80],"models":[81],"according":[82],"to":[83,208],"dichotomized":[84],"continuous":[85],"data":[88],"marker":[90],"interactions.":[91],"In":[92],"352":[93],"evaluable":[94],"tumors,":[95],"81.5%":[96],"were":[97,103],"TNBC.":[99],"E-cadherin":[100,183],"positively":[104],"associated,":[105],"co-expression":[107],"being":[108],"present":[109],"68%":[111],"tumors.":[113],"Individual":[114],"did":[116],"not":[117,160],"patient":[119,193],"outcome.":[120],"However,":[121],"a":[122],"statistically":[123],"significant":[124],"interaction":[125,170,201],"shown":[127],"such":[128],"that":[129,156],"low":[130],"beta-catenin":[133,190],"membrane,":[137],"defined":[138],"as":[139],"below":[141],"median":[143],"H-score":[146],"distribution,":[147],"associated":[149],"unfavourable":[151],"disease-free":[152],"survival":[153],"among":[154],"tumors":[155],"expressed":[157],"EGFR,":[158],"but":[159],"absence":[163],"(interaction":[167],"p=0.0085).":[168],"The":[169],"persisted":[171],"after":[172],"correcting":[173],"clinicopathological":[175],"variables.":[176],"A":[177],"considerable":[178],"number":[179],"co-expresses":[182],"P-cadherin,":[185],"while":[186],"membranous":[187],"localization":[188],"predict":[192],"an":[196],"EGFR-dependent":[197],"manner.":[198],"This":[199],"novel":[200],"seems":[202],"worthy":[203],"validating":[205],"regards":[207],"its":[209],"biological":[210],"clinical":[212],"relevance.":[213]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}