{"id":"https://openalex.org/W2363687504","doi":null,"title":"Effects of Fenofibrate on neonatal rat hypertrophic cardiomyocyte in vitro","display_name":"Effects of Fenofibrate on neonatal rat hypertrophic cardiomyocyte in vitro","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2363687504","mag":"2363687504"},"language":"en","primary_location":{"id":"mag:2363687504","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB200608007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056243315","display_name":"Yongyao Yang","orcid":"https://orcid.org/0000-0001-9206-4404","observed_orcids":["https://orcid.org/0000-0001-9206-4404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongyao Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9206-4404","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027123546","display_name":"LI Long-gui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LI Long-gui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010610","display_name":"Qiang Wu","orcid":"https://orcid.org/0000-0002-4368-8760","observed_orcids":["https://orcid.org/0000-0002-4368-8760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4368-8760","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028263710","display_name":"Qin Hu","orcid":"https://orcid.org/0000-0002-2270-8822","observed_orcids":["https://orcid.org/0000-0002-2270-8822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100967222","display_name":"Zhaohua Geng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaohua Geng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19211447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fenofibrate","display_name":"fenofibrate","score":1.0},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.984000027179718},{"id":"https://openalex.org/keywords/neonatal-rat-cardiomyocytes","display_name":"neonatal rat cardiomyocytes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cardiomyocyte-viability","display_name":"cardiomyocyte viability","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.775776207447052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6944010257720947},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6427947282791138},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6379910111427307},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.577124834060669},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5533372163772583},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5026922225952148},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.49055761098861694},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4881173074245453},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4514162540435791},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41810816526412964},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.41131383180618286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40859198570251465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3409695625305176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30585038661956787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.057465046644210815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2363687504","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB200608007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2352952570","https://openalex.org/W2371587952","https://openalex.org/W2366467018","https://openalex.org/W2099847590","https://openalex.org/W2381287440","https://openalex.org/W2081813895","https://openalex.org/W2376834543","https://openalex.org/W2390924094","https://openalex.org/W2381236280","https://openalex.org/W2884130295"],"abstract_inverted_index":{"Objective:To":[0],"study":[1],"the":[2,13,37,66,88,93,134],"inhibitory":[3],"effects":[4],"of":[5,24,26,39,46,53,90,136],"peroxisome":[6],"proliferator-activated":[7],"receptor":[8],"\u03b1":[9],"activator":[10],"Fenofibrate":[11,121],"on":[12,92,114],"angiotensin":[14],"\u2161(Ang":[15],"\u2161)-induced":[16],"cardiac":[17,29,47,86,94,118,137],"hypertrophy":[18,25],"in":[19,105,133],"vitro.":[20],"Methods:":[21],"A":[22],"model":[23],"neonatal":[27],"rat":[28],"myocytes":[30,48,119],"was":[31,59,70,123,131,141],"established":[32],"with":[33,125],"Ang":[34,81,84,115,126],"\u2161":[35,116],"stimulation.With":[36],"aid":[38],"Leca":[40],"Qwin":[41],"Image":[42],"software,the":[43],"surface":[44],"areas":[45],"were":[49],"analyzed.The":[50],"mRNA":[51,101,104],"expression":[52,99],"\u03b1\u3001\u03b2-myosin":[54],"heavy":[55],"chains(\u03b1-MHC\u3001\u03b2-MHC)":[56],"and":[57,97,102],"PPAR\u03b1":[58,103],"measured":[60],"by":[61,72],"reverse":[62],"transcription-polymerase":[63],"chain":[64],"reaction(RT-PCR),and":[65],"cultured":[67],"myocyte":[68,95],"viability":[69,96],"estimated":[71],"MTT":[73],"assay.":[74],"Results:Fenofibrate":[75],"pretreatment":[76],"24":[77],"h":[78],"prior":[79],"to":[80],"\u2161Significantly":[82],"reduced":[83],"\u2161-induced":[85],"hypertrophy,inhibited":[87],"effect":[89,113],"Ang\u2161":[91],"increased":[98],"of\u03b1/\u03b2-MHC":[100],"a":[106],"dose-dependent":[107],"manner.In":[108],"contrast,Fenofibrate":[109],"had":[110],"no":[111],"significant":[112],"treated":[117],"when":[120],"treatment":[122,140],"concomitant":[124],"\u2161.":[127],"Conclusion:":[128],"PPAR\u03b1-dependent":[129],"pathway":[130],"involved":[132],"inhibition":[135],"hypertrophy,but":[138],"chronic":[139],"needed.":[142]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
